Patents by Inventor Abraham Frederik de Hulster

Abraham Frederik de Hulster has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ORGANIC ACID PRODUCTION BY FUNGAL CELLS
    Publication number: 20150104543
    Abstract: Improved systems for the biological production of organic acids are described.
    Type: Application
    Filed: September 25, 2014
    Publication date: April 16, 2015
    Inventors: Aaron Adriaan WINKLER, Abraham Frederik DE HULSTER, Johannes Pieter VAN DIJKEN, Jacobus Thomas PRONK, Joshua TRUEHEART, Kevin T. MADDEN, Carlos Gancedo RODRIGUEZ, Carmen-Lisset Flores MAURIZ, Antonius Jeroen Adriaan VAN MARIS, Jacob C. HARRISON
  • MALIC ACID PRODUCTION IN RECOMBINANT YEAST
    Publication number: 20110045559
    Abstract: The present disclosure relates to modified yeast, wherein the yeast has reduced pyruvate decarboxylase polypeptide (PDC) activity and methods of using such yeast to produce malic and/or succinic acid.
    Type: Application
    Filed: May 19, 2008
    Publication date: February 24, 2011
    Inventors: Aaron Adriaan Winkler, Abraham Frederik De Hulster, Johannes Pieter Van Dijken, Jacobus Thomas Pronk, Joshua Trueheart, Kevin T. Madden, Jacob C. Harrison, Carlos Gancedo Rodriguez, Carmen-Lisset Flores Mauriz
  • ORGANIC ACID PRODUCTION BY FUNGAL CELLS
    Publication number: 20110039327
    Abstract: Improved systems for the biological production of organic acids are described.
    Type: Application
    Filed: May 19, 2008
    Publication date: February 17, 2011
    Inventors: Aaron Adriaan Winkler, Abraham Frederik De Hulster, Johannes Pieter Van Dijken, Jacobus Thomas Pronk, Joshua Trueheart, Kevin T. Madden, Carlos Gancedo Rodriguez, Carmen-Lisset Flores Mauriz, Antonius Jeroen Adriaan Van Maris, Jacob C. Harrison
  • Malic Acid Production in Recombinant Yeast
    Publication number: 20080090273
    Abstract: We disclose a recombinant yeast, wherein the yeast is pyruvate decarboxylase enzyme (PDC) activity negative (PDC-negative) and is functionally transformed with a coding region encoding a pyruvate carboxylase enzyme (PYC) wherein the PYC is active in the cytosol, a coding region encoding a malate dehydrogenase enzyme (MDH) wherein the MDH is active in the cytosol and is not inactivated in the presence of glucose, and a coding region encoding a malic acid transporter protein (MAE). We also disclose a method of producing malic acid by culturing such a yeast in a medium comprising a carbon source and a carbon dioxide source and isolating malic acid from the medium.
    Type: Application
    Filed: October 31, 2006
    Publication date: April 17, 2008
    Inventors: Aaron Adriaan Winkler, Abraham Frederik de Hulster, Johannes Pieter van Dijken, Jacobus Thomas Pronk