Patents by Inventor Abhishek Aditham

Abhishek Aditham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR PREPARING CAPPED CIRCULAR RNA MOLECULES
    Publication number: 20250129400
    Abstract: The present disclosure provides compositions, reagents, and methods for producing capped, circular RNA molecules, circularized RNA molecules, and in particular, circularized mRNA molecules encoding a polypeptide such as a therapeutic protein.
    Type: Application
    Filed: December 23, 2024
    Publication date: April 24, 2025
    Applicants: The Broad Institute, Inc., Massachusetts Institute of Technology
    Inventors: Xiao WANG, Hongyu CHEN, Abhishek ADITHAM
  • REAGENTS AND METHODS FOR PREPARING DERIVATIZED RNA MOLECULES AND METHODS OF USE THEREOF
    Publication number: 20250121071
    Abstract: This invention provides compositions, reagents, methods, and kits for producing derivatized RNA molecules, particular mRNA molecules encoding a polypeptide and in particular a therapeutic protein, derivatized by linkage to a peptide, aptamer, synthetic DNA or RNA oligonucleotide or molecular probe, capable of targeting the derivatized RNA molecules to a particular subcellular location in a target cell.
    Type: Application
    Filed: October 30, 2024
    Publication date: April 17, 2025
    Inventors: Xiao Wang, Abhishek Aditham, Franklin Kostas
  • POLY-TAILED AND POLY-CAPPED MRNA AND USES THEREOF
    Publication number: 20240392311
    Abstract: Disclosed herein are modified mRNAs with poly(A) tails containing one or more additional poly-A tails or 5? caps, which may be made by ligation of nucleic acids onto the 3? terminal end or 5? terminal end of an RNA, respectively. Also provided are compositions comprising one or more modified mRNAs provided herein, and methods of using said compositions for therapeutic or agricultural applications.
    Type: Application
    Filed: July 17, 2024
    Publication date: November 28, 2024
    Applicants: The Broad Institute, Inc., Massachusetts Institute of Technology
    Inventors: Xiao WANG, Hongyu CHEN, Abhishek ADITHAM, Jianting GUO
  • MODIFIED MRNA, MODIFIED NON-CODING RNA, AND USES THEREOF
    Publication number: 20240277872
    Abstract: Disclosed herein are modified niRNAs and modified non-coding RNAs with poly(A) tails containing modified nucleotides and/or secondary structures, which may be made by ligation of a tailing nucleic acid onto the 3? terminal end of an RNA. Also provided are compositions comprising one or more modified mRNAs or modified non-coding RNAs provided herein, and methods of using said compositions for therapeutic or agricultural applications.
    Type: Application
    Filed: May 11, 2022
    Publication date: August 22, 2024
    Applicants: The Broad Institute, Inc., Massachusetts Institute of Technology
    Inventors: Xiao Wang, Hailing Shi, Abhishek Aditham