Abstract: A method for making a magnetic-nanoparticle-supported catalyst includes reacting a ferrocenyl phosphine compound with an amino alcohol compound to form a ligand having a phosphine group, an amine group and at least one hydroxyl group; anchoring the ligand to a surface of magnetic nanoparticles via an oxygen atom of the hydroxyl group to form a ligand complex; combining the ligand complex with a metal precursor comprising Rh to bind the metal precursor with the ligand complex and form the magnetic-particle-supported catalyst. The magnetic-particle-supported catalyst is a Rh complex of magnetic-Fe3O4-nanoparticle-supported ferrocenyl phosphine catalyst.

Abstract: Compounds of general formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are as defined herein are useful for treating respiratory disease and other diseases and conditions modulated by TMEM16A.

Abstract: Compounds of general formula (1): wherein R1, R2, R3, R4, R5a, R* X1, X2, Z and Y are as defined herein are positive modulators of the N H calcium-activated chloride channel (CaCC), TMEM16A. The compounds are useful for treating diseases and conditions affected by modulation of TMEM16A, particularly respiratory diseases and conditions.

Abstract: Compounds of general formula (I): wherein R1, R2, R3, R4, R5a, R5b X1, X2, Z and Y are as defined herein are positive modulators of the calcium-activated chloride channel (CaCC), TMEM16A. The compounds are useful for treating diseases and conditions affected by modulation of TMEM16A, particularly respiratory diseases and conditions.

Abstract: The present disclosure provides a dump body for a machine. The dump body comprises a floor, a front wall, a pair of side walls being structured and arranged to form a material collection structure. A contoured surface being formed between at least one combination of the floor, front wall, and the pair of side walls. Further, an exhaust passage having at least a portion of wall being defined by the contoured surface is provided in the dump body, wherein the contoured surface is configured to be in fluid communication with exhaust through the exhaust passage.

Abstract: The present invention presents methods and apparatus supporting acceleration of networked applications by means of dynamic distributed execution and maintenance. It also enables management and administration of the distributed components of the networked applications from a responsible point of origination. The method and apparatus deploys a plurality of proxy servers within the network. Clients are directed to one of the proxy servers using wide area load balancing techniques. The proxy servers download programs from backend servers and cache them in a local store. These programs, in conjunction with data stored at cached servers, are used to execute applications at the proxy server, eliminating the need for a client to communicate to a backend server to execute a networked application.