Abstract: Disclosed herein is an aqueous colloidal titanium dioxide dispersion preferably having a pH value in a range of 6.2 to 7.8 at 25° C. and including titanium dioxide particles, the titanium particles having a Z-average particle size in a range from 30 nm to 220 nm as determined by dynamic light scattering and a particle size distribution span [(D90-D10)/(D50)] in a range from 0.7 to 1.5; one or more dispersing agents comprising groups which bind to the titanium dioxide particles; one or more organic solvents; and if necessary, one or more pH value adjusting compounds. Further disclosed herein are a method of preparing such dispersions, a coating composition containing the components of such dispersions, coated substrates and methods of coating the substrates with such dispersions and a method of using of the dispersions in the manufacture of coating compositions.

Abstract: An apparatus, such as a doorbell, may include a doorbell housing. The doorbell housing may include a front surface facing exterior of a premises and a rear surface facing interior of the premises. A camera, doorbell activator, motion sensor, and/or light source may be at least partially positioned within the doorbell housing. An antenna may be positioned within the doorbell housing. The antenna may be configured to send a wireless signal comprising data to a data receiving device inside the premises. A reflective member may be positioned within the doorbell housing and configured to reflect at least a portion of the wireless signal that is sent toward the front surface of the doorbell housing.

Abstract: An apparatus, such as a doorbell, may include a doorbell housing. The doorbell housing may include a front surface facing exterior of a premises and a rear surface facing interior of the premises. A camera, doorbell activator, motion sensor, and/or light source may be at least partially positioned within the doorbell housing. An antenna may be positioned within the doorbell housing. The antenna may be configured to send a wireless signal comprising data to a data receiving device inside the premises. A reflective member may be positioned within the doorbell housing and configured to reflect at least a portion of the wireless signal that is sent toward the front surface of the doorbell housing.

Abstract: An apparatus, such as a doorbell, may include a doorbell housing. The doorbell housing may include a front surface facing exterior of a premises and a rear surface facing interior of the premises. A camera, doorbell activator, motion sensor, and/or light source may be at least partially positioned within the doorbell housing. An antenna may be positioned within the doorbell housing. The antenna may be configured to send a wireless signal comprising data to a data receiving device inside the premises. A reflective member may be positioned within the doorbell housing and configured to reflect at least a portion of the wireless signal that is sent toward the front surface of the doorbell housing.

Abstract: The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, ring B, L, R1, R2, R3, R4, R5, Ra, Rb, n, m, p and q are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (ROR?t). These compounds prevent, inhibit, or suppress the action of ROR?t and are therefore useful in the treatment of ROR?t mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.

Abstract: The present application relates to substituted fused heteroaryl and hetero-cyclic compounds, useful as nicotinamide adenine dinucleotide phosphate oxidase inhibitors (NADPH oxidase inhibitors), processes for their preparation, pharmaceutical compositions comprising the compounds, and the use of the compounds or the compositions in the treatment or prevention of various diseases, conditions and/or disorders mediated by NADPH oxidase.

Abstract: The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, ring B, L, R1, R2, R3, R4, R5, Ra, Rb, n, m, p and q are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (ROR?t). These compounds prevent, inhibit, or suppress the action of ROR?t and are therefore useful in the treatment of ROR?t mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.

Abstract: The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, ring B, L, R1, R2, R3, R4, R5, Ra, Rb, n, m, p and q are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (ROR?t). These compounds prevent, inhibit, or suppress the action of ROR?t and are therefore useful in the treatment of ROR?t mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.

Abstract: The present disclosure is directed to novel carbocyclic compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, Ra, Rb, n, m and p are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (ROR?t). These compounds prevent, inhibit, or suppress the action of ROR?t and are therefore useful in the treatment of ROR?t mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.

Abstract: The present disclosure is directed to novel carbocyclic compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, Ra, Rb, n, m and p are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (ROR?t). These compounds prevent, inhibit, or suppress the action of ROR?t and are therefore useful in the treatment of ROR?t mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.

Abstract: The present disclosure is directed to novel carbocyclic compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, Ra, Rb, n, m and p are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (ROR?t). These compounds prevent, inhibit, or suppress the action of ROR?t and are therefore useful in the treatment of ROR?t mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.

Abstract: The present invention includes a geared orthodontic buccal tube assembly which comprises of a buccal tube with an elongated hook that engages one or more gearwheels which in turn engage a toothed surfaces to redirect the direction of the applied force pulling the buccal tube to prevent or reduce the movement of the anchor tooth thus reinforcing the anchor teeth.

Abstract: The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, ring B, L, R1, R2, R3, R4, R5, Ra, Rb, n, m, p and q are as defined herein, which are active as modulators of retinoid-related Sorphan receptor gamma t (ROR?t). These compounds prevent, inhibit, or suppress the action of ROR?t and are therefore useful in the treatment of ROR?t mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.

Abstract: The present disclosure is directed to novel carbocyclic compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, Ra, Rb, n, m and p are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (ROR?t). These compounds prevent, inhibit, or suppress the action of ROR?t and are therefore useful in the treatment of ROR?t mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.

Abstract: The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, ring B, L, R1, R2, R3, R4, R5, Ra, Rb, n, m, p and q are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (ROR?t). These compounds prevent, inhibit, or suppress the action of ROR?t and are therefore useful in the treatment of ROR?t mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.