Abstract: One or more computing devices, systems, and/or methods for implementing a model for serving exploration traffic are provided. An amount of spend by a content provider to provide content items of the content provider through a content serving platform to client devices of users is determined. A number of exploration impressions of users viewing exploration content items of the content provider over a timespan is determined. A return on exploration impression metric is determined for the content provider based upon a ratio of the amount of spend to the number of exploration impressions. The return on exploration metric is used to rank available exploration content items of content providers for serving exploration traffic.

Abstract: One or more computing devices, systems, and/or methods for isolated budget utilization are provided. A first budget pacing component is assigned to control bidding by a first content serving component for a set of content items. A second budget pacing component is assigned to control bidding by a second content serving component for the set of content items. The first budget pacing component controls the bidding by the first content serving component according to a first portion of a content item budget based upon a traffic share of the first content serving component. The second budget pacing component controls the bidding by the second content serving component according to a second portion of the content item budget based upon a traffic share of the second content serving component.

Abstract: One or more computing devices, systems, and/or methods for isolated budget utilization are provided. A first budget pacing component is assigned to control bidding by a first content serving component for a set of content items. A second budget pacing component is assigned to control bidding by a second content serving component for the set of content items. The first budget pacing component controls the bidding by the first content serving component according to a first portion of a content item budget based upon a traffic share of the first content serving component. The second budget pacing component controls the bidding by the second content serving component according to a second portion of the content item budget based upon a traffic share of the second content serving component.

Abstract: One or more computing devices, systems, and/or methods for implementing a model for serving exploration traffic are provided. An amount of spend by a content provider to provide content items of the content provider through a content serving platform to client devices of users is determined. A number of exploration impressions of users viewing exploration content items of the content provider over a timespan is determined. A return on exploration impression metric is determined for the content provider based upon a ratio of the amount of spend to the number of exploration impressions. The return on exploration metric is used to rank available exploration content items of content providers for serving exploration traffic.

Abstract: One or more computing devices, systems, and/or methods for implementing a model for serving exploration traffic are provided. An amount of spend by a content provider to provide content items of the content provider through a content serving platform to client devices of users is determined. A number of exploration impressions of users viewing exploration content items of the content provider over a timespan is determined. A return on exploration impression metric is determined for the content provider based upon a ratio of the amount of spend to the number of exploration impressions. The return on exploration metric is used to rank available exploration content items of content providers for serving exploration traffic.

Abstract: Stabilized amorphous calcium carbonate (ACC) for treatment of several neurological, muscular and infertility diseases and conditions is provided. In particular, the stabilized ACC may be used in the treatment of axonal defects and muscular dystrophy. In addition, provided are improved methods used in assistant reproductive technology. Examples of such methods are in vitro fertilization and improvement of sperm quality. The improved IVF method, for example, comprises addition of the stabilized ACC to the cell culture medium in which the stages of fertilization and embryo development occurs.

Abstract: Stabilized amorphous calcium carbonate (ACC) for treatment of several neurological, muscular and infertility diseases and conditions is provided. In particular, the stabilized ACC may be used in the treatment of axonal defects and muscular dystrophy. In addition, provided are improved methods used in assistant reproductive technology. Examples of such methods are in vitro fertilization and improvement of sperm quality. The improved IVF method, for example, comprises addition of the stabilized ACC to the cell culture medium in which the stages of fertilization and embryo development occurs.

Abstract: One or more computing devices, systems, and/or methods for implementing a model for serving exploration traffic are provided. An amount of spend by a content provider to provide content items of the content provider through a content serving platform to client devices of users is determined. A number of exploration impressions of users viewing exploration content items of the content provider over a timespan is determined. A return on exploration impression metric is determined for the content provider based upon a ratio of the amount of spend to the number of exploration impressions. The return on exploration metric is used to rank available exploration content items of content providers for serving exploration traffic.

Abstract: One or more computing devices, systems, and/or methods for determining expected revenue thresholds for presentation of content items via client devices are provided. During a first period of time, whether to present a first content item via a first client device may be determined based upon a comparison of a first expected revenue associated with the first content item with a first expected revenue threshold. A first revenue value associated with presentation of content items via client devices within the first period of time may be determined. The first expected revenue threshold may be modified to generate a second expected revenue threshold based upon the first revenue value and a target revenue value. Whether to present a second content item via a second client device may be determined based upon a comparison of a second expected revenue associated with the second content item with the second expected revenue threshold.

Abstract: One or more computing devices, systems, and/or methods for isolated budget utilization are provided. A first budget pacing component is assigned to control bidding by a first content serving component for a set of content items. A second budget pacing component is assigned to control bidding by a second content serving component for the set of content items. The first budget pacing component controls the bidding by the first content serving component according to a first portion of a content item budget based upon a traffic share of the first content serving component. The second budget pacing component controls the bidding by the second content serving component according to a second portion of the content item budget based upon a traffic share of the second content serving component.

Abstract: Stabilized amorphous calcium carbonate (ACC) for treatment of several neurological, muscular and infertility diseases and conditions is provided. In particular, the stabilized ACC may be used in the treatment of axonal defects and muscular dystrophy. In addition, provided are improved methods used in assistant reproductive technology. Examples of such methods are in vitro fertilization and improvement of sperm quality. The improved IVF method, for example, comprises addition of the stabilized ACC to the cell culture medium in which the stages of fertilization and embryo development occurs.

Abstract: Stabilized amorphous calcium carbonate (ACC) for treatment of several neurological, muscular and infertility diseases and conditions is provided. In particular, the stabilized ACC may be used in the treatment of axonal defects and muscular dystrophy. In addition, provided are improved methods used in assistant reproductive technology. Examples of such methods are in vitro fertilization and improvement of sperm quality. The improved IVF method, for example, comprises addition of the stabilized ACC to the cell culture medium in which the stages of fertilization and embryo development occurs.

Abstract: One or more computing devices, systems, and/or methods for generating bid values are provided. A content item and/or a budget associated with the content item may be identified. A target spend data structure associated with the content item may comprise a plurality of target spend values associated with a plurality of sub-periods of time within a first instance of a period of time. A first update target spend value, associated with a second instance of a first sub-period of time, may be generated based upon a first budget factor calculation associated with the first instance of the first sub-period of time and a second budget factor calculation associated with the first instance of the period of time. A first bid value for presenting the first content item at the second instance of the first sub-period of time may be generated based upon the first update target spend value.

Abstract: Stabilized amorphous calcium carbonate (ACC) as a supplement of cell culture media and the cell culture medium supplements comprising stabilized ACC are provided. In particular the stabilized ACC is useful for enhancing the growth of cell and tissue cultures, gametes and embryos in vitro.

Abstract: Stabilized amorphous calcium carbonate (ACC) for treatment of several neurological, muscular and infertility diseases and conditions is provided. In particular, the stabilized ACC may be used in the treatment of axonal defects and muscular dystrophy. In addition, provided are improved methods used in assistant reproductive technology. Examples of such methods are in vitro fertilization and improvement of sperm quality. The improved IVF method, for example, comprises addition of the stabilized ACC to the cell culture medium in which the stages of fertilization and embryo development occurs.

Abstract: The present invention relates to compositions comprising stem cells and partially committed progenitor cells and to methods of controlling cell proliferation and differentiation, which can be used for expansion of stem cells and their subsequent differentiation. The present invention provides expanded population of essentially undifferentiated stem cells, which are useful in clinical procedures involving stem cell therapy, and a population derived thereof of which at least part of the cells are differentiated. The cells can be used per se, as a part of a cell-bearing composition comprising cross-linked hyaluronic acid-laminin gels or as a part of a composite implant for tissue regeneration.

Abstract: The present invention concerns cohesive biopolymer gels comprising coprecipitates of sulfated polysaccharides and fibrillar proteins, exemplified by coprecipitates of dextran sulfate and gelatin, useful for clinical applications including as implants for tissue engineering as well as in biotechnology. The cohesive biopolymer gels according to the present invention may be used clinically either per se or as a scaffold for a cell-bearing implant, as a depot for sustained release of bioactive agents, or for research and biotechnology.

Abstract: The present invention concerns universal biocompatible matrices comprising cross-linked hyaluronic acid-laminin gels useful for clinical applications including as implants, for tissue engineering as well as in biotechnology. The gel matrices according to the present invention may be used clinically either per se or as a cell bearing implant, e.g., stem cells or endothelial cells, optionally containing bioactive molecules or drugs. The gels are particularly useful for use for transplantation or as a coating or a scaffold for use on medical devices including stents.

Abstract: The present invention concerns universal biocompatible matrices comprising cross-linked hyaluronic acid-laminin gels useful for clinical applications including as implants, for tissue engineering as well as in biotechnology. The gel matrices according to the present invention may be used clinically either per se or as a cell bearing implant, e.g. stem cells or endothelial cells, containing bioactive molecules or drugs. The gels are particularly useful for use for transplantation or as a coating or a scaffold for use on medical devices including stents.