Abstract: Pre-moistened multi-layer wipes in which the fibrous substrate for the wipes comprises 70% or more pulp fibers. The present wipes are specifically tailored to include multiple layers that are adhered to one another with a water-resistant adhesive, e.g., which will maintain good peel strength, even when the multi-layer substrate is loaded with a cleaning composition during manufacture, and stored in such condition for an extended period (e.g., a shelf life of a year or more). The water-resistant adhesive may specifically comprise a ethylene vinyl acetate (e.g., rather than polyvinyl alcohol or other adhesives which do not adequately maintain peel strength), loaded between the layers of the substrate, e.g., up to 10 gsm. The wipe may have a peel strength of at least from 0.15 lbf-in, even after being soaked in the cleaning composition. Such pulp substrate wipes are formed from sustainable materials, while providing desired characteristics of strength and efficacy.