Abstract: The present disclosure relates to methods for treating patients having autoimmune diseases, e.g., methods for treating psoriatic arthritis (PsA) or axial spondyloarthritis (axSpA), e.g., non-radiographic axial spondyloarthritis (nr-axSpA) or ankylosing spondylitis (AS), using IL-17 antagonists, e.g., IL-17 antibodies, such as secukinumab. Also disclosed herein are methods for inhibiting the progression of structural damage in PsA and axSpA patients using IL-17 antagonists, e.g., IL-17 antibodies, such as secukinumab. The present disclosure also provides medicaments, pharmaceutical formulations, dosage forms, and kits for use in the disclosed methods.

Abstract: Methods, systems, and computer-readable media for utilizing radial distortion to estimate a pose configuration are disclosed. According to one aspect, the method includes receiving, from each of a plurality of camera devices, an input pixel row of a radially distorted image and conducting a row comparison between each of the input pixel rows and a respectively associated synthesized pixel row. The method further includes approximating, for each row comparison, a span of a curve in an image space with a plurality of segments and computing, for each of the plurality of segments, a constraint. The method also includes utilizing the constraints to estimate a pose configuration.