Abstract: In one aspect, the present disclosure relates to an eyewear-based system and method comprised of an ocular compression device positioned around a user's head to compress the globes of a user's eyes using direct mechanical force to artificially elevate the user's intraocular pressure. An application of this system is to increase intraocular pressure in users with glaucoma or users who are at risk for glaucoma to assess novel biomarkers for glaucoma progression. The ocular compression device may be used in conjunction with an ocular imaging device, such as an optical coherence tomography angiography device, to characterize changes in the user's optic nerve head structure as a function of intraocular pressure. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.