Patents by Inventor Abhilash N. Pillai

Abhilash N. Pillai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vanilloid fatty hydroxamates as therapeutic anti-inflammatory pharmaceuticals
    Patent number: 9422233
    Abstract: Three unique subtypes of N-hydroxyamides and N-hydroxycarbamates containing both the vanilloid moiety (4-hydroxy-3-methoxybenzyl) and a lipophilic aliphatic moiety. Also disclosed are direct syntheses of these vanilloid fatty hydroxamates. The compounds possess inhibitory activity against the enzymes fatty acid amide hydrolase (FAAH) and matrix metallo-proteinase 9 (MMP-9). In addition, these substances bind to the calcium channel protein TRPV1 and inhibit vesicant-induced inflammation in skin and cornea. The compounds have utility in treating topical or systemic inflammatory processes in the skin and/or eye.
    Type: Grant
    Filed: March 16, 2012
    Date of Patent: August 23, 2016
    Assignees: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, LEHIGH UNIVERSITY
    Inventors: Jeffrey D. Laskin, Ned D. Heindel, Carl Jeffrey Lacey, Abhilash N. Pillai, Marion Gordon, Diane E. Heck
  • Vanilloid Fatty Hydroxamates as Therapeutic Anti-inflammatory Pharmaceuticals
    Publication number: 20120252891
    Abstract: Three unique subtypes of N-hydroxyamides and N-hydroxycarbamates containing both the vanilloid moiety (4-hydroxy-3-methoxybenzyl) and a lipophilic aliphatic moiety. Also disclosed are direct syntheses of these vanilloid fatty hydroxamates. The compounds possess inhibitory activity against the enzymes fatty acid amide hydrolase (FAAH) and matrix metallo-proteinase 9 (MMP-9). In addition, these substances bind to the calcium channel protein TRPV1 and inhibit vesicant-induced inflammation in skin and cornea. The compounds have utility in treating topical or systemic inflammatory processes in the skin and/or eye.
    Type: Application
    Filed: March 16, 2012
    Publication date: October 4, 2012
    Applicants: University of Medicine and Dentistry of New Jersey, Lehigh University, Rutgers, The State University of New Jersey
    Inventors: Jeffrey D. Laskin, Ned D. Heindel, Carl Jeffrey Lacey, Abhilash N. Pillai, Marion Gordon, Diane E. Heck