Abstract: Present invention relates to a formulation from natural product. The formulation is LDV liposomal formulation of Photo System-I (PSI) which causes apoptotic death of cancer cells through ROS generation and a simple way for targeted delivery of the said formulation specifically to melanoma cancer cell. LDV liposomal formulation of PSI was prepared for targeted delivery to melanoma cancer cell. Through this targeted delivery inventors have shown that LDV liposomal formulation of PSI specifically kills melanoma cancer cells leaving normal cells unaffected. The present invention elucidates that LDV liposomal formulation of PSI is more potent anti-cancer agent than doxorubicin for melanoma.

Abstract: Hydrogel compositions including a polymer uniformly embedded with a loading agent are provided. Also provided are methods for extrusion printing hydrogel compositions to provide extruded hydrogel compositions, which can be crosslinked to provide crosslinked hydrogel structures. Also provided are methods for using crosslinked hydrogel structures in chemical processes.

Abstract: The present investigation involves designing of a novel hexapeptide, which spontaneously self-assembles to form nanovesicles in physiological conditions. This peptide not only strongly binds with ?-tubulin near taxol binding site, but also binds with microtubule lattice in-vitro, as well as intracellular microtubule networks. Interestingly, it inhibits amyloid fibril formation upon co-incubation with A? peptide in-vitro and shows excellent neuroprotection against A? infected neuronal cell (PC12). Present invention provides a novel approach to produce a peptide-based therapeutics for neurodegenerative disease.

Abstract: Hydrogel compositions including a polymer uniformly embedded with a loading agent are provided. Also provided are methods for extrusion printing hydrogel compositions to provide extruded hydrogel compositions, which can be crosslinked to provide crosslinked hydrogel structures. Also provided are methods for using crosslinked hydrogel structures in chemical processes.

Abstract: The present investigation involves designing of a novel hexapeptide, which spontaneously self-assembles to form nanovesicles in physiological conditions. This peptide not only strongly binds with ?-tubulin near taxol binding site, but also binds with microtubule lattice in-vitro, as well as intracellular microtubule networks. Interestingly, it inhibits amyloid fibril formation upon co-incubation with A? peptide in-vitro and shows excellent neuroprotection against A? infected neuronal cell (PC12). Present invention provides a novel approach to produce a peptide-based therapeutics for neurodegenerative disease.

Abstract: A system and method for checkpoint tuning in a computer environment comprising a processor coupled to a statistical database and at least one database or table manager and data log files. The data log files store data relating to the operations of the database or table manager. The processor executes a module that captures data comprising the number of operations, the time taken by the checkpoint process, folded journal entries, long running transactions, and the ratio of WRITE:READ operations. The processor then stores the captured data and processes the collected data, generating statistics therefrom. The statistical data is stored in the statistical database. The system selects checkpoint intervals based on the data statistics; and implements the checkpoint intervals.

Abstract: A system and method for checkpoint tuning in a computer environment comprising a processor coupled to a statistical database and at least one database or table manager and data log files. The data log files store data relating to the operations of the database or table manager. The processor executes a module that captures data comprising the number of operations, the time taken by the checkpoint process, folded journal entries, long running transactions, and the ratio of WRITE:READ operations. The processor then stores the captured data and processes the collected data, generating statistics therefrom. The statistical data is stored in the statistical database. The system selects checkpoint intervals based on the data statistics; and implements the checkpoint intervals.