Patents by Inventor Abdi R. Khokhar

Abdi R. Khokhar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diamine platinum complexes as antitumor agents
    Patent number: 5393909
    Abstract: Novel 1,4-diaminocyclohexane platinum II and platinum IV complexes were synthesized which show activity in vivo against tumor models resistant to cis-platin and tetraplatin. The novel complexes include the sulfato, chloro, hydroxyl, acetato methylmalonato, tartronato and 1,1-cyclobutane dicarboxylato as leaving ligands and 1,4-DACH amine as non-leaving ligands. The complexes showed good in vitro cytotoxic activity against murine leukemia L1210/0 and human ovarian A2780 cell lines. High in vivo activity was shown against L1210 leukemia cells and against cis-platin resistant L1210/DDP and tetraplatin resistant L1210/DACH. Excellent antitumor activity against M5076 was also exhibited by the new complexes. Additionally, the platinum complexes did not elicit any indication of nephrotoxicity in the in vivo tests.
    Type: Grant
    Filed: February 23, 1994
    Date of Patent: February 28, 1995
    Assignee: Board of Regents, The University of Texas System
    Inventors: Abdi R. Khokhar, Zahid H. Siddik