Patents by Inventor Abdulrahman A. Almehizia

Abdulrahman A. Almehizia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cannabinoid receptor CB2 ligand 4-(aminomethyl)-N, N-dialkylanilines
    Patent number: 11059778
    Abstract: Disclosed herein are novel cannabionid receptor-2 (CB2) agonists and inverse agonists represented by Formula (I), and method of modulating the activity of CB2 by contacting the CB-2 receptor with a compound of Formula (I). Also, disclosed are methods for treating multiple myeloma or osteoporosis in a mammal in need thereof by modulating the activity of a cannabinoid receptor-2 (CB2).
    Type: Grant
    Filed: May 11, 2020
    Date of Patent: July 13, 2021
    Assignee: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Xiang-Qun Xie, Abdulrahman Almehizia, Peng Yang
  • NOVEL CANNABINOID RECEPTOR CB2 LIGAND 4-(AMINOMETHYL)-N, N-DIALKYLANILINES
    Publication number: 20200270205
    Abstract: Disclosed herein are novel cannabionid receptor-2 (CB2) agonists and inverse agonists represented by Formula (I), and method of modulating the activity of CB2 by contacting the CB-2 receptor with a compound of Formula (I). Also, disclosed are methods for treating multiple myeloma or osteoporosis in a mammal in need thereof by modulating the activity of a cannabinoid receptor-2 (CB2).
    Type: Application
    Filed: May 11, 2020
    Publication date: August 27, 2020
    Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Xiang-Qun XIE, Abdulrahman Almehizia, Peng Yang
  • Cannabinoid receptor CB2 ligand 4-(aminomethyl)-N,N-dialkylanilines
    Patent number: 10696624
    Abstract: Disclosed herein are novel cannabionid receptor-2 (CB2) agonists and inverse agonists represented by Formula (I), and method of modulating the activity of CB2 by contacting the CB-2 receptor with a compound of Formula (I). Also, disclosed are methods for treating multiple myeloma or osteoporosis in a mammal in need thereof by modulating the activity of a cannabinoid receptor-2 (CB2).
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: June 30, 2020
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Xiang-Qun Xie, Abdulrahman Almehizia, Peng Yang
  • Ursolic acid derivatives
    Patent number: 10343997
    Abstract: An ursolic acid derivative can have the following structural formula: The ursolic acid derivative exhibits potent selective calcium channel blocker activities and may be used to treat a disease or condition for which calcium channel regulation is useful.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: July 9, 2019
    Assignee: King Saud University
    Inventors: Abd El-Galil E. Amr, Mohamed A. Al-Omar, Abdulrahman A. Almehizia, Mohammed Mater Alanazi, Nawaf Abdulaziz Alsaif, Ahmad Jomah Obaidullah
  • Abietic acid derivatives as anti-tumor agents
    Patent number: 10064837
    Abstract: The abietic acid derivatives as anti-tumor agents are derivatives of abietic acid in which the hydroxyl entity (—OH) of the carboxyl entity is replaced by an electronegative substituent, which may be C6H5-O—, C6H5-S—, or C6H5-NH—, and a hydrogen atom on one of the rings is replaced by a hydroxyl (—OH) substituents, the derivatives having the formula: wherein X is O, S, or NH. The derivatives are formed by formation of an intermediate lactone from abietic acid, followed by reaction of the lactone with phenol, thiophenol, or aniline. All of the derivatives exhibited potent 5?-reductase inhibitor activity, both in vitro and in vivo, and anti-tumor activity with regard to two prostate cancer cell lines—LNCaP and PC-3. The intermediate lactones are also derivatives of abietic acid that exhibit anti-tumor activity.
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: September 4, 2018
    Assignee: KING SAUD UNIVERSITY
    Inventors: Abd El-Galil E. Amr, Mohamed A. Al-Omar, Abdulrahman A. Almehizia