Patents by Inventor Abel De La Rosa

Abel De La Rosa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutical compositions comprising substituted nucleotides and nucleosides for treating viral infections
    Patent number: 11857560
    Abstract: This disclosure relates therapeutic compositions containing a compound of Formula Im: or a pharmaceutically acceptable salt thereof, wherein R1 is as defined herein.
    Type: Grant
    Filed: October 27, 2021
    Date of Patent: January 2, 2024
    Assignee: Emory University
    Inventors: Dennis C Liotta, George R. Painter, Gregory R. Bluemling, Abel de la Rosa
  • ALKYNE CONTAINING NUCLEOTIDE AND NUCLEOSIDE THERAPEUTIC COMPOSITIONS AND USES RELATED THERETO
    Publication number: 20230062181
    Abstract: This disclosure relates to nucleotide and nucleoside therapeutic compounds and uses in treating infectious diseases viral infections, and cancer, where the base of the nucleotide or nucleoside contains at least one thiol, thione or thioether.
    Type: Application
    Filed: October 5, 2021
    Publication date: March 2, 2023
    Inventors: Gregory Bluemling, Abel de la Rosa, George Painter, Damien Kuiper, Alexander Kolykhalov
  • NUCLEOTIDE AND NUCLEOSIDE THERAPEUTIC COMPOSITIONS AND USES RELATED THERETO
    Publication number: 20220296626
    Abstract: This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in treating infectious diseases, viral infections, and cancer, where the base of the nucleotide or nucleoside contains at least one thiol, thione or thioether.
    Type: Application
    Filed: October 27, 2021
    Publication date: September 22, 2022
    Inventors: Dennis C. Liotta, George R. Painter, Gregory R. Bluemling, Abel de la Rosa
  • Phosphoramidates for the treatment of hepatitis B virus
    Patent number: 11447518
    Abstract: Disclosed are compounds to the treatment of infectious diseases and methods of treating such diseases. The compounds are derivatives of clevudine.
    Type: Grant
    Filed: April 29, 2020
    Date of Patent: September 20, 2022
    Assignee: Emory University
    Inventors: Abel de la Rosa, Gregory R. Bluemling
  • PHOSPHORAMIDATES FOR THE TREATMENT OF HEPATITIS B VIRUS
    Publication number: 20220280542
    Abstract: Disclosed are compounds and compositions to the treatment of infectious diseases and methods of treating such diseases. The compounds and compositions include derivatives of clevudine. The compounds and compositions include derivatives of clevudine in combination with another antiviral agent. The compounds and compositions include derivatives of clevudine in combination with a phosphoramnidate of lamivudine, adefovir, tenofovir, telbivudine, entecavir, or combinations thereof.
    Type: Application
    Filed: May 6, 2022
    Publication date: September 8, 2022
    Inventors: Abel DE LA ROSA, George PAINTER, Gregory R. BLUEMLING
  • Phosphoramidates for the treatment of hepatitis B virus
    Patent number: 11364257
    Abstract: Disclosed are compounds and compositions to the treatment of infectious diseases and methods of treating such diseases. The compounds and compositions include derivatives of clevudine. The compounds and compositions include derivatives of clevudine in combination with another antiviral agent. The compounds and compositions include derivatives of clevudine in combination with a phosphoramidate of lamivudine, adefovir, tenofovir, telbivudine, entecavir, or combinations thereof.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: June 21, 2022
    Assignee: Emory University
    Inventors: Abel De La Rosa, George Painter, Gregory R. Bluemling
  • PHOSPHORAMIDATES FOR THE TREATMENT OF HEPATITIS B VIRUS
    Publication number: 20210395290
    Abstract: Disclosed are compounds to the treatment of infectious diseases and methods of treating such diseases. The compounds are derivatives of clevudine.
    Type: Application
    Filed: August 2, 2021
    Publication date: December 23, 2021
    Inventors: Abel de la Rosa, Gregory R. Bluemling
  • Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto
    Patent number: 11192914
    Abstract: This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in treating infectious diseases, viral infections, and cancer, where the nucleotide or nucleoside is defined by Formula I below,
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: December 7, 2021
    Assignee: Emory University
    Inventors: Gregory Bluemling, Abel De La Rosa, George Painter, Damien Kuiper, Alexander Kolykhalov
  • Substituted nucleotides and nucleosides for treating viral infections
    Patent number: 11166973
    Abstract: This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in treating viral infections, where the base of the nucleotide or nucleoside contains at least one thiol, thione or thioether.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: November 9, 2021
    Assignee: Emory University
    Inventors: Dennis C. Liotta, George R. Painter, Gregory R. Bluemling, Abel de la Rosa
  • PHOSPHORAMIDATES FOR THE TREATMENT OF HEPATITIS B VIRUS
    Publication number: 20200299320
    Abstract: Disclosed are compounds to the treatment of infectious diseases and methods of treating such diseases. The compounds are derivatives of clevudine.
    Type: Application
    Filed: April 29, 2020
    Publication date: September 24, 2020
    Inventors: Abel de la Rosa, Gregory R. Bluemling
  • Phosphoramidates for the treatment of hepatitis B virus
    Patent number: 10683319
    Abstract: Disclosed are compounds to the treatment of infectious diseases and methods of treating such diseases. The compounds are derivatives of clevudine.
    Type: Grant
    Filed: December 7, 2015
    Date of Patent: June 16, 2020
    Assignee: Emory University
    Inventors: Abel de la Rosa, Gregory R. Bluemling
  • PHOSPHORAMIDATES FOR THE TREATMENT OF HEPATITIS B VIRUS
    Publication number: 20190350954
    Abstract: Disclosed are compounds and compositions to the treatment of infectious diseases and methods of treating such diseases. The compounds and compositions include derivatives of clevudine. The compounds and compositions include derivatives of clevudine in combination with another antiviral agent. The compounds and compositions include derivatives of clevudine in combination with a phosphoramidate of lamivudine, adefovir, tenofovir, telbivudine, entecavir, or combinations thereof.
    Type: Application
    Filed: June 23, 2017
    Publication date: November 21, 2019
    Inventors: Abel DE LA ROSA, George PAINTER, Gregory R. BLUEMLING
  • Nucleotide and Nucleoside Therapeutic Compositions and Uses Related Thereto
    Publication number: 20190298750
    Abstract: This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in treating infectious diseases, viral infections, and cancer, where the base of the nucleotide or nucleoside contains at least one thiol, thione or thioether.
    Type: Application
    Filed: November 21, 2018
    Publication date: October 3, 2019
    Inventors: Dennis C. Liotta, George R. Painter, Gregory R. Bluemling, Abel de la Rosa
  • ALKYNE CONTAINING NUCLEOTIDE AND NUCLEOSIDE THERAPEUTIC COMPOSITIONS AND USES RELATED THERETO
    Publication number: 20190144484
    Abstract: This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in treating infectious diseases, viral infections, and cancer, where the base of the nucleotide or nucleoside contains at least one thiol, thione or thioether.
    Type: Application
    Filed: April 28, 2017
    Publication date: May 16, 2019
    Inventors: Gregory BLUEMLING, Abel DE LA ROSA, George PAINTER, Damien KUIPER, Alexander KOLYKHALOV
  • NUCLEOTIDE AND NUCLEOSIDE THERAPEUTIC COMPOSITIONS AND USES RELATED THERETO
    Publication number: 20190085013
    Abstract: This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in treating infectious diseases, viral infections, and cancer, where the base of the nucleotide or nucleoside contains at least one thiol, thione or thioether.
    Type: Application
    Filed: March 7, 2017
    Publication date: March 21, 2019
    Inventors: George PAINTER, Gregory R. BLUEMLING, Abel DE LA ROSA, Dennis C. LIOTTA, Damien KUIPER
  • PHOSPHORAMIDATES FOR THE TREATMENT OF HEPATITIS B VIRUS
    Publication number: 20190062364
    Abstract: Disclosed are compounds to the treatment of infectious diseases and methods of treating such diseases. The compounds are derivatives of clevudine.
    Type: Application
    Filed: December 7, 2015
    Publication date: February 28, 2019
    Inventors: Abel de la Rosa, George Painter, Gregory R. Bluemling
  • Nucleotide and nucleoside therapeutic compositions and uses related thereto
    Patent number: 10149859
    Abstract: This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in treating infectious diseases, viral infections, and cancer, where the base of the nucleotide or nucleoside contains at least one thiol, thione or thioether.
    Type: Grant
    Filed: September 10, 2014
    Date of Patent: December 11, 2018
    Assignee: Emory University
    Inventors: Dennis C. Liotta, George R. Painter, Gregory R. Bluemling, Abel de la Rosa
  • NUCLEOTIDE AND NUCLEOSIDE THERAPEUTIC COMPOSITIONS AND USES RELATED THERETO
    Publication number: 20160220595
    Abstract: This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in treating infectious diseases, viral infections, and cancer, where the base of the nucleotide or nucleoside contains at least one thiol, thione or thioether.
    Type: Application
    Filed: September 10, 2014
    Publication date: August 4, 2016
    Inventors: Dennis C. LIOTTA, George R. PAINTER, Gregory R. BLUEMLING, Abel DE LA ROSA
  • Therapeutic composition
    Patent number: 8735345
    Abstract: Embodiments disclosed in the present application relate to a composition that can include a hepatitis C viral polymerase inhibitor, or pharmaceutically acceptable salt or prodrug thereof and a hepatitis C viral protease inhibitor, or pharmaceutically acceptable salt or prodrug thereof. Additional embodiments disclosed relate to methods for treating a disease condition such as a hepatitis C virus infection, liver fibrosis and/or impaired liver function with a hepatitis C viral polymerase inhibitor, or pharmaceutically acceptable salt or prodrug thereof and a hepatitis C viral protease inhibitor, or pharmaceutically acceptable salt or prodrug thereof.
    Type: Grant
    Filed: February 26, 2010
    Date of Patent: May 27, 2014
    Assignees: Hoffmann la Roche Inc., Pharmasset, Inc., Roche Palo Alto LLC
    Inventors: Steven B. Porter, Williamson Ziegler Bradford, Patrick F. Smith, Ellen S. Yetzer, Abel De La Rosa, Michael D. Rogers, William T. Symonds
  • Matrix and System for Preserving Biological Specimens for Qualitative and Quantitative Analysis
    Publication number: 20140038172
    Abstract: The present invention provides a device, system, and methods of use comprising an absorbent hydrophobic polyolefin matrix, and methods of use thereof, for storage, preserving, and recovering liquid suspension of biological specimens containing analytes of interest in a dry state. The dried biological specimens containing analytes of interest absorbed on the polyolefin matrix are reconstituted such as with molecular-grade water and released by compressing the polyolefin matrix. The reconstituted biological analytes are qualified for subsequent analysis, such as for qualitative and quantitative analysis of viral nucleic acids, such a viral load testing, genotyping, and sequencing. Also provided are kits with instructions, and methods of use thereof, for storage, preserving, and recovering biological specimens containing analytes of interest using the compression device of the invention.
    Type: Application
    Filed: September 6, 2013
    Publication date: February 6, 2014
    Applicant: ViveBio, LLC
    Inventors: Abel De La Rosa, Mimi C. G. Healy, Kristy S. Reece, Daniel R. McClernon, Anita Matthews McClernon