Abstract: This application discloses a server to transmit an embedded application to a remote gateway device. The embedded application, when executed, prompts the remote gateway device to generate application messages including information associated with the execution of the embedded application by the remote gateway device. The server is configured to track the execution of the embedded application in the remote gateway device to determine operational states of the embedded application based, at least in part, on the application messages received from the remote gateway device. The server is configured to generate a parameter message for transmission to the remote gateway device based, at least in part, on the operational states of the embedded application deployed in the remote gateway device. The parameter message is configured to prompt the remote gateway device to transmit an application parameter associated with the execution of the embedded application.

Abstract: Methods of LC-MS/MS quantification of ?-carboxylated proteins in plasma, serum, or blood, including dried blood spots, are disclosed. The methods can be used to determine patient-specific dosing of anticoagulant drugs and diagnosis of liver diseases, such as hepatocellular carcinoma.

Abstract: Techniques are provided for block allocation for persistent memory during aggregate transition. In a high availability pair including first and second nodes, the first node makes a determination that control of a first aggregate is to transition from the first node to the second node. A portion of available free storage space is allocated from a first persistent memory of the first node as allocated pages within the first persistent memory. Metadata information for the allocated pages is updated with an identifier of the first aggregate to create updated metadata information reserving the allocated pages for the first aggregate. The updated metadata information is mirrored to the second node, so that the second node also reserves those pages. Control of the first aggregate is transitioned to the second node. As a result, the nodes do not attempt allocating the same free pages to different aggregates during a transition.

Abstract: Techniques are provided for implementing write ordering for persistent memory. A set of actions are identified for commitment to persistent memory of a node for executing an operation upon the persistent memory. An episode is created to comprise a first subset of actions of the set of actions that can be committed to the persistent memory in any order with respect to one another such that a consistent state of the persistent memory can be reconstructed in the event of a crash of the node during execution of the operation. The first subset of actions within the episode are committed to the persistent memory and further execution of the operation is blocked until the episode completes.

Abstract: The invention includes methods of preventing or treating acute lung injury using a MAP3K2/MAP3K3 inhibitor. The invention further comprises compositions, and kits comprising compositions useful within the invention.

Abstract: Techniques are provided for implementing a file system format for persistent memory. A node, comprising persistent memory, receives an operation comprising a file identifier and file system instance information. A list of file system info objects are evaluated to identify a file system info object matching the file system instance information. An inofile, identified by the file system info object as being associated with inodes of files within an instance of the file system targeted by the operation, is traversed to identify an inode matching the file identifier. If the inode comprises an indicator that the file is tiered into the persistent memory, then the inode it utilized to facilitate execution of the operation upon the persistent memory. Otherwise, the operation is routed to a storage file system tier for execution by a storage file system upon storage associated with the node.

Abstract: Techniques are provided for implementing write ordering for persistent memory. A set of actions are identified for commitment to persistent memory of a node for executing an operation upon the persistent memory. An episode is created to comprise a first subset of actions of the set of actions that can be committed to the persistent memory in any order with respect to one another such that a consistent state of the persistent memory can be reconstructed in the event of a crash of the node during execution of the operation. The first subset of actions within the episode are committed to the persistent memory and further execution of the operation is blocked until the episode completes.

Abstract: Treatment of testosterone deficiency in men by a precision medicine approach using a biomarker of activity of UGT2B17 that is involved in testosterone urinary elimination. By inhibiting UGT2B17, alone or in combination with administration of testosterone, testosterone deficiency in men can be treatable. Further, a method of dose selection for precise dosing of UGT2B17 substrate drugs is provided. Additionally, methods for safe dosing of pharmaceutical agents that undergo UGT2B17-mediated acyl glucuronidation are provided.

Abstract: Techniques are provided for implementing a file system format for persistent memory. A node, with persistent memory, receives an operation associated with a file identifier and file system instance information. A list of file system info objects are evaluated to identify a file system info object matching the file system instance information. An inofile, identified by the file system info object as being associated with inodes of files within an instance of the file system targeted by the operation, is traversed to identify an inode matching the file identifier. If the inode has an indicator that the file is tiered into the persistent memory, then the inode it utilized to facilitate execution of the operation upon the persistent memory. Otherwise, the operation is routed to a storage file system tier for execution by a storage file system upon storage associated with the node.

Abstract: The invention includes methods of preventing or treating acute lung injury using a MAP3K2/MAP3K3 inhibitor. The invention further comprises compositions, and kits comprising compositions useful within the invention.

Abstract: Methods, non-transitory computer readable media, and computing devices that execute a storage operation, without journaling the storage operation in a log, and withhold from a file system a list of freed inodes including an indication of an inode freed as a result of the execution of the storage operation. A consistency point operation is then initiated that retrieves storage operations logged as journal entries in the log and commits a result of each of the storage operations to data storage devices. A list of available inodes is updated based on the list of freed inodes, when the consistency point operation is determined to be complete. This technology reduces the number of storage operations that are required to be journaled to maintain consistency of a file system, thereby reducing the runtime resources required to facilitate the journaling and replay resource required to replay the storage operations following a recovery.

Abstract: A delayed release drug formulation includes a core and a coating. The coating includes a mixture of a first material selected from starch; amylose; amylopectin; chitosan; chondroitin sulfate; cyclodextrin; dextran; pullulan; carrageenan; scleroglucan; chitin; curdulan and levan, and a second material which has a pH threshold at about pH 5 or above. The delayed release drug formulation is used to target release of a drug from a core to the intestine, particularly the colon.

Abstract: A delayed release coating includes a mixture of a first material selected from starch; amylose; amylopectin; chitosan; chondroitin sulfate; cyclodextrin; dextran; pullulan; carrageenan; scleroglucan; chitin; curdulan and levan, and a second material which has a pH threshold at about pH 5 or above. The delayed release coating is used to target release of a drug from a core to the intestine, particularly the colon.

Abstract: A delayed release drug formulation includes a core and a coating. The coating includes a mixture of a first material selected from starch; amylose; amylopectin; chitosan; chondroitin sulfate; cyclodextrin; dextran; pullulan; carrageenan; scleroglucan; chitin; curdulan and levan, and a second material which has a pH threshold at about pH 5 or above. The delayed release drug formulation is used to target release of a drug from a core to the intestine, particularly the colon.

Abstract: A delayed release coating includes a mixture of a first material selected from starch; amylose; amylopectin; chitosan; chondroitin sulfate; cyclodextrin; dextran; pullulan; carrageenan; scleroglucan; chitin; curdulan and levan, and a second material which has a pH threshold at about pH 5 or above. The delayed release coating is used to target release of a drug from a core to the intestine, particularly the colon.

Abstract: A system for controlling building services, the system including a services array supporting a plurality of service devices, an electronic controller that communicates with a client device to determine a selected profile defining service device settings and control the service devices in the services array in accordance with the service device settings defined by the profile, to thereby at least partially control building services.

Abstract: Methods, non-transitory computer readable media, and computing devices that execute a storage operation, without journaling the storage operation in a log, and withhold from a file system a list of freed inodes including an indication of an inode freed as a result of the execution of the storage operation. A consistency point operation is then initiated that retrieves storage operations logged as journal entries in the log and commits a result of each of the storage operations to data storage devices. A list of available inodes is updated based on the list of freed inodes, when the consistency point operation is determined to be complete. This technology reduces the number of storage operations that are required to be journaled to maintain consistency of a file system, thereby reducing the runtime resources required to facilitate the journaling and replay resource required to replay the storage operations following a recovery.

Abstract: A method, non-transitory computer readable medium and storage server computing device that determines when a generated storage operation corresponds with one of a set of predefined storage operations. The storage operation is executed and a result of the execution of the storage operation is withheld from a file system, when the determining indicates that the storage operation corresponds with one of the set of predefined storage operations. A determination is made when a consistency point operation has completed. The result of the execution of the storage operation is presented to the file system, when the determining indicates that a consistency point operation has completed. This technology reduces the number of storage operations that are required to be journaled to maintain consistency of a file system, thereby reducing the runtime resources required to facilitate the journaling and replay resource required to replay the storage operations in a journal following a recovery.

Abstract: A process for producing a solid pharmaceutical dosage formulation, said process comprising powder bed fusion selective laser 3-dimensional printing of a mixture comprising: (a)a drug; and (b)an excipient; whereinat least one of said drug and said excipient absorbs electromagnetic radiation at a wavelength emitted by the laser; or (a)a drug; (b)an excipient; and (c)an absorbent material which absorbs electromagnetic radiation at a wavelength emitted by the laser.

Abstract: Treatment of testosterone deficiency in men by a precision medicine approach using a biomarker of activity of UGT2B17 that is involved in testosterone urinary elimination. By inhibiting UGT2B17, alone or in combination with administration of testosterone, testosterone deficiency in men can be treatable. Further, a method of dose selection for precise dosing of UGT2B17 substrate drugs is provided. Additionally, methods for safe dosing of pharmaceutical agents that undergo UGT2B17-mediated acyl glucuronidation are provided.