Abstract: A biofiltration system for treating biodegradable airborne contaminants such as VOCS includes a bio-reactor chamber with a sealed housing, and a heater for maintaining a temperature within the chamber. Several fabric-based bio-reactor panels are mounted within the chamber and are kept in a dampened state by means of an applicator system which applies a temperature-controlled liquid mixture containing microbes and nutrients to the bio-reactor panels. An air handling system moves air laden with biodegradable contaminants through the chamber and over the surfaces of the bio-reactor panels.