Patents by Inventor Abrehet Abdu

Abrehet Abdu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENGINEERED PYROCOCCUS ENZYMES AND USES THEREOF
    Publication number: 20260085299
    Abstract: Provided herein are modified Archaeal family B polymerases derived from species of the Archaeal microorganism Pyrococcus that exhibit improved incorporation of nucleotide analogues utilized in DNA sequencing.
    Type: Application
    Filed: May 27, 2025
    Publication date: March 26, 2026
    Inventors: Souad NAJI, Eli N. GLEZER, Youngjin CHO, Zachary TERRANOVA, Abrehet ABDU
  • NUCLEOTIDE ANALOGUES
    Publication number: 20250361260
    Abstract: Disclosed herein, inter alia, are compounds and methods of using the same for the modifying a nucleic acid molecule.
    Type: Application
    Filed: January 14, 2025
    Publication date: November 27, 2025
    Inventors: Eli N. Glezer, Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez, Abrehet Abdu
  • METHODS OF DARK CYCLE SEQUENCING
    Publication number: 20250290133
    Abstract: Provided herein are methods including alternating series of sequencing cycles and dark extension cycles allowing longer read lengths and addressing disadvantages of traditional nucleic acid sequencing protocols.
    Type: Application
    Filed: May 29, 2025
    Publication date: September 18, 2025
    Inventors: Eli N. Glezer, Abrehet Abdu, Timothy Looney
  • Dark cycle sequencing
    Patent number: 12404550
    Abstract: Provided herein are methods including alternating series of sequencing cycles and dark extension cycles allowing longer read lengths and addressing disadvantages of traditional nucleic acid sequencing protocols.
    Type: Grant
    Filed: August 16, 2024
    Date of Patent: September 2, 2025
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Eli N. Glezer, Abrehet Abdu, Timothy Looney
  • Engineered enzymes and uses thereof
    Patent number: 12344867
    Abstract: Provided herein are modified Archaeal family B polymerases derived from species of the Archaeal microorganism Pyrococcus that exhibit improved incorporation of nucleotide analogues utilized in DNA sequencing.
    Type: Grant
    Filed: November 9, 2023
    Date of Patent: July 1, 2025
    Assignee: SINGULAR GENOMICS SYSTEMS, INC.
    Inventors: Souad Naji, Eli N. Glezer, Youngjin Cho, Zachary Terranova, Abrehet Abdu
  • Nucleotide analogues
    Patent number: 12215122
    Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.
    Type: Grant
    Filed: November 29, 2023
    Date of Patent: February 4, 2025
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez, Abrehet Abdu, Eli N. Glezer
  • NUCLEOTIDE ANALOGUES
    Publication number: 20240400602
    Abstract: Disclosed herein, inter alia, are compounds and methods of using the same for the modifying a nucleic acid molecule.
    Type: Application
    Filed: July 31, 2024
    Publication date: December 5, 2024
    Inventors: Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez, Abrehet Abdu, Eli N. Glezer
  • METHODS FOR LONG READ SEQUENCING
    Publication number: 20240401125
    Abstract: Provided herein are methods including alternating series of sequencing cycles and dark extension cycles allowing longer read lengths and addressing disadvantages of traditional nucleic acid sequencing protocols.
    Type: Application
    Filed: August 16, 2024
    Publication date: December 5, 2024
    Inventors: Eli N. Glezer, Abrehet Abdu, Timothy Looney
  • METHODS AND COMPOSITIONS FOR REDUCING NUCLEOTIDE IMPURITIES
    Publication number: 20240401131
    Abstract: Disclosed herein, inter alia, are compositions and methods for depleting nucleotide impurities in nucleotide solutions.
    Type: Application
    Filed: August 22, 2024
    Publication date: December 5, 2024
    Inventors: Eli N. Glezer, Abrehet Abdu, Laura Ann Hale, Jiawen Li
  • Nucleotide analogues
    Patent number: 12145960
    Abstract: Disclosed herein, interalia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.
    Type: Grant
    Filed: October 24, 2019
    Date of Patent: November 19, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez, Abrehet Abdu, Eli N. Glezer
  • Methods for long read sequencing
    Patent number: 12123054
    Abstract: Provided herein are methods including alternating series of sequencing cycles and dark extension cycles allowing longer read lengths and addressing disadvantages of traditional nucleic acid sequencing protocols.
    Type: Grant
    Filed: December 8, 2021
    Date of Patent: October 22, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Eli N. Glezer, Abrehet Abdu, Timothy Looney
  • Methods and compositions for reducing nucleotide impurities
    Patent number: 12116629
    Abstract: Disclosed herein, inter alia, are compositions and methods for depleting nucleotide impurities in nucleotide solutions.
    Type: Grant
    Filed: March 22, 2023
    Date of Patent: October 15, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Abrehet Abdu, Eli N. Glezer, Laura Ann Hale, Jiawen Li
  • Methods and compositions for reducing nucleotide impurities
    Patent number: 12031179
    Abstract: Disclosed herein, inter alia, are compositions and methods for depleting nucleotide impurities in nucleotide solutions.
    Type: Grant
    Filed: November 1, 2021
    Date of Patent: July 9, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Abrehet Abdu, Eli N. Glezer, Laura Ann Hale, Jiawen Li
  • Modified Pyrococcus Polymerases and Uses Thereof
    Publication number: 20240200041
    Abstract: Provided herein are modified Archaeal family B polymerases derived from species of the Archaeal microorganism Pyrococcus that exhibit improved incorporation of nucleotide analogues utilized in DNA sequencing.
    Type: Application
    Filed: December 14, 2023
    Publication date: June 20, 2024
    Inventors: Souad Naji, Eli N. Glezer, Youngjin Cho, Zachary Terranova, Abrehet Abdu
  • ENGINEERED PYROCOCCUS ENZYMES AND USES THEREOF
    Publication number: 20240182875
    Abstract: Provided herein are modified Archaeal family B polymerases derived from species of the Archaeal microorganism Pyrococcus that exhibit improved incorporation of nucleotide analogues utilized in DNA sequencing.
    Type: Application
    Filed: November 9, 2023
    Publication date: June 6, 2024
    Inventors: Souad Naji, Eli N. Glezer, Youngjin Cho, Zachary Terranova, Abrehet Abdu
  • NUCLEOTIDE ANALOGUES
    Publication number: 20240174709
    Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.
    Type: Application
    Filed: November 29, 2023
    Publication date: May 30, 2024
    Inventors: Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez, Abrehet Abdu, Eli N. Glezer
  • Nucleotide analogues
    Patent number: 11958877
    Abstract: Disclosed herein, interalia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.
    Type: Grant
    Filed: March 6, 2023
    Date of Patent: April 16, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez, Abrehet Abdu, Eli N. Glezer
  • Modified pyrococcus polymerases and uses thereof
    Patent number: 11891633
    Abstract: Provided herein are modified Archaeal family B polymerases derived from species of the Archaeal microorganism Pyrococcus that exhibit improved incorporation of nucleotide analogues utilized in DNA sequencing.
    Type: Grant
    Filed: March 22, 2021
    Date of Patent: February 6, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Souad Naji, Eli N. Glezer, Youngjin Cho, Zachary Terranova, Abrehet Abdu
  • Engineered enzymes and uses thereof
    Patent number: 11884943
    Abstract: Provided herein are modified Archaeal family B polymerases derived from species of the Archaeal microorganism Pyrococcus that exhibit improved incorporation of nucleotide analogues utilized in DNA sequencing.
    Type: Grant
    Filed: October 5, 2021
    Date of Patent: January 30, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Souad Naji, Eli N. Glezer, Youngjin Cho, Zachary Terranova, Abrehet Abdu
  • Nucleotide analogues
    Patent number: 11878993
    Abstract: Disclosed herein, interalia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.
    Type: Grant
    Filed: April 4, 2023
    Date of Patent: January 23, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez, Abrehet Abdu, Eli N. Glezer