Patents by Inventor Abraham LENHOFF

Abraham LENHOFF has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Reduction of lipase activity in product formulations
    Patent number: 10570397
    Abstract: The invention relates a method for producing a stable recombinant protein, comprising growing a non-naturally occurring host cell in a culture medium to produce a recombinant protein, and making a composition comprising the recombinant protein and a polysorbate. The production of endogenous lipoprotein lipase by the host cell is reduced. The endogenous lipoprotein lipase is present in the composition in a small amount, and is capable of degrading the polysorbate. The invention also relates to the relevant host cells and compositions, and preparation thereof.
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: February 25, 2020
    Assignee: University of Deleware
    Inventors: Kelvin Lee, Abraham Lenhoff, Kristin Valente, Nick Levy, Yatin Gokarn
  • REDUCTION OF LIPASE ACTIVITY IN PRODUCT FORMULATIONS
    Publication number: 20190390203
    Abstract: The invention relates a method for producing a stable recombinant protein, comprising growing a non-naturally occurring host cell in a culture medium to produce a recombinant protein, and making a composition comprising the recombinant protein and a polysorbate. The production of endogenous lipoprotein lipase by the host cell is reduced. The endogenous lipoprotein lipase is present in the composition in a small amount, and is capable of degrading the polysorbate. The invention also relates to the relevant host cells and compositions, and preparation thereof.
    Type: Application
    Filed: September 10, 2019
    Publication date: December 26, 2019
    Applicant: University of Delaware
    Inventors: Kelvin LEE, Abraham Lenhoff, Kristin Valente, Nick Levy, Yatin Gokarn
  • REDUCTION OF LIPASE ACTIVITY IN PRODUCT FORMULATIONS
    Publication number: 20180179545
    Abstract: The invention relates a method for producing a stable recombinant protein, comprising growing a non-naturally occurring host cell in a culture medium to produce a recombinant protein, and making a composition comprising the recombinant protein and a polysorbate. The production of endogenous lipoprotein lipase by the host cell is reduced. The endogenous lipoprotein lipase is present in the composition in a small amount, and is capable of degrading the polysorbate. The invention also relates to the relevant host cells and compositions, and preparation thereof.
    Type: Application
    Filed: February 15, 2018
    Publication date: June 28, 2018
    Applicant: University of Delaware
    Inventors: Kelvin LEE, Abraham Lenhoff, Kristin Valente, Nick Levy, Yatin Gokarn
  • Reduction of lipase activity in product formulations
    Patent number: 9932591
    Abstract: The invention relates a method for producing a stable recombinant protein, comprising growing a non-naturally occurring host cell in a culture medium to produce a recombinant protein, and making a composition comprising the recombinant protein and a polysorbate. The production of endogenous lipoprotein lipase by the host cell is reduced. The endogenous lipoprotein lipase is present in the composition in a small amount, and is capable of degrading the polysorbate. The invention also relates to the relevant host cells and compositions, and preparation thereof.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: April 3, 2018
    Assignee: University of Delaware
    Inventors: Kelvin Lee, Abraham Lenhoff, Kristin Valente, Nick Levy, Yatin Gokarn
  • REDUCTION OF LIPASE ACTIVITY IN PRODUCT FORMULATIONS
    Publication number: 20160312226
    Abstract: The invention relates a method for producing a stable recombinant protein, comprising growing a non-naturally occurring host cell in a culture medium to produce a recombinant protein, and making a composition comprising the recombinant protein and a polysorbate. The production of endogenous lipoprotein lipase by the host cell is reduced. The endogenous lipoprotein lipase is present in the composition in a small amount, and is capable of degrading the polysorbate. The invention also relates to the relevant host cells and compositions, and preparation thereof.
    Type: Application
    Filed: December 18, 2014
    Publication date: October 27, 2016
    Applicant: University of Delaware
    Inventors: Kelvin LEE, Abraham LENHOFF, Kristen VALENTE, Nick LEVY, Yatin GOKARN