Patents by Inventor Abdulhafez A. Selim

Abdulhafez A. Selim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING CORONAVIRUSES
    Publication number: 20240016874
    Abstract: Method of preventing or treating coronaviruses, such as COVID-19 infection, in a subject, comprising administering to the subject an effective amount of thymoquinone, such as an effective amount of black seed oil.
    Type: Application
    Filed: October 28, 2021
    Publication date: January 18, 2024
    Applicant: NOVATEK THERAPEUTICS, LLC
    Inventors: Abdulhafez Selim, Ahmad Omar Kaseb
  • Collagen matrix for cell therapy
    Patent number: 10603407
    Abstract: The invention relates to the use of an active collagen matrix for culturing mammalian cells and the use of the active collagen matrix and cells for the treatment of disease.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: March 31, 2020
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Abdulhafez A. Selim, Lawrence A. Shimp, Hsiu Ying Sherry Wang
  • Compositions and methods for inhibition of MMP8:MMP8-substrate interactions
    Patent number: 9969997
    Abstract: The present invention provides compounds for disrupting the binding of a matrix metalloprotease (MMP) protein to a substrate protein at an interaction site other than the protease catalytic site. In particular the inventive compounds inhibit the MMP's ability to cleave a substrate protein. In some cases the compound may prevent activation of transforming growth factor beta (TGF?). The compounds are preferably polypeptide fragments of the hemopexin-like domain of the MMP, but may be mimetics thereof or peptides or mimetics of the portion of the MMP substrate protein to which the MMP interacts.
    Type: Grant
    Filed: February 15, 2016
    Date of Patent: May 15, 2018
    Assignee: PROTEAPEX THERAPEUTICS, LLC
    Inventors: Marina D'Angelo, Abdulhafez A. Selim
  • COLLAGEN MATRIX FOR CELL THERAPY
    Publication number: 20170100511
    Abstract: The invention relates to the use of an active collagen matrix for culturing mammalian cells and the use of the active collagen matrix and cells for the treatment of disease.
    Type: Application
    Filed: December 22, 2016
    Publication date: April 13, 2017
    Inventors: Abdulhafez A. Selim, Lawrence A. Shimp, Hsiu Ying Sherry Wang
  • Compositions and methods for promoting bone formation
    Patent number: 9597431
    Abstract: A method for promoting bone formation is provided. More specifically, a method for promoting bone formation by promoting osteoclast formation is provided. In one embodiment, an implant comprising an implantable material and an osteoclast stimulating substance is provided.
    Type: Grant
    Filed: May 12, 2014
    Date of Patent: March 21, 2017
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Lawrence A. Shimp, Keyvan Behnam, Guobao Wei, Abdulhafez A. Selim
  • COMPOSITIONS AND METHODS FOR INHIBITION OF MMP:MMP-SUBSTRATE INTERACTIONS
    Publication number: 20160264955
    Abstract: The present invention provides compounds for disrupting the binding of a matrix metalloprotease (MMP) protein to a substrate protein at an interaction site other than the protease catalytic site. In particular the inventive compounds inhibit the MMP's ability to cleave a substrate protein. In some cases the compound may prevent activation of transforming growth factor beta (TGF?). The compounds are preferably polypeptide fragments of the hemopexin-like domain of the MMP, but may be mimetics thereof or peptides or mimetics of the portion of the MMP substrate protein to which the MMP interacts.
    Type: Application
    Filed: February 15, 2016
    Publication date: September 15, 2016
    Inventors: Marina D'Angelo, Abdulhafez A. Selim
  • Compounds for inhibition of MMP13-substrate interactions and methods of use thereof to treat osteoarthritis and cartilage degeneration
    Patent number: 9260707
    Abstract: The present invention provides compounds for disrupting the binding of a matrix metalloprotease (MMP) protein to a substrate protein at an interaction site other than the protease catalytic site. In particular the inventive compounds inhibit the MMP's ability to cleave a substrate protein. In some cases the compound may prevent activation of transforming growth factor beta (TGF?). The compounds are preferably polypeptide fragments of the hemopexin-like domain of the MMP, but may be mimetics thereof or peptides or mimetics of the portion of the MMP substrate protein to which the MMP interacts.
    Type: Grant
    Filed: April 28, 2014
    Date of Patent: February 16, 2016
    Assignee: PROTEAPEX THERAPEUTICS, LLC
    Inventors: Marina D'Angelo, Abdulhafez Selim
  • COMPOSITIONS AND METHODS FOR PROMOTING BONE FORMATION
    Publication number: 20150037386
    Abstract: A method for promoting bone formation is provided. More specifically, a method for promoting bone formation by promoting osteoclast formation is provided. In one embodiment, an implant comprising an implantable material and an osteoclast stimulating substance is provided.
    Type: Application
    Filed: May 12, 2014
    Publication date: February 5, 2015
    Applicant: Warsaw Orthopedic, Inc.
    Inventors: Lawrence A. Shimp, Keyvan Behnam, Guobao Wei, Abdulhafez A. Selim
  • COMPOSITIONS AND METHODS FOR INHIBITION OF MMP:MMP-SUBSTRATE INTERACTIONS
    Publication number: 20140342983
    Abstract: The present invention provides compounds for disrupting the binding of a matrix metalloprotease (MMP) protein to a substrate protein at an interaction site other than the protease catalytic site. In particular the inventive compounds inhibit the MMP's ability to cleave a substrate protein. In some cases the compound may prevent activation of transforming growth factor beta (TGF?). The compounds are preferably polypeptide fragments of the hemopexin-like domain of the MMP, but may be mimetics thereof or peptides or mimetics of the portion of the MMP substrate protein to which the MMP interacts.
    Type: Application
    Filed: April 28, 2014
    Publication date: November 20, 2014
    Inventors: Marina D'Angelo, Abdulhafez Selim
  • Compositions and methods for promoting bone formation
    Patent number: 8722075
    Abstract: A method for promoting bone formation is provided. More specifically, a method for promoting bone formation by promoting osteoclast formation is provided. In one embodiment, an implant comprising an implantable material and an osteoclast stimulating substance is provided.
    Type: Grant
    Filed: October 26, 2009
    Date of Patent: May 13, 2014
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Lawrence A. Shimp, Keyvan Behnam, Guobao Wei, Abdulhafez A. Selim
  • Compositions and methods for inhibition of MMP13:MMP-substrate interactions
    Patent number: 8710014
    Abstract: The present invention provides compounds for disrupting the binding of a matrix metalloprotease (MMP) protein to a substrate protein at an interaction site other than the protease catalytic site. In particular the inventive compounds inhibit the MMP's ability to cleave a substrate protein. In some cases the compound may prevent activation of transforming growth factor beta (TGF?). The compounds are preferably polypeptide fragments of the hemopexin-like domain of the MMP, but may be mimetics thereof or peptides or mimetics of the portion of the MMP substrate protein to which the MMP interacts.
    Type: Grant
    Filed: October 7, 2011
    Date of Patent: April 29, 2014
    Assignee: ProteaPex Therapeutics LLC
    Inventors: Marina D'Angelo, Abdulhafez Selim
  • COLLAGEN MATRIX FOR CELL THERAPY
    Publication number: 20120276203
    Abstract: The invention relates to the use of an active collagen matrix for culturing mammalian cells and the use of the active collagen matrix and cells for the treatment of disease.
    Type: Application
    Filed: April 28, 2011
    Publication date: November 1, 2012
    Applicant: WARSAW ORTHOPEDIC, INC.
    Inventors: Abdulhafez A. Selim, Lawrence A. Shimp, Hsiu Ying Sherry Wang
  • COLLAGEN MATRIX FOR TISSUE ENGINEERING
    Publication number: 20120276202
    Abstract: The invention relates to the use of an active collagen matrix for culturing mammalian cells and the use of the active collagen matrix and cells for the treatment of disease.
    Type: Application
    Filed: April 28, 2011
    Publication date: November 1, 2012
    Applicant: WARSAW ORTHOPEDIC, INC.
    Inventors: Abdulhafez A. Selim, Lawrence A. Shimp, Hsiu Ying Sherry Wang
  • COMPOSITIONS AND METHODS FOR INHIBITION OF MMP:MMP-SUBSTRATE INTERACTIONS
    Publication number: 20120088722
    Abstract: The present invention provides compounds for disrupting the binding of a matrix metalloprotease (MMP) protein to a substrate protein at an interaction site other than the protease catalytic site. In particular the inventive compounds inhibit the MMP's ability to cleave a substrate protein. In some cases the compound may prevent activation of transforming growth factor beta (TGF?). The compounds are preferably polypeptide fragments of the hemopexin-like domain of the MMP, but may be mimetics thereof or peptides or mimetics of the portion of the MMP substrate protein to which the MMP interacts.
    Type: Application
    Filed: October 7, 2011
    Publication date: April 12, 2012
    Inventors: Marina D'Angelo, Abdulhafez Selim
  • COMPOSITIONS AND METHODS FOR PROMOTING BONE FORMATION
    Publication number: 20100239634
    Abstract: A method for promoting bone formation is provided. More specifically, a method for promoting bone formation by promoting osteoclast formation is provided. In one embodiment, an implant comprising an implantable material and an osteoclast stimulating substance is provided.
    Type: Application
    Filed: October 26, 2009
    Publication date: September 23, 2010
    Inventors: Lawrence A. Shimp, Keyvan Behnam, Guobao Wei, Abdulhafez A. Selim