Patents by Inventor Abdou Rachid Thiam

Abdou Rachid Thiam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for analyzing the ability of a substance to cross a bilayer membrane
    Patent number: 10816560
    Abstract: The present invention relates to a method to analyse the ability of a substance (3) to cross a bilayer membrane comprising the following steps: (i) providing in a hydrophobic medium (1) a first droplet D1 of an aqueous solution AS1, wherein the droplet D1 is surrounded by a monolayer of amphiphilic molecules (2), (ii) providing in the said hydrophobic medium (1) a second droplet D2 of an aqueous solution AS2 containing the substance (3) to be analysed, wherein the droplet D2 is surrounded by a monolayer of amphiphilic molecules (2), (iii) putting the first droplet D1 and the second droplet D2 into contact so as to form a bilayer of amphiphilic molecules (2) in the contact area and to have a contact angle 2? between the two droplets D1 and D2 comprised between 10° and 180°, (iv) adding to the hydrophobic medium (1) a solvent capable of separating the droplets D1 and D2 put into contact, (v) collecting the droplet D1, and (vi) analysing the content of the droplet D1 in order to determine the presence or not of
    Type: Grant
    Filed: July 4, 2017
    Date of Patent: October 27, 2020
    Assignees: Paris Sciences Et Lettres—Quartier Latia, Universite Paris Diderot Paris 7, Centre National de la Recherche Scientifique (CNRS), Sorbonne Universite
    Inventor: Abdou Rachid Thiam
  • Method for analyzing the activity of an ion channel
    Patent number: 10690680
    Abstract: A method to analyze the activity of an ion channel comprising: providing in a hydrophobic medium a first droplet of an aqueous solution AS1 comprising a concentration q of an ion I with c1?0, wherein the droplet is surrounded by a monolayer of amphiphilic molecules; providing in the hydrophobic medium a second droplet of an aqueous solution AS2 comprising a concentration c2 of the ion I with c2?0, and c2?c1, wherein the second droplet is surrounded by a monolayer of amphiphilic molecules further comprising the ion channels to an analyzed; bringing the first droplet and the second droplet into contact so as to form a bilayer of amphiphilic molecules, wherein the bilayer further comprises ion channels to be analyzed, and measuring the radius of the two droplets when they are brought into contact referred to as initial state; and maintaining the first droplet and the second droplet in contact until equilibrium is reached and measuring the radius of the two contacted droplets or determining the number of resultin
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: June 23, 2020
    Assignees: Paris Sciences Et Lettres - Quartier Latin, Universite Paris Diderot Paris 7, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
    Inventors: Abdou Rachid Thiam, Béatrice Schaack
  • METHOD FOR ANALYZING THE ABILITY OF A SUBSTANCE TO CROSS A BILAYER MEMBRANE
    Publication number: 20190242914
    Abstract: The present invention relates to a method to analyse the ability of a substance (3) to cross a bilayer membrane comprising the following steps: (i) providing in a hydrophobic medium (1) a first droplet D1 of an aqueous solution AS1, wherein the droplet D1 is surrounded by a monolayer of amphiphilic molecules (2), (ii) providing in the said hydrophobic medium (1) a second droplet D2 of an aqueous solution AS2 containing the substance (3) to be analysed, wherein the droplet D2 is surrounded by a monolayer of amphiphilic molecules (2), (iii) putting the first droplet D1 and the second droplet D2 into contact so as to form a bilayer of amphiphilic molecules (2) in the contact area and to have a contact angle 2? between the two droplets D1 and D2 comprised between 10° and 180°, (iv) adding to the hydrophobic medium (1) a solvent capable of separating the droplets D1 and D2 put into contact, (v) collecting the droplet D1, and (vi) analysing the content of the droplet D1 in order to determine the presence or not of
    Type: Application
    Filed: July 4, 2017
    Publication date: August 8, 2019
    Applicants: Paris Sciences Et Lettres - Quartier Latin, Universite Paris Diderot Paris 7, Centre National de la Recherche Scientifique (CNRS), Sorbonne Universite
    Inventor: Abdou Rachid Thiam
  • A METHOD FOR ANALYZING THE ACTIVITY OF AN ION CHANNEL
    Publication number: 20180356430
    Abstract: A method to analyze the activity of an ion channel comprising: providing in a hydrophobic medium a first droplet of an aqueous solution AS1 comprising a concentration q of an ion I with c1?0, wherein the droplet is surrounded by a monolayer of amphiphilic molecules; providing in the hydrophobic medium a second droplet of an aqueous solution AS2 comprising a concentration c2 of the ion I with c2?0, and c2?c1, wherein the second droplet is surrounded by a monolayer of amphiphilic molecules further comprising the ion channels to an analyzed; bringing the first droplet and the second droplet into contact so as to form a bilayer of amphiphilic molecules, wherein the bilayer further comprises ion channels to be analyzed, and measuring the radius of the two droplets when they are brought into contact referred to as initial state; and maintaining the first droplet and the second droplet in contact until equilibrium is reached and measuring the radius of the two contacted droplets or determining the number of resultin
    Type: Application
    Filed: November 17, 2016
    Publication date: December 13, 2018
    Applicants: Paris Sciences Et Lettres - Quartier Latin, Universite Paris Diderot Paris 7, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
    Inventors: Abdou Rachid Thiam, Béatrice Schaack