Patents by Inventor Abdullah Ely

Abdullah Ely has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITION OF VIRAL GENE EXPRESSION
    Publication number: 20140350080
    Abstract: This invention relates to modified short interfering RNA (siRNA) nucleic acid molecules, particularly siRNA's which have been modified by the addition of a 2-0-guanidinopropyl (GP) modified nucleoside. In particular the invention relates to modified siRNAs which are capable of silencing target sequences, methods of treating and preventing infection by using the siRNAs, medicaments containing the siRNAs and use of the siRNAs.
    Type: Application
    Filed: October 26, 2012
    Publication date: November 27, 2014
    Applicant: UNIVERSITY OF THE WITWATERSRAND, JOHANNESBURG
    Inventors: Patrick Arbuthnot, Justin Hean, Abdullah Ely, Musa Marimani, Jolanta Brzezinska, Jennifer D'Onofrio, Maximilian C.R. Buff, Joachim W. Engels, Stefan Bernhardt
  • PRIMARY MICRO RNA EXPRESSION CASSETTE
    Publication number: 20100184840
    Abstract: This invention relates to inhibition of hepatitis gene expression. More specifically, the invention relates to a method of using RNA sequences to inhibit Hepatitis B and C Virus replication. Expression cassettes that include DNA sequences derived from endogenous micro RNAs (miRs) are used in the method and are transcribed by Pol II promoters, and then processed to generate sequences that are specific to target hepatitis virus sequences (RNAi effecter sequences). The RNAi effecter sequences can target the selected hepatitis virus sequences resulting in gene silencing or transcriptional inhibition of the hepatitis virus gene. The expression cassettes may be delivered in vitro or in vivo to host cells. A pharmaceutical composition containing the expression cassettes is also claimed.
    Type: Application
    Filed: November 30, 2009
    Publication date: July 22, 2010
    Applicant: University of the Witwatersrand
    Inventors: Patrick Arbuthnot, Abdullah Ely, Tanusha Naidoo, Marc Saul Weinberg, Victoria Mary Longshaw