Abstract: Disclosed systems and methods obtain a graph of a polymer comprising nodes and edges, the nodes representing polymer atoms, the edges encoding distances and relative orientations between corresponding pairs of nodes and whether pairs of nodes are covalently bound. Each subgraph in a plurality of first partial-context subgraphs of the graph is sequentially inputted into a first model to calculate first side chain dihedral angles for polymer residues. This updates the graph through first side chain dihedral angles. Each second subgraph in a plurality of second partial-context subgraphs of the updated graph is inputted into a second model, thereby obtaining calculated second side chain dihedral angles for polymer residues that serve to update the graph through second side chain dihedral angles. The graph is again updated with updated side chain dihedral angle values obtained by sequentially inputting full-context subgraphs, each such subgraph representing a different residue, into a full-context model.

Abstract: Heterodimeric Fc variants comprising one or more asymmetric amino acid mutations in the CH2 domain and having increased selectivity of binding to Fc?RIIb as compared to a parental Fc region, polypeptides comprising the heterodimeric Fc variants and polynucleotides encoding the heterodimeric Fc variants. The one or more asymmetric mutations comprise replacement of a loop in the CH2 domain, a mutation at position 236 in the CH2 domain, or a combination of replacement of a loop in the CH2 domain and a mutation at position 236 in the CH2 domain.