Abstract: The present disclosure describes a method and system for processing and indexing data from a continuously updated distributed database. The method and system employ a portioned database architecture to return results in a constant-time query and reduce the storage size of indexed records. The database partitions include a plurality of data records correspond to an index group in a single row of a rowKey table. The index group comprises data records that are indexed in a predetermined indexing interval. The portioned database architecture allows record fields to be queried from the index group.

Abstract: The presently disclosed subject matter provides antibodies or antigen-binding fragments thereof that bind to DLL3 and methods of using such antibodies or antigen-binding fragments thereof same.

Abstract: The presently disclosed subject matter provides antibodies or antigen-binding fragments thereof that bind to CD33 and methods of using such antibodies or antigen-binding fragments thereof same.

Abstract: An igniter for a combustor of a turbomachine includes a fuel inlet in fluid communication with a mixing plenum. The mixing plenum is positioned upstream of a mixing channel. An air inlet is in fluid communication with the mixing plenum and an ignition source is in operative communication with the mixing channel. The igniter may include a mounting flange configured for coupling the igniter to the combustor. The ignition source may be positioned proximate to a downstream end of the mixing channel and upstream of the mounting flange. The mixing channel may define a venturi shape. The venturi shape includes a converging section between an upstream end of the mixing channel and a venturi throat.

Abstract: The presently disclosed subject matter provides compositions and methods for in vivo diagnosis and treatment of diseases or disorders associated with DLL3. In particular, the presently disclosed subject matter provides novel anti-DLL3 antibodies-TCO conjugates, which can form a radioimmunoconjugate with a radioligand comprising a radioactive isotope.

Abstract: The presently disclosed subject matter provides for antigen-recognizing receptors that specifically target CD33 and cells comprising such CD33-targeted antigen-recognizing receptors. The presently disclosed subject matter further provides uses of the CD33-targeted antigen-recognizing receptors for treatment.

Abstract: The present invention provides a novel anti-DLL3 antibody-pyrrolodiazepine derivative and a novel anti-DLL3 anti-body-pyrrolodiazepine derivative conjugate using the same.

Abstract: It is an object of the present invention to provide an antibody-drug conjugate of an antibody binding to DLL3 and a drug having antitumor activity, a pharmaceutical composition comprising the antibody-drug conjugate and having therapeutic effects on a tumor, a method for treating a tumor using the antibody-drug conjugate or the pharmaceutical composition, and the like. The present invention provides an antibody-drug conjugate of an antibody binding to DLL3 and a drug having antitumor activity, a pharmaceutical composition comprising the antibody or the antibody-drug conjugate, and a method for treating a tumor.

Abstract: The present disclosure relates to antibody-based molecules, including antibodies, epitope-binding domains thereof, and antibody derivative as described herein, that are capable of binding and inhibiting cell migration-inducing and hyaluronan-binding protein (CEMIP). Such antibody-based molecules are useful for the treatment of conditions where a subject is in need of blocking the activity of CEMIP.

Abstract: An igniter for a combustor of a turbomachine includes a fuel inlet in fluid communication with a mixing plenum. The mixing plenum is positioned upstream of a mixing channel. An air inlet is in fluid communication with the mixing plenum and an ignition source is in operative communication with the mixing channel. The igniter may include a mounting flange configured for coupling the igniter to the combustor. The ignition source may be positioned proximate to a downstream end of the mixing channel and upstream of the mounting flange. The mixing channel may define a venturi shape. The venturi shape includes a converging section between an upstream end of the mixing channel and a venturi throat.

Abstract: A high availability aircraft network architecture incorporating smart points of presence (SPoP) is disclosed. In embodiments, the network architecture divides the aircraft into districts, or physical subdivisions. Each district includes one or more mission systems (MS) smart network access point (SNAP) devices for connecting MS components and devices located within its district to the MS network. Similarly, each district includes one or more air vehicle systems (AVS) SNAP devices for connecting AVS components and devices within the district to the AVS network. The AVS network may remain in a star or hub-and-spoke topology, while the MS network may be configured in a ring or mesh topology. Selected MS and AVS SNAP devices may be connected to each other via guarded network bridges to securely interconnect the MS and AVS networks.

Abstract: An igniter for a combustor of a turbomachine includes a fuel inlet in fluid communication with a mixing plenum. The mixing plenum is positioned upstream of a mixing channel. An air inlet is in fluid communication with the mixing plenum and an ignition source is in operative communication with the mixing channel. The igniter may include a mounting flange configured for coupling the igniter to the combustor. The ignition source may be positioned proximate to a downstream end of the mixing channel and upstream of the mounting flange. The mixing channel may define a venturi shape. The venturi shape includes a converging section between an upstream end of the mixing channel and a venturi throat.

Abstract: The present disclosure relates generally to immunoglobulin-related compositions (e.g., antibodies or antigen binding fragments thereof) that can bind to delta-like protein 3 (DLL3). The antibodies of the present technology are useful in methods for detecting and treating a DLL3-associated cancer in a subject in need thereof.

Abstract: A smart network access point (SNAP) device is disclosed. In embodiments, the SNAP device includes trunk ports for accepting a network trunk cable (e.g., fiber optic trunk) and thereby connecting the SNAP device to an aircraft-based network of SNAP devices. The SNAP device includes switch ports for incorporating physical connections to mission systems (MS) or air vehicle systems (AVS) components and devices, providing a local smart point of presence (SPoP) throughout a physical subdivision (e.g., network district) of an aircraft. The SNAP device is configured for monitoring data exchanges between local MS/AVS components and the aircraft network. The SNAP device includes a cybersecurity module for connecting to local security components (e.g., data guards and multiple levels of security (MLS) encryption/decryption) or for providing built-in data guard and encryption/decryption services. The SNAP device includes power control components for managing power distribution to the connected local network components.

Abstract: A smart network access point (SNAP) device is disclosed. In embodiments, the SNAP device includes trunk ports for accepting a network trunk cable (e.g., fiber optic trunk) and thereby connecting the SNAP device to an aircraft-based network of SNAP devices. The SNAP device includes switch ports for incorporating physical connections to mission systems (MS) or air vehicle systems (AVS) components and devices, providing a local smart point of presence (SPoP) throughout a physical subdivision (e.g., network district) of an aircraft. The SNAP device is configured for monitoring data exchanges between local MS/AVS components and the aircraft network. The SNAP device includes a cybersecurity module for connecting to local security components (e.g., data guards and multiple levels of security (MLS) encryption/decryption) or for providing built-in data guard and encryption/decryption services. The SNAP device includes power control components for managing power distribution to the connected local network components.

Abstract: A high availability aircraft network architecture incorporating smart points of presence (SPoP) is disclosed. In embodiments, the network architecture divides the aircraft into districts, or physical subdivisions. Each district includes one or more mission systems (MS) smart network access point (SNAP) devices for connecting MS components and devices located within its district to the MS network. Similarly, each district includes one or more air vehicle systems (AVS) SNAP devices for connecting AVS components and devices within the district to the AVS network. The AVS network may remain in a star or hub-and-spoke topology, while the MS network may be configured in a ring or mesh topology. Selected MS and AVS SNAP devices may be connected to each other via guarded network bridges to securely interconnect the MS and AVS networks.

Abstract: A string light storage container. The string light storage container includes a base. The base defines a cylinder rising upward therefrom. The cylinder is centrally disposed in the base. The cylinder is shaped to receive string lights therearound. A cover is removably securable to the base via a fastener, such that an interior cavity is formed around the cylinder when the cover is engaged with the base.

Abstract: An igniter for a combustor of a turbomachine includes a fuel inlet in fluid communication with a mixing plenum. The mixing plenum is positioned upstream of a mixing channel. An air inlet is in fluid communication with the mixing plenum and an ignition source is in operative communication with the mixing channel. The igniter may include a mounting flange configured for coupling the igniter to the combustor. The ignition source may be positioned proximate to a downstream end of the mixing channel and upstream of the mounting flange. The mixing channel may define a venturi shape. The venturi shape includes a converging section between an upstream end of the mixing channel and a venturi throat.

Abstract: A combustion system includes a first combustion chamber and a second combustion chamber. The second combustion chamber is positioned downstream of the first combustion chamber. The combustion system also includes a pre-mixed, direct-injection secondary fuel nozzle. The pre-mixed, direct-injection secondary fuel nozzle extends through the first combustion chamber into the second combustion chamber.