Abstract: A method for treating Crohn's Disease in a subject in need thereof is provided. The method includes administering rectally to the subject a therapeutically effective amount of a composition comprising roflumilast. The composition may be administered repetitively over a period of days and may contain or be co-administered with one or more agents different from roflumilast that are directed against bowel disease. A suppository dosage form comprising roflumilast and a pharmaceutically acceptable carrier are also provided.