Abstract: The present disclosure relates to compositions and methods for reducing expression of MYC gene in a cell. In some embodiments, an expression repressor comprises a targeting moiety that binds a MYC promoter, anchor sequence, or super-enhancer. In some embodiments, the expression repressor comprises an effector moiety that represses transcription or methylates DNA. Systems comprising two expression repressors are also disclosed. The compositions can be used, for example, to treat cancers such as HCC or NSCLC.

Abstract: Disclosed are assessment tools and related methods for analyzing potential transformations to a business' IT capabilities. In particular, a tool for scoping the potential opportunity incorporating a top-down approach and using previous credentials to make accurate estimations is disclosed. Additionally, a shaping tool employs a bottom-up approach to the assessment based upon more highly-detailed information of the structure of the IT department. Each tool also automatically calculates typical indices for evaluation of the business case of the IT transformation. Optionally, the tools are integrated, and also can automatically generate a business case presentation or a detailed analysis of all data involved in the assessment.