Abstract: There are disclosed new naphthyridine- and quinoline-carboxylic acids having a 1-tertiary-alkyl substituent, compositions containing them, and their use in treating bacterial infections in warm-blooded animals. Also disclosed are novel amines and intermediates used in the preparation of the naphthyridine- and quinoline-carboxylic acids.

Abstract: There are disclosed new naphthyridine- and quinoline-carboxylic acids having a 1-tertiary-alkyl substituent, compositions containing them, and their use in treating bacterial infections in warm-blooded animals. Also disclosed are novel amines and intermediates used in the preparation of the naphthyridine- and quinoline-carboxylic acids.

Abstract: A novel crystalline monohydrate of 7-[D-.alpha.-amino-.alpha.-(p-hydroxyphenyl)acetamido]-3-methyl-3-cephem-4 -carboxylic acid is prepared and found to be a stable useful form of the cephalosporin antibiotic especially advantageous for pharmaceutical formulations.

Abstract: This invention concerns novel water-soluble compositions of the antitumor agent 4'-(9-acridinylamino)methanesulfon-m-anisidide (m-AMSA). More particularly, water-soluble compositions are provided which comprise a mixture of m-AMSA with lactic acid. The compositions enable m-AMSA to be administered as an aqueous solution without the necessity of using dimethylacetamide as a pharmaceutical vehicle.

Abstract: This invention concerns novel water-soluble compositions of 4'-(9-acridinylamino)-methanesulfon-m-anisidide (m-AMSA). More particularly, water-soluble compositions are provided which comprise a mixture of m-AMSA with lactic acid. The compositions enable m-AMSA to be administered as an aqueous solution without the necessity of using dimethylacetamide as a pharmaceutical vehicle.

Abstract: The invention concerns a crystalline monogluconate salt of the antitumor agent 4'-(9-acridinylamino)-methanesulfon-m-anisidide and compositions comprising mixtures of such salt with an organic acid selected from gluconic acid, gluconolactone or mixtures thereof. The novel salt and compositions are characterized in having unexpectedly high water-solubility.

Abstract: A novel crystalline monohydrate of 7-[D-.alpha.-amino-.alpha.-(p-hydroxyphenyl)acetamido]-3-methyl-3-cephem-4 -carboxylic acid is prepared and found to be a stable useful form of the cephalosporin antibiotic especially advantageous for pharmaceutical formulations.

Abstract: A novel crystalline monohydrate of 7-[D-.alpha.-amino-.alpha.-(p-hydroxyphenyl)acetamido]-3-methyl-3-caphem-4 -carboxylic acid is prepared and found to be a stable useful form of the cephalosporin antibiotic especially advantageous for pharmaceutical formulations.

Abstract: 7-D-.alpha.-Amino-.alpha.-(p-acetoxyphenyl)acetamido-3-methyl-3-cephem-4-ca rboxylic acid is prepared in a form substantially free of the L-isomer and hydrolyzed enzymatically, preferably using wheat bran, to produce p-hydroxycephalexin (cefadroxil).

Abstract: This invention relates to a novel .alpha.-amino.alpha.-(p-acyloxyphenyl)acetamidopenicillanic acid which is useful as an antibacterial agent, and also to a novel process for the production of 6-D-(-).alpha.-amino-.alpha.-(p-hydroxyphenylacetamido)penicillanic acid (also known as amoxycillin).BACKGROUND OF THE INVENTION1. Field of the InventionThe chemical compound of the present invention is an antibacterial agent of the class commonly called penicillins.2. Description of the Prior ArtU.S. Pat. No. 2,985,648 relates to .alpha.-aminobenzylpenicillins and discloses a general formula for such penicillins which includes, inter alia, lower alkanoyloxy substituents on the benzene ring. This document does not give any more specific details of compounds so substituted, and no specific examples are given of their preparation. The document indicates that the .alpha.-aminobenzylpenicillins exist in various optical forms and specific examples are given of the preparation of both D- and L- forms.U.S. Pat. No.

Abstract: This invention relates to certain novel .alpha.-amino- or .alpha.-formyl-.alpha.-(p-acyloxyphenyl)acetamidocephalosporanic acids which are useful as antibacterial agents.

Abstract: A novel crystalline monohydrate of 7-[D-.alpha.-amino-.alpha.-(p-hydroxyphenyl)acetamido]-3-methyl-3-caphem-4 -carboxylic acid is prepared and found to be astable useful form of the cephalosporin antibiotic especially advantageous for pharmaceutical formulations.