Abstract: The present invention is directed towards isolated antibodies that bind to GRP78. Specifically, compositions comprising anti-GRP78 antigen binding proteins useful in recognition of cancer or tumor cells. Moreover, in some aspects, the anti-GRP78 antigen binding proteins are useful for tumor/cancer-specific delivery of drugs and therapies. In another aspect, the disclosed antigen binding proteins are useful for enhancing radiotherapy in a subject having or suspected of having cancer or a tumor where the antigen binding protein is conjugated to a payload, for example, a therapeutic agent, an imaging agent, or a combination thereof.

Abstract: In an embodiment of the present disclosure, a processor receives a request to create a volume, wherein a volume placement policy comprises a plurality of scheduler algorithms, each of the scheduler algorithms selecting one or more worker nodes from a plurality of worker nodes for volume storage, determines, based on output from the plurality of scheduler algorithms, the one or more worker nodes, wherein output of each of the plurality of scheduler algorithms is assigned a weight in determining the one or more worker nodes; and causes a node agent in each of the one or more worker nodes to create the volume.

Abstract: Provided herein are methods and systems for improved storage strategies for use of collections of storage resources, such as solid state drives, including in connection with a converged networking and storage node that may be used for virtualization of a collection of physically attached and/or network-connected storage resources.

Abstract: Provided herein are microorganisms that include one or more heterologous nucleic acid selected from the group of a sequence encoding a 7-methylxanthosine synthase, a sequence encoding a theobromine synthase; and a sequence encoding a caffeine synthase, where the microorganism is capable of producing one or more purine alkaloid in a culture medium, when the microorganism is cultured under conditions sufficient to produce the one or more purine alkaloid. Also provided compositions and kits that include at least one of these microorganisms, and methods of producing one or more purine alkaloid that include culturing one of these microorganisms under conditions sufficient to produce the one or more purine alkaloid.

Abstract: Provided herein are methods and systems for improved storage strategies for use of collections of storage resources, such as solid state drives, including in connection with a converged networking and storage node that may be used for virtualization of a collection of physically attached and/or network-connected storage resources.

Abstract: Provided herein are methods and systems for improved storage strategies for use of collections of storage resources, such as solid state drives, including in connection with a converged networking and storage node that may be used for virtualization of a collection of physically attached and/or network-connected storage resources.

Abstract: Provided herein are methods and systems for improved storage strategies for use of collections of storage resources, such as solid state drives, including in connection with a converged networking and storage node that may be used for virtualization of a collection of physically attached and/or network-connected storage resources.

Abstract: Provided herein are methods and systems for improved storage strategies for use of collections of storage resources, such as solid state drives, including in connection with a converged networking and storage node that may be used for virtualization of a collection of physically attached and/or network-connected storage resources.

Abstract: A system and method for optimized control of an assembly for drilling a borehole comprises a self-tuning, multivariable controller and an optimization engine that manipulates the setpoints of the controller such that drilling performance may be continuously optimized. The method includes evaluation of a characteristic system time constant, using this constant to compute bit ROP, using computed ROP to compute process gains, which are used to tune the multivariable controller, automatically refining controller setpoints based on controller performance, and using an optimization engine to systematically adjust controller setpoints such that drilling parameters are optimized based on any of several performance indicators, or a weighted combination of performance indicators.

Abstract: Modified or recombinant microorganisms are provided herein that can be used to produce one or more amino acids, including, for example, methionine or one or more methionine biosynthetic pathway-derived intermediates or one or more methionine-based products.

Abstract: A system and method for optimized control of an assembly for drilling a borehole comprises a self-tuning, multivariable controller and an optimization engine that manipulates the setpoints of the controller such that drilling performance may be continuously optimized. The method includes evaluation of a characteristic system time constant, using this constant to compute bit ROP, using computed ROP to compute process gains, which are used to tune the multivariable controller, automatically refining controller setpoints based on controller performance, and using an optimization engine to systematically adjust controller setpoints such that drilling parameters are optimized based on any of several performance indicators, or a weighted combination of performance indicators.

Abstract: A system and method for optimized control of an assembly for drilling a borehole comprises a self-tuning, multivariable controller and an optimization engine that manipulates the setpoints of the controller such that drilling performance may be continuously optimized. The method includes evaluation of a characteristic system time constant, using this constant to compute bit ROP, using computed ROP to compute process gains, which are used to tune the multivariable controller, automatically refining controller setpoints based on controller performance, and using an optimization engine to systematically adjust controller setpoints such that drilling parameters are optimized based on any of several performance indicators, or a weighted combination of performance indicators.

Abstract: Provided herein are methods and systems for improved storage strategies for use of collections of storage resources, such as solid state drives, including in connection with a converged networking and storage node that may be used for virtualization of a collection of physically attached and/or network-connected storage resources.

Abstract: Provided herein are microorganisms that include one or more heterologous nucleic acid selected from the group of a sequence encoding a 7-methylxanthosine synthase, a sequence encoding a theobromine synthase; and a sequence encoding a caffeine synthase, where the microorganism is capable of producing one or more purine alkaloid in a culture medium, when the microorganism is cultured under conditions sufficient to produce the one or more purine alkaloid. Also provided compositions and kits that include at least one of these microorganisms, and methods of producing one or more purine alkaloid that include culturing one of these microorganisms under conditions sufficient to produce the one or more purine alkaloid.

Abstract: Provided herein are methods and systems for improved storage strategies for use of collections of storage resources, such as solid state drives, including in connection with a converged networking and storage node that may be used for virtualization of a collection of physically attached and/or network-connected storage resources.

Abstract: Modified or recombinant microorganisms are provided herein that can be used to produce one or more amino acids, including, for example, methionine or one or more methionine biosynthetic pathway-derived intermediates or one or more methionine-based products.

Abstract: A real time video stream production system includes: (a) an advertising insertion server receiving over a wide area network a real time video stream; and (b) an advertising controller, which receives the real time video stream from the advertising insertion server. The advertising controller has a user interface which allows an operator to cause advertising impression data available from an advertising server to be included in a modified video data stream presented to a media player client for display.

Abstract: A system and method for optimized control of an assembly for drilling a borehole comprises a self-tuning, multivariable controller and an optimization engine that manipulates the setpoints of the controller such that drilling performance may be continuously optimized. The method includes evaluation of a characteristic system time constant, using this constant to compute bit ROP, using computed ROP to compute process gains, which are used to tune the multivariable controller, automatically refining controller setpoints based on controller performance, and using an optimization engine to systematically adjust controller setpoints such that drilling parameters are optimized based on any of several performance indicators, or a weighted combination of performance indicators.

Abstract: Techniques for CDP/R services are disclosed. In one particular exemplary embodiment, the techniques may be realized as a method of transitioning continuous data protection and replication comprising determining whether a first appliance node connected to a switched fabric contains one or more transactions received from a host node, unregistering a world wide port name of a target port of the first appliance node, registering the world wide port name to a target port of a second appliance node connected to the switched fabric, associating one or more logical unit numbers of the second appliance node with the target port of the second appliance node, exporting the one or more logical unit numbers of the second appliance node, logging the target port of the second appliance node into a switched fabric, and logging the target port of the second appliance node into a remote node port of the host node.

Abstract: A recombinant microorganism employing a bacterial pathway to produce a cyclic amino acid (e.g., coronamic acid or norcoronamic acid) and a plant enzyme (ACC oxidase) to oxidize the amino acid and produce an alkene (e.g., 1-butene or propene) is provided herein. Expression of these two biosynthetic modules in various microbial chassis will facilitate alkene production from diverse energy and carbon sources, including sugars, glycerol, CO2, CH4, H2, and sunlight.