Patents by Inventor Abdul Khan
Abdul Khan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12044180Abstract: An igniter for a combustor of a turbomachine includes a fuel inlet in fluid communication with a mixing plenum. The mixing plenum is positioned upstream of a mixing channel. An air inlet is in fluid communication with the mixing plenum and an ignition source is in operative communication with the mixing channel. The igniter may include a mounting flange configured for coupling the igniter to the combustor. The ignition source may be positioned proximate to a downstream end of the mixing channel and upstream of the mounting flange. The mixing channel may define a venturi shape. The venturi shape includes a converging section between an upstream end of the mixing channel and a venturi throat.Type: GrantFiled: October 27, 2022Date of Patent: July 23, 2024Assignee: GE Infrastructure Technology LLCInventors: Lucas John Stoia, Yimin Huang, Abdul Khan, Thomas Edward Johnson, Heath M. Ostebee, Jayaprakash Natarajan
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RADIOLIGAND BINDING TO ANTI-DLL3 ANTIBODIES FOR PRETARGETED PET IMAGING AND THERAPEUTIC USES THEREOF
Publication number: 20240216557Abstract: The presently disclosed subject matter provides compositions and methods for in vivo diagnosis and treatment of diseases or disorders associated with DLL3. In particular, the presently disclosed subject matter provides novel anti-DLL3 antibodies-TCO conjugates, which can form a radioimmunoconjugate with a radioligand comprising a radioactive isotope.Type: ApplicationFiled: February 28, 2024Publication date: July 4, 2024Applicants: Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute for Cancer Research, Memorial Hospital for Cancer and Allied Diseases, Tri-Institutional Therapeutics Discovery Institute, Inc.Inventors: John T. POIRIER, Charles Rudin, Jason Lewis, Abdul Khan, David Andrew, Xinlei Chen, Ivo C. Lorenz, Kathryn M. Tully, Salomon Tendler -
Publication number: 20240197879Abstract: The presently disclosed subject matter provides for antigen-recognizing receptors that specifically target CD33 and cells comprising such CD33-targeted antigen-recognizing receptors. The presently disclosed subject matter further provides uses of the CD33-targeted antigen-recognizing receptors for treatment.Type: ApplicationFiled: February 29, 2024Publication date: June 20, 2024Applicants: MEMORIAL SLOAN-KETTERING CANCER CENTER, SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH, MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES, TRI-INSTITUTIONAL THERAPEUTICS DISCOVERY INSTITUTE, INC.Inventors: Anthony Daniyan, Renier J. BRENTJENS, Ivo C. LORENZ, Abdul KHAN
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Publication number: 20240115721Abstract: It is an object of the present invention to provide an antibody-drug conjugate of an antibody binding to DLL3 and a drug having antitumor activity, a pharmaceutical composition comprising the antibody-drug conjugate and having therapeutic effects on a tumor, a method for treating a tumor using the antibody-drug conjugate or the pharmaceutical composition, and the like. The present invention provides an antibody-drug conjugate of an antibody binding to DLL3 and a drug having antitumor activity, a pharmaceutical composition comprising the antibody or the antibody-drug conjugate, and a method for treating a tumor.Type: ApplicationFiled: January 13, 2022Publication date: April 11, 2024Applicants: MEMORIAL SLOAN KETTERING CANCER CENTER, TRI-INSTITUTIONAL THERAPEUTICS DISCOVERY INSTITUTE, DAIICHI SANKYO COMPANY, LIMITEDInventors: John T. POIRIER, Charles RUDIN, Jason LEWIS, Abdul KHAN, David ANDREW, Xinlei CHEN, Ivo LORENZ, Hironori MATSUNAGA
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Publication number: 20240115720Abstract: The present invention provides a novel anti-DLL3 antibody-pyrrolodiazepine derivative and a novel anti-DLL3 anti-body-pyrrolodiazepine derivative conjugate using the same.Type: ApplicationFiled: January 13, 2022Publication date: April 11, 2024Applicants: MEMORIAL SLOAN KETTERING CANCER CENTER, TRI-INSTITUTIONAL THERAPEUTICS DISCOVERY INSTITUTE, DAIICHI SANKYO COMPANY, LIMITEDInventors: John T. POIRIER, Charles RUDIN, Jason LEWIS, Abdul KHAN, David ANDREW, Xinlei CHEN, Ivo LORENZ, Hironori MATSUNAGA
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Publication number: 20230391890Abstract: The present disclosure relates to antibody-based molecules, including antibodies, epitope-binding domains thereof, and antibody derivative as described herein, that are capable of binding and inhibiting cell migration-inducing and hyaluronan-binding protein (CEMIP). Such antibody-based molecules are useful for the treatment of conditions where a subject is in need of blocking the activity of CEMIP.Type: ApplicationFiled: October 15, 2021Publication date: December 7, 2023Inventors: David C. LYDEN, Goncalo RODRIGUES, Irena RAJNPREHT, Abdul KHAN, Ivo LORENZ, Irina MATEI
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Publication number: 20230045965Abstract: An igniter for a combustor of a turbomachine includes a fuel inlet in fluid communication with a mixing plenum. The mixing plenum is positioned upstream of a mixing channel. An air inlet is in fluid communication with the mixing plenum and an ignition source is in operative communication with the mixing channel. The igniter may include a mounting flange configured for coupling the igniter to the combustor. The ignition source may be positioned proximate to a downstream end of the mixing channel and upstream of the mounting flange. The mixing channel may define a venturi shape. The venturi shape includes a converging section between an upstream end of the mixing channel and a venturi throat.Type: ApplicationFiled: October 27, 2022Publication date: February 16, 2023Inventors: Lucas John Stoia, Yimin Huang, Abdul Khan, Thomas Edward Johnson, Heath M. Ostebee, Jayaprakash Natarajan
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Patent number: 11563642Abstract: A high availability aircraft network architecture incorporating smart points of presence (SPoP) is disclosed. In embodiments, the network architecture divides the aircraft into districts, or physical subdivisions. Each district includes one or more mission systems (MS) smart network access point (SNAP) devices for connecting MS components and devices located within its district to the MS network. Similarly, each district includes one or more air vehicle systems (AVS) SNAP devices for connecting AVS components and devices within the district to the AVS network. The AVS network may remain in a star or hub-and-spoke topology, while the MS network may be configured in a ring or mesh topology. Selected MS and AVS SNAP devices may be connected to each other via guarded network bridges to securely interconnect the MS and AVS networks.Type: GrantFiled: October 9, 2020Date of Patent: January 24, 2023Assignee: Rockwell Collins, Inc.Inventors: Patrick Gomez, Abdul A. Khan, Brian S. Rach, Charles Adams, Mitchell A. Riley, Max G. Taylor
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Patent number: 11519334Abstract: An igniter for a combustor of a turbomachine includes a fuel inlet in fluid communication with a mixing plenum. The mixing plenum is positioned upstream of a mixing channel. An air inlet is in fluid communication with the mixing plenum and an ignition source is in operative communication with the mixing channel. The igniter may include a mounting flange configured for coupling the igniter to the combustor. The ignition source may be positioned proximate to a downstream end of the mixing channel and upstream of the mounting flange. The mixing channel may define a venturi shape. The venturi shape includes a converging section between an upstream end of the mixing channel and a venturi throat.Type: GrantFiled: July 31, 2017Date of Patent: December 6, 2022Assignee: General Electric CompanyInventors: Lucas John Stoia, Yimin Huang, Abdul Khan, Thomas Edward Johnson, Heath M. Ostebee, Jayaprakash Natarajan
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Publication number: 20220348648Abstract: The present disclosure relates generally to immunoglobulin-related compositions (e.g., antibodies or antigen binding fragments thereof) that can bind to delta-like protein 3 (DLL3). The antibodies of the present technology are useful in methods for detecting and treating a DLL3-associated cancer in a subject in need thereof.Type: ApplicationFiled: July 8, 2020Publication date: November 3, 2022Inventors: John T. POIRIER, Charles RUDIN, Jason LEWIS, Abdul KHAN, David ANDREW, Xinlei CHEN, Ivo LORENZ
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Patent number: 11477088Abstract: A smart network access point (SNAP) device is disclosed. In embodiments, the SNAP device includes trunk ports for accepting a network trunk cable (e.g., fiber optic trunk) and thereby connecting the SNAP device to an aircraft-based network of SNAP devices. The SNAP device includes switch ports for incorporating physical connections to mission systems (MS) or air vehicle systems (AVS) components and devices, providing a local smart point of presence (SPoP) throughout a physical subdivision (e.g., network district) of an aircraft. The SNAP device is configured for monitoring data exchanges between local MS/AVS components and the aircraft network. The SNAP device includes a cybersecurity module for connecting to local security components (e.g., data guards and multiple levels of security (MLS) encryption/decryption) or for providing built-in data guard and encryption/decryption services. The SNAP device includes power control components for managing power distribution to the connected local network components.Type: GrantFiled: October 9, 2020Date of Patent: October 18, 2022Assignee: Rockwell Collins, Inc.Inventors: Patrick Gomez, Abdul A. Khan, Brian S. Rach, Charles Adams, Mitchell A. Riley, Max G. Taylor
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Publication number: 20210351988Abstract: A smart network access point (SNAP) device is disclosed. In embodiments, the SNAP device includes trunk ports for accepting a network trunk cable (e.g., fiber optic trunk) and thereby connecting the SNAP device to an aircraft-based network of SNAP devices. The SNAP device includes switch ports for incorporating physical connections to mission systems (MS) or air vehicle systems (AVS) components and devices, providing a local smart point of presence (SPoP) throughout a physical subdivision (e.g., network district) of an aircraft. The SNAP device is configured for monitoring data exchanges between local MS/AVS components and the aircraft network. The SNAP device includes a cybersecurity module for connecting to local security components (e.g., data guards and multiple levels of security (MLS) encryption/decryption) or for providing built-in data guard and encryption/decryption services. The SNAP device includes power control components for managing power distribution to the connected local network components.Type: ApplicationFiled: October 9, 2020Publication date: November 11, 2021Applicant: Rockwell Collins, Inc.Inventors: Patrick Gomez, Abdul A. Khan, Brian S. Rach, Charles Adams, Mitchell A. Riley, Max G. Taylor
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Publication number: 20210351987Abstract: A high availability aircraft network architecture incorporating smart points of presence (SPoP) is disclosed. In embodiments, the network architecture divides the aircraft into districts, or physical subdivisions. Each district includes one or more mission systems (MS) smart network access point (SNAP) devices for connecting MS components and devices located within its district to the MS network. Similarly, each district includes one or more air vehicle systems (AVS) SNAP devices for connecting AVS components and devices within the district to the AVS network. The AVS network may remain in a star or hub-and-spoke topology, while the MS network may be configured in a ring or mesh topology. Selected MS and AVS SNAP devices may be connected to each other via guarded network bridges to securely interconnect the MS and AVS networks.Type: ApplicationFiled: October 9, 2020Publication date: November 11, 2021Applicant: Rockwell Collins, Inc.Inventors: Patrick Gomez, Abdul A. Khan, Brian S. Rach, Charles Adams, Mitchell A. Riley, Max G. Taylor
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Publication number: 20190292007Abstract: A string light storage container. The string light storage container includes a base. The base defines a cylinder rising upward therefrom. The cylinder is centrally disposed in the base. The cylinder is shaped to receive string lights therearound. A cover is removably securable to the base via a fastener, such that an interior cavity is formed around the cylinder when the cover is engaged with the base.Type: ApplicationFiled: June 13, 2019Publication date: September 26, 2019Inventors: Abdul Khan, Bich Nguyen
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Publication number: 20190032561Abstract: An igniter for a combustor of a turbomachine includes a fuel inlet in fluid communication with a mixing plenum. The mixing plenum is positioned upstream of a mixing channel. An air inlet is in fluid communication with the mixing plenum and an ignition source is in operative communication with the mixing channel. The igniter may include a mounting flange configured for coupling the igniter to the combustor. The ignition source may be positioned proximate to a downstream end of the mixing channel and upstream of the mounting flange. The mixing channel may define a venturi shape. The venturi shape includes a converging section between an upstream end of the mixing channel and a venturi throat.Type: ApplicationFiled: July 31, 2017Publication date: January 31, 2019Inventors: Lucas John Stoia, Yimin Huang, Abdul Khan, Thomas Edward Johnson, Heath M. Ostebee, Jayaprakash Natarajan
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Patent number: 8607568Abstract: A combustion system includes a first combustion chamber and a second combustion chamber. The second combustion chamber is positioned downstream of the first combustion chamber. The combustion system also includes a pre-mixed, direct-injection secondary fuel nozzle. The pre-mixed, direct-injection secondary fuel nozzle extends through the first combustion chamber into the second combustion chamber.Type: GrantFiled: May 14, 2009Date of Patent: December 17, 2013Assignee: General Electric CompanyInventors: Baifang Zuo, Thomas Johnson, Willy Ziminsky, Abdul Khan
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Publication number: 20100287942Abstract: A combustion system includes a first combustion chamber and a second combustion chamber. The second combustion chamber is positioned downstream of the first combustion chamber. The combustion system also includes a pre-mixed, direct-injection secondary fuel nozzle. The pre-mixed, direct-injection secondary fuel nozzle extends through the first combustion chamber into the second combustion chamber.Type: ApplicationFiled: May 14, 2009Publication date: November 18, 2010Applicant: GENERAL ELECTRIC COMPANYInventors: Baifang Zuo, Thomas Johnson, Willy Ziminsky, Abdul Khan
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Publication number: 20070125442Abstract: An automated medication preparation system for preparing a prescribed dosage of medication in a drug delivery device includes a plurality of stations for receiving, handling and processing the drug delivery device so that the prescribed dosage of medication is delivered to the drug delivery device and a transporting device that receives and holds more than one drug delivery device and moves the drug delivery devices in a controlled manner from one station to another station. The system is configured so that two or more separate drug delivery devices can be acted upon at the same time.Type: ApplicationFiled: November 1, 2006Publication date: June 7, 2007Applicant: ForHealth Technologies, Inc.Inventors: Dennis Tribble, Joel Osborne, Abdul Khan, Edward Lefebre
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Publication number: 20070043767Abstract: A method and software interface enables selective processing of data transmissions containing one or more medication orders intended for a pharmacy. Data transmissions are monitored and parsed for prescribed information which is utilized to populate a prescribed data structure. The data structure and parsing rules can be associated with a specific source that can be determined from the data transmission. The parsed data is tested against an order database to determine suitability for automated handling. If suitable, the medication preparation system prepares the medications identified by the data. Those portions of the data that are not suited for automated handling are released (e.g., from the parser). Further verification can be performed by determining the source of the data transmission and verifying it as a valid source. Data transmissions can be monitored over a network, within a network component, or in cooperation with another software program.Type: ApplicationFiled: August 22, 2006Publication date: February 22, 2007Applicant: ForHealth Technologies, Inc.Inventors: Joel Osborne, Dennis Tribble, Abdul Khan, Matthew Valentine, Greg Olaen, Randall Rasmussen
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Patent number: D953741Type: GrantFiled: June 13, 2019Date of Patent: June 7, 2022Inventors: Abdul Khan, Bich Nguyen