Abstract: The presently disclosed subject matter provides for antigen-recognizing receptors that specifically target L1CAM and cells comprising such L1CAM-targeted antigen-recognizing receptors. The presently disclosed subject matter further provides uses of the L1CAM-targeted antigen-recognizing receptors for treatment.

Abstract: A method implements contextual visualization of trustworthiness for subsurface data. The method involves displaying a version train view for a hierarchical collection of a set of subsurface data. The version train view includes a version train element of a first version of the hierarchical collection. The version train element displays stamp data. The method further involves displaying a comparison view with a first version view of the first version and a second version view of a second version of the hierarchical collection. The method further involves comparing the first version to the second version to generate difference data. The method further involves updating the first version view and the second version view with the difference data to form an updated first version view and an updated second version view. The method further involves displaying the updated first version view and the updated second version view.

Abstract: The presently disclosed subject matter provides antibodies or antigen-binding fragments thereof that bind to L1CAM and methods of using such antibodies or antigen-binding fragments thereof. The presently disclosed subject further provides immunoconjugates comprising anti-L1CAM antibodies or antigen-binding fragments thereof and methods of using such immunoconjugates.

Abstract: The present disclosure relates generally to immunoglobulin-related compositions (e.g., antibodies or antigen binding fragments thereof) that can bind to delta-like protein 3 (DLL3). The antibodies of the present technology are useful in methods for detecting and treating a DLL3-associated cancer in a subject in need thereof.

Abstract: A method for identifying cyber assets and implementing cyber risk mitigation actions based on a democratic matching algorithm is disclosed. In one aspect, the method includes executing a plurality of cyber asset identification algorithms to identify a plurality of candidate match pairs, wherein each candidate match pair comprises two cyber assets identified as potential assets of the same entity by at least one of the cyber asset identification algorithms. The method can further include determining a true match probability for each candidate match pair, wherein the true match probability is the probability that the two cyber assets in the candidate match pair are assets of the same entity, and wherein the true match probability is based on which of the cyber asset identification algorithms identified the candidate match pair.

Abstract: The present disclosure describes a method and system for processing and indexing data from a continuously updated distributed database. The method and system employ a portioned database architecture to return results in a constant-time query and reduce the storage size of indexed records. The database partitions include a plurality of data records correspond to an index group in a single row of a rowKey table. The index group comprises data records that are indexed in a predetermined indexing interval. The portioned database architecture allows record fields to be queried from the index group.

Abstract: The present disclosure describes a method and system for processing and indexing data from a continuously updated distributed database. The method and system employ a portioned database architecture to return results in a constant-time query and reduce the storage size of indexed records. The database partitions include a plurality of data records correspond to an index group in a single row of a rowKey table. The index group comprises data records that are indexed in a predetermined indexing interval. The portioned database architecture allows record fields to be queried from the index group.

Abstract: The presently disclosed subject matter provides antibodies or antigen-binding fragments thereof that bind to DLL3 and methods of using such antibodies or antigen-binding fragments thereof same.

Abstract: The presently disclosed subject matter provides antibodies or antigen-binding fragments thereof that bind to CD33 and methods of using such antibodies or antigen-binding fragments thereof same.

Abstract: An igniter for a combustor of a turbomachine includes a fuel inlet in fluid communication with a mixing plenum. The mixing plenum is positioned upstream of a mixing channel. An air inlet is in fluid communication with the mixing plenum and an ignition source is in operative communication with the mixing channel. The igniter may include a mounting flange configured for coupling the igniter to the combustor. The ignition source may be positioned proximate to a downstream end of the mixing channel and upstream of the mounting flange. The mixing channel may define a venturi shape. The venturi shape includes a converging section between an upstream end of the mixing channel and a venturi throat.

Abstract: The presently disclosed subject matter provides compositions and methods for in vivo diagnosis and treatment of diseases or disorders associated with DLL3. In particular, the presently disclosed subject matter provides novel anti-DLL3 antibodies-TCO conjugates, which can form a radioimmunoconjugate with a radioligand comprising a radioactive isotope.

Abstract: The presently disclosed subject matter provides for antigen-recognizing receptors that specifically target CD33 and cells comprising such CD33-targeted antigen-recognizing receptors. The presently disclosed subject matter further provides uses of the CD33-targeted antigen-recognizing receptors for treatment.

Abstract: The present invention provides a novel anti-DLL3 antibody-pyrrolodiazepine derivative and a novel anti-DLL3 anti-body-pyrrolodiazepine derivative conjugate using the same.

Abstract: It is an object of the present invention to provide an antibody-drug conjugate of an antibody binding to DLL3 and a drug having antitumor activity, a pharmaceutical composition comprising the antibody-drug conjugate and having therapeutic effects on a tumor, a method for treating a tumor using the antibody-drug conjugate or the pharmaceutical composition, and the like. The present invention provides an antibody-drug conjugate of an antibody binding to DLL3 and a drug having antitumor activity, a pharmaceutical composition comprising the antibody or the antibody-drug conjugate, and a method for treating a tumor.

Abstract: The present disclosure relates to antibody-based molecules, including antibodies, epitope-binding domains thereof, and antibody derivative as described herein, that are capable of binding and inhibiting cell migration-inducing and hyaluronan-binding protein (CEMIP). Such antibody-based molecules are useful for the treatment of conditions where a subject is in need of blocking the activity of CEMIP.

Abstract: An igniter for a combustor of a turbomachine includes a fuel inlet in fluid communication with a mixing plenum. The mixing plenum is positioned upstream of a mixing channel. An air inlet is in fluid communication with the mixing plenum and an ignition source is in operative communication with the mixing channel. The igniter may include a mounting flange configured for coupling the igniter to the combustor. The ignition source may be positioned proximate to a downstream end of the mixing channel and upstream of the mounting flange. The mixing channel may define a venturi shape. The venturi shape includes a converging section between an upstream end of the mixing channel and a venturi throat.

Abstract: An igniter for a combustor of a turbomachine includes a fuel inlet in fluid communication with a mixing plenum. The mixing plenum is positioned upstream of a mixing channel. An air inlet is in fluid communication with the mixing plenum and an ignition source is in operative communication with the mixing channel. The igniter may include a mounting flange configured for coupling the igniter to the combustor. The ignition source may be positioned proximate to a downstream end of the mixing channel and upstream of the mounting flange. The mixing channel may define a venturi shape. The venturi shape includes a converging section between an upstream end of the mixing channel and a venturi throat.

Abstract: The present disclosure relates generally to immunoglobulin-related compositions (e.g., antibodies or antigen binding fragments thereof) that can bind to delta-like protein 3 (DLL3). The antibodies of the present technology are useful in methods for detecting and treating a DLL3-associated cancer in a subject in need thereof.

Abstract: A string light storage container. The string light storage container includes a base. The base defines a cylinder rising upward therefrom. The cylinder is centrally disposed in the base. The cylinder is shaped to receive string lights therearound. A cover is removably securable to the base via a fastener, such that an interior cavity is formed around the cylinder when the cover is engaged with the base.