Abstract: The present disclosure is directed toward drug coated balloons, and in particular to drug coated balloons having a microcrystalline structure and techniques for increasing vascular permeability for drug application and retention. Particular aspects may be directed to a medical device including a balloon having an outer surface, and a drug coating layer on the outer surface of the balloon. The drug coating layer includes microcrystals in a haystack orientation having random and a substantial absence of uniformity in placement and/or angle on the outer surface of the balloon.

Abstract: Endovascular devices are provided. The endovascular devices include a conformable scaffold with one or more outpocketings. The outpocketing in the endovascular device creates a corresponding outpocketing of a vessel wall, thereby altering local fluid dynamics.

Abstract: A drug delivering medical system intended for placement into a blood vessel is provided. The drug delivering medical system includes a stent device having a plurality of interconnected distinct strut elements comprising distinct strut element surfaces. At least some of the distinct strut surfaces are neither in contact with the lumen wall nor in contact with wall-contacting flow recirculation zones. The stent device releases at least one biologically active compound intended for distal delivery and provides sufficient surface area for delivering the required drug dose to a distal tissue.

Abstract: Endovascular devices are provided. The endovascular devices include a conformable scaffold with one or more outpocketings. The outpocketing in the endovascular device creates a corresponding outpocketing of a vessel wall, thereby altering local fluid dynamics.