Patents by Inventor Abdul R. Khokhar

Abdul R. Khokhar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7271161
    Abstract: The present invention concerns the use of methods and compositions for the treatment of cancer and other hyperproliferative diseases. In certain embodiments, methods are described for the treatment of cancer and/or hyperproliferative diseases by administration of compositions containing at least one platinum complex alone or in combination with a modulator of glutathione. In particular, the methods may be used to treat cisplatin or carboplatin resistant tumor cells.
    Type: Grant
    Filed: September 5, 2003
    Date of Patent: September 18, 2007
    Assignee: Board of Regents, the University of Texas System
    Inventors: Zahid H. Siddik, Abdul R. Khokhar
  • Patent number: 7029696
    Abstract: Antitumor compositions are disclosed, as well as methods of preparing the compositions and methods of using them to inhibit tumor growth in mammals. The invention can take advantage of intraliposomal conversion of a platinum complex having the formula where R1 is diaminocycloalkyl, and R2 and R3 each have the formula where R4, R5, and R6 are each independently hydrocarbon moieties having from 1 to about 10 carbon atoms, into a complex having the formula R1—Pt—X2??(II) where X is halogen.
    Type: Grant
    Filed: December 30, 2003
    Date of Patent: April 18, 2006
    Assignee: Board of Regents, The University of Texas System
    Inventors: Roman Perez-Soler, Abdul R. Khokhar
  • Publication number: 20040161456
    Abstract: Antitumor compositions are disclosed, as well as methods of preparing the compositions and methods of using them to inhibit tumor growth in mammals.
    Type: Application
    Filed: December 30, 2003
    Publication date: August 19, 2004
    Applicant: Board of Regents, The University of Texas System
    Inventors: Roman Perez-Soler, Abdul R. Khokhar
  • Publication number: 20040097423
    Abstract: The present invention concerns the use of methods and compositions for the treatment of cancer and other hyperproliferative diseases. In certain embodiments, methods are described for the treatment of cancer and/or hyperproliferative diseases by administration of compositions containing at least one platinum complex alone or in combination with a modulator of glutathione. In particular, the methods may be used to treat cisplatin or carboplatin resistant tumor cells.
    Type: Application
    Filed: September 5, 2003
    Publication date: May 20, 2004
    Applicant: Board of Regents, The University of Texas System
    Inventors: Zahid H. Siddik, Abdul R. Khokhar
  • Patent number: 6696079
    Abstract: Antitumor compositions are disclosed, as well as methods of preparing the compositions and methods of using them to inhibit tumor growth in mammals. The invention can take advantage of intraliposomal conversion of a platinum complex having the formula where R1 is diaminocycloalkyl, and R2 and R3 each have the formula where R4, R5, and R6 are each independently hydrocarbon moieties having from 1 to about 10 carbon atoms, into a complex having the formula R1—Pt—X2  (II) where X is halogen.
    Type: Grant
    Filed: October 8, 1998
    Date of Patent: February 24, 2004
    Assignee: Board of Regents, The University of Texas System
    Inventors: Roman Perez-Soler, Abdul R. Khokhar
  • Publication number: 20010036470
    Abstract: Antitumor compositions are disclosed, as well as methods of preparing the compositions and methods of using them to inhibit tumor growth in mammals.
    Type: Application
    Filed: October 8, 1998
    Publication date: November 1, 2001
    Inventors: ROMAN PEREZ-SOLER, ABDUL R. KHOKHAR
  • Patent number: 5843475
    Abstract: Antitumor compositions are disclosed, as well as methods of preparing the compositions and methods of using them to inhibit tumor growth in mammals. The invention can take advantage of intraliposomal conversion of a platinum complex having the formula ##STR1## where R.sub.1 is diaminocycloalkyl, and R.sub.2 and R.sub.3 each have the formula ##STR2## where R.sub.4, R.sub.5, and R.sub.6 are each independently hydrocarbon moieties having from 1 to about 10 carbon atoms,into a complex having the formulaR.sub.1 --Pt--X.sub.2where X is halogen.
    Type: Grant
    Filed: December 6, 1996
    Date of Patent: December 1, 1998
    Assignee: Board of Regents, the University of Texas System
    Inventors: Roman Perez-Soler, Abdul R. Khokhar
  • Patent number: 5434256
    Abstract: Novel 1,4 and 1,2-diaminocyclohexane platinum IV complexes have been synthesized that show activity in vivo against tumor models resistant to cis-platin and tetraplatin. The novel complexes include the chloro, acetate, trifluoroacetate, propionate, butyrate, pentanoate, hexanoate and heptanoate as leaving ligands and 1,4 or 1,2-DACH-amine ligands. The complexes showed good in vitro cytotoxic activity against murine leukemia L1210/0, L1210/DDP and L1210/DACH. High in vivo activity was shown against L1210 leukemia cells and against cis-platin resistant L1210/DDP. Excellent antitumor activity against M5076 was also exhibited by the new complexes. Additionally, the platinum complexes did not elicit any indication of nephrotoxicity in the in vivo tests.
    Type: Grant
    Filed: September 30, 1994
    Date of Patent: July 18, 1995
    Assignee: Board of Regents, The University of Texas System
    Inventors: Abdul R. Khokhar, Zahid H. Siddik
  • Patent number: 5384127
    Abstract: Lipophilic complexes having the structureDACH--Pt--R.sub.2where DACH is diaminocyclohexane, and where R is a linear alkyl carboxylato group having from about 5 to about 18 carbon atoms, have desirable stability when entrapped within lipid bilayers, and exhibit high entrapment efficiency and in vivo antitumor activity.
    Type: Grant
    Filed: December 29, 1992
    Date of Patent: January 24, 1995
    Assignee: Board of Regents, The University of Texas System
    Inventors: Roman Perez-Soler, Insook Han, Abdul R. Khokhar
  • Patent number: 5318962
    Abstract: Water-soluble complexes having the formula: ##STR1## and stereoisomers thereof, where Z.sup.1 and Z.sup.2 are halogens, and X.sup.1 and X.sup.2 are selected from the group consisting of sulfate, phosphate, nitrate, and monocarboxylate, or are jointly dicarboxylate, have been found to have desirable antitumor activity, as well as relatively low levels of toxicity.
    Type: Grant
    Filed: August 7, 1992
    Date of Patent: June 7, 1994
    Assignee: Board of Regents, The University of Texas System
    Inventors: Abdul R. Khokhar, Zahid H. Siddik, Robert A. Newman
  • Patent number: 5288887
    Abstract: Platinum(IV) complexes with mixed carboxylato ligands having the formula: ##STR1## where X.sup.1 and X.sup.2 are carboxylato, or are jointly dicarboxylato, where .sup.1 Y and Y.sup.2 are carboxylato, and where Z is either diaminocyclohexane or ethylenediamine, have been found to have desirable antitumor activity, as well as relatively low levels of toxicity.
    Type: Grant
    Filed: November 19, 1992
    Date of Patent: February 22, 1994
    Assignee: Board of Regents, The University Texas System
    Inventors: Abdul R. Khokhar, Zahid H. Siddik, Salaam Al-Baker
  • Patent number: 5186940
    Abstract: The present invention involves the synthesis and use of new platinum compounds. These new platinum compounds are easy to encapsulate in liposomes at high efficiencies. They are further characterized as platinum (II) four coordinate complex having the formula: ##STR1## wherein R.sub.1 and R.sub.2 are carboxylato monoanions bearing a hydrophobic radical function or a single carboxylato dianion bearing a hydrophobic radical function and R.sub.3 is a vicinal diaminoalkane or vicinal diaminocycloalkane. The complex is substantially soluble in methanol or chloroform and substantially insoluble in water. Said complex may be incorporated into phospholipid liposomes. Such platinum complexes encapsulated in phospholipid liposomes are useful for chemotherapy of platinum complex-sensitive tumors.
    Type: Grant
    Filed: May 31, 1991
    Date of Patent: February 16, 1993
    Assignee: The Board of Regents, The University of Texas System
    Inventors: Abdul R. Khokhar, Gabriel Lopez-Berestein, Roman Perez-Soler
  • Patent number: 5178876
    Abstract: The present invention involves the synthesis and use of new platinum compounds. These new platinum compounds are easy to encapsulate in liposomes at high efficiencies. They are further characterized as platinum (II) four coordinate complex having the formula: ##STR1## wherein R.sub.1 and R.sub.2 are carboxylato monoanions bearing a hydrophobic radical function or a single carboxylato dianion bearing a hydrophobic radical function and R.sub.3 is a vicinal diaminoalkane or vicinal diaminocycloalkane. The complex is substantially soluble in methanol or chloroform and substantially insoluble in water. Said complex may be incorporated into phospholipid liposomes. Such platinum complexes encapsulated in phospholipid liposomes are useful for chemotherapy of platinum complex-sensitive tumors.
    Type: Grant
    Filed: May 31, 1991
    Date of Patent: January 12, 1993
    Assignee: The Board of Regents, The University of Texas System
    Inventors: Abdul R. Khokhar, Gabriel Lopez-Berestein, Roman Perez-Soler
  • Patent number: 5132323
    Abstract: The invention relates to a process for the treatment of tumors in animals with water soluble square-planar cis platinum(II) four-coordinate complexes comprising different nonovalent and divalent organic cations. Monovalent cations include galacturonato and N,N-dimethylglycinato and divalent cations include citraconato, 1,1-cyclobutanedicarboxylato, 1,1-cyclopropanedicarboxylato and Z-iminodiacetato where Z is bound to the nitrogen and is ethyl, propyl, isopropyl, n-butyl, secbutyl, ter-butyl, n-amyl, isoamyl or --OH. The treatment of animals comprises administering to the animals a pharmaceutical composition comprising a platinum complex of the composition described.
    Type: Grant
    Filed: December 20, 1990
    Date of Patent: July 21, 1992
    Assignee: Board of Regents, The University of Texas System
    Inventors: Abdul R. Khokhar, Robert A. Newman, Irwin H. Krakoff
  • Patent number: 5117022
    Abstract: The present invention concerns a platinum (II) four-coordinant complex having the formula: ##STR1## wherein R.sub.1 is an alkyl diamine or cycloalkyl diamine and R.sub.2 and R.sub.3 are an alkylcarboxylato containing from five to ten carbon atoms. The R.sub.1 is preferably trans-D,L-1,2-diaminocyclohexane, trans-R,R-1,2-diaminocyclohexane, trans-S,S-1,2-diaminocyclohexane, cis-1,2-diaminocyclohexane ethylene diamine or 1,1-bis(aminomethyl)cyclohexane. The R.sub.2 and R.sub.3 are preferably neohexanoato, neoheptanoato, neononanoato, neodecanoato, neooctanoato, neopentanoato, 2-ethylhexanoato, 2-ehtylbutyrato, 2-propylpropanoato, 2-methyl-2-ethylheptanoato, 2,2-diethylhexanoato, 2,2-dimethyl-4-ethylhexanoato, 2,2-diethyl-4-methylpentanoato, 2,2-dimethyloctanoato, 2-methyl-2-ethylheptanoato, 2,2-diethylhexanoato, 2,2-diethyl-4-methylpentanoato or 2,2,4,4-tetramethylpentanoato.
    Type: Grant
    Filed: August 22, 1988
    Date of Patent: May 26, 1992
    Assignee: The Board of Regents, The University of Texas System
    Inventors: Abdul R. Khokhar, Gabriel Lopez-Berestein, Roman Perez-Soler
  • Patent number: 5053226
    Abstract: The present invention relates to monoclonal antibodies specifically binding platinum (II) complex. The monoclonal antibodies of the present invention are characteristically produced by antibody-producing cell lines such as hybridomas. These cell lines may result, for example, from fusion of a neoplastic cell with an antibody-producing animal cell obtained from an animal immunized against a platinum (II) complex. The cellular fusion products include cell lines forming monoclonal antibody specifically binding platinum (II) complex in competition with an antibody produced by: hybridoma strain 1C.sub.1 H.sub.2 A.sub.5, deposited with the American Type Culture Collection, Rockville, MD on May 1, 1987 and having ATCC accession number HB 9411; strain 3A.sub.2 A.sub.1 ; strain 1A.sub.6 A.sub.2 ; strain 3A.sub.6 B.sub.1 or strain 1B.sub.1.
    Type: Grant
    Filed: July 15, 1987
    Date of Patent: October 1, 1991
    Assignee: Board of Regents, The University of Texas System
    Inventors: Michael G. Rosenblum, James L. Murray, Peter J. Kelleher, Robert A. Newman, Abdul R. Khokhar
  • Patent number: 5041581
    Abstract: The present invention involves the synthesis and use of new platinum compounds. These new platinum compounds are easy to encapsulate in liposomes at high efficiencies. They are further characterized as platinum (II) four coordinate complex having the formula: ##STR1## wherein R.sub.1 and R.sub.2 are carboxylato monoanions bearing a hydrophobic radical function or a single carboxylato dianion bearing a hydrophobic radical function and R.sub.3 is a vicinal diaminoalkane or vicinal diaminocycloalkane. The complex is substantially soluble in methanol or chloroform and substantially insoluble in water. Said complex may be incorporated into phospholipid liposomes. Such platinum complexes encapsulated in phospholipid liposomes are useful for chemotherapy of platinum complex-sensitive tumors.
    Type: Grant
    Filed: October 7, 1986
    Date of Patent: August 20, 1991
    Assignee: The University of Texas System Board of Regents
    Inventors: Abdul R. Khokhar, Gabriel Lopez-Berestein, Roman Perez-Soler
  • Patent number: 5041578
    Abstract: Water-soluble complexes having the formula: ##STR1## and stereoisomers thereof, where Z.sup.1 and Z.sup.2 are halogens and X is selected from the group consisting of sulfate, phosphate, nitrate, monocarboxylate, and dicarboxylate, have been found to have desirable antitumor activity, as well as relatively low levels of toxicity.
    Type: Grant
    Filed: November 22, 1988
    Date of Patent: August 20, 1991
    Assignee: Board of Regents, The University of Texas System
    Inventor: Abdul R. Khokhar
  • Patent number: 5011959
    Abstract: The present invention comprises a water-soluble square-planar cis-platinum(II) four-coordinate complex having the formula:trans-R,R-DACH Pt(II) X.sub.2ortrans-R,R-DACH Pt(II) Ywherein X is a monovalvent cation, two of which are present, selected from the group consisting of cyclopropanecarboxylato, shikimato, saccharatolactone, galacturonato and N,N-dimethyglycinato; wherein Y is a divalent cation selected from the group consisting of citraconato, 1,1-cyclobutanedicarboxylato, 1,1-cyclopropanedicarboxylato, isocitratolactone and Z-iminodiacetato where Z is bound to the nitrogen and is ethyl, propyl, Isopropyl, n-butyl, sec-butyl, ter-butyl, n-amyl, isoamyl or OH.In one preferred aspect the water-soluble square-planar cis-platinum(II) four-coordinate complex has the formula:trans-R,R-DACH Pt(II) X.sub.2wherein X is a monovalent cation. Two X substituents are present in the platinum complex.
    Type: Grant
    Filed: November 17, 1986
    Date of Patent: April 30, 1991
    Assignee: The Board of Regents, The University of Texas System
    Inventors: Abdul R. Khokhar, Robert A. Newman, Irwin H. Krakoff
  • Patent number: 4758588
    Abstract: Diaminocyclohexane platinum complexes having the structural formula ##STR1## wherein: X is a monovalent anion selected from the group consisting of isoascorbate, monosaccharate, saccharate-4-lactone, shikimate, isethionate, 2-aminoethylsulfate, azetidinecarboxylate, proline, hydroxyproline, pipecolinate, cyclopropanecarboxylate, cxyclobutanecarboxylate, cyclopentanecarboxylate, cyclopentenecarboxylate, cyclohexanecarboxylate, cyclohexenecarboxylate, bicine, glycine, 2-aminoethanesulfonate, 2-chloroethanesulfonate andY is a divalent anion selected from the group consisting of iminodiacetate, isocitratelactone, furanedicarboxylate, cyclopropane-1,1-dicarboxylate, isocitratomonoethylester, N-methyliminodiacetate, N-(2-hydroxyethyl)-iminodiacetate, N-benzyliminodiacetate, N-phenyliminodiacetate, N-(2-acetamido)-iminodiacetate, cyclohexane-1,1-diacetate, trans-1,2-cyclopropanedicarboxylate, trans-1,2-cyclobutanedicarboxylate, trans-1,2-cyclopentanedicarboxylate and trans-1,2-cyclohexanedicarboxylate and their use
    Type: Grant
    Filed: February 17, 1987
    Date of Patent: July 19, 1988
    Assignee: Research Corporation Technologies
    Inventors: David B. Brown, deceased, Abdul R. Khokhar, Miles P. Hacker, John J. McCormack