Patents by Inventor Abrehet Abdu

Abrehet Abdu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleotide analogues
    Patent number: 11958877
    Abstract: Disclosed herein, interalia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.
    Type: Grant
    Filed: March 6, 2023
    Date of Patent: April 16, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez, Abrehet Abdu, Eli N. Glezer
  • Modified pyrococcus polymerases and uses thereof
    Patent number: 11891633
    Abstract: Provided herein are modified Archaeal family B polymerases derived from species of the Archaeal microorganism Pyrococcus that exhibit improved incorporation of nucleotide analogues utilized in DNA sequencing.
    Type: Grant
    Filed: March 22, 2021
    Date of Patent: February 6, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Souad Naji, Eli N. Glezer, Youngjin Cho, Zachary Terranova, Abrehet Abdu
  • Engineered enzymes and uses thereof
    Patent number: 11884943
    Abstract: Provided herein are modified Archaeal family B polymerases derived from species of the Archaeal microorganism Pyrococcus that exhibit improved incorporation of nucleotide analogues utilized in DNA sequencing.
    Type: Grant
    Filed: October 5, 2021
    Date of Patent: January 30, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Souad Naji, Eli N. Glezer, Youngjin Cho, Zachary Terranova, Abrehet Abdu
  • Nucleotide analogues
    Patent number: 11878993
    Abstract: Disclosed herein, interalia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.
    Type: Grant
    Filed: April 4, 2023
    Date of Patent: January 23, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez, Abrehet Abdu, Eli N. Glezer
  • Modified polymerases and uses thereof
    Patent number: 11851687
    Abstract: Provided herein are modified Archaeal family B polymerases derived from species of the Archaeal microorganism Pyrococcus that exhibit improved incorporation of nucleotide analogues utilized in DNA sequencing.
    Type: Grant
    Filed: March 19, 2021
    Date of Patent: December 26, 2023
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Souad Naji, Eli N. Glezer, Youngjin Cho, Zachary Terranova, Abrehet Abdu
  • METHODS AND COMPOSITIONS FOR REDUCING NUCLEOTIDE IMPURITIES
    Publication number: 20230265505
    Abstract: Disclosed herein, inter alia, are compositions and methods for depleting nucleotide impurities in nucleotide solutions.
    Type: Application
    Filed: March 22, 2023
    Publication date: August 24, 2023
    Inventors: Abrehet ABDU, Eli N. GLEZER, Laura Ann HALE, Jiawen LI
  • NUCLEOTIDE ANALOGUES
    Publication number: 20230257414
    Abstract: Disclosed herein, interalia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.
    Type: Application
    Filed: April 4, 2023
    Publication date: August 17, 2023
    Inventors: Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez, Abrehet Abdu, Eli N. Glezer
  • STRAND DISPLACING AMPLIFICATION ENZYMES
    Publication number: 20230257803
    Abstract: Disclosed herein, inter alia, are novel strand-displacing polymerases and methods of use thereof.
    Type: Application
    Filed: December 21, 2022
    Publication date: August 17, 2023
    Inventors: Souad NAJI, Eli N. GLEZER, Bruna Krebs KUTCHE, Ali NIKOOMANZAR, Alexander SEVY, Caleb NEWMAN, Ryan SHULTZABERGER, Abrehet ABDU, Youngjin CHO, Janell J. KOSMATKA
  • STRAND DISPLACING SEQUENCING ENZYMES
    Publication number: 20230203578
    Abstract: Disclosed herein, inter alia, are methods, enzymes, and compositions useful for nucleic acid sequencing.
    Type: Application
    Filed: December 21, 2022
    Publication date: June 29, 2023
    Inventors: Souad NAJI, Eli N. GLEZER, Bruna Krebs KUTCHE, Ali NIKOOMANZAR, Alexander SEVY, Caleb NEWMAN, Ryan SHULTZABERGER, Abrehet ABDU, Youngjin CHO, Janell J. KOSMATKA
  • NUCLEOTIDE ANALOGUES
    Publication number: 20230203083
    Abstract: Disclosed herein, interalia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.
    Type: Application
    Filed: March 6, 2023
    Publication date: June 29, 2023
    Inventors: Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez, Abrehet Abdu, Eli N. Glezer
  • NUCLEOTIDE ANALOGUES
    Publication number: 20230028359
    Abstract: Disclosed herein, interalia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.
    Type: Application
    Filed: October 24, 2019
    Publication date: January 26, 2023
    Inventors: Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez, Abrehet Abdu, Eli N. Glezer
  • METHODS FOR LONG READ SEQUENCING
    Publication number: 20220170092
    Abstract: Provided herein are methods including alternating series of sequencing cycles and dark extension cycles allowing longer read lengths and addressing disadvantages of traditional nucleic acid sequencing protocols.
    Type: Application
    Filed: December 8, 2021
    Publication date: June 2, 2022
    Inventors: Eli N. GLEZER, Abrehet ABDU, Timothy LOONEY
  • METHODS AND COMPOSITIONS FOR REDUCING NUCLEOTIDE IMPURITIES
    Publication number: 20220136048
    Abstract: Disclosed herein, inter alia, are compositions and methods for depleting nucleotide impurities in nucleotide solutions.
    Type: Application
    Filed: November 1, 2021
    Publication date: May 5, 2022
    Inventors: Abrehet ABDU, Eli N. GLEZER, Laura Ann HALE, Jiawen LI
  • MODIFIED PYROCOCCUS POLYMERASES AND USES THEREOF
    Publication number: 20220119779
    Abstract: Provided herein are modified Archaeal family B polymerases derived from species of the Archaeal microorganism Pyrococcus that exhibit improved incorporation of nucleotide analogues utilized in DNA sequencing.
    Type: Application
    Filed: March 22, 2021
    Publication date: April 21, 2022
    Inventors: Souad NAJI, Eli N. GLEZER, Youngjin CHO, Zachary TERRANOVA, Abrehet ABDU
  • ENGINEERED PYROCOCCUS ENZYMES AND USES THEREOF
    Publication number: 20220119780
    Abstract: Provided herein are modified Archaeal family B polymerases derived from species of the Archaeal microorganism Pyrococcus that exhibit improved incorporation of nucleotide analogues utilized in DNA sequencing.
    Type: Application
    Filed: October 5, 2021
    Publication date: April 21, 2022
    Inventors: Souad NAJI, Eli N. GLEZER, Youngjin CHO, Zachary TERRANOVA, Abrehet ABDU
  • Methods for long read sequencing
    Patent number: 11225688
    Abstract: Provided herein are methods including alternating series of sequencing cycles and dark extension cycles allowing longer read lengths and addressing disadvantages of traditional nucleic acid sequencing protocols.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: January 18, 2022
    Assignee: SINGULAR GENOMICS SYSTEMS, INC.
    Inventors: Eli N. Glezer, Abrehet Abdu, Timothy Looney
  • MODIFIED PYROCOCCUS POLYMERASES AND USES THEREOF
    Publication number: 20210284975
    Abstract: Provided herein are modified Archaeal family B polymerases derived from species of the Archaeal microorganism Pyrococcus that exhibit improved incorporation of nucleotide analogues utilized in DNA sequencing.
    Type: Application
    Filed: March 19, 2021
    Publication date: September 16, 2021
    Inventors: Souad NAJI, Eli N. GLEZER, Youngjin CHO, Zachary TERRANOVA, Abrehet ABDU
  • METHODS FOR LONG READ SEQUENCING
    Publication number: 20210189481
    Abstract: Provided herein are methods including alternating series of sequencing cycles and dark extension cycles allowing longer read lengths and addressing disadvantages of traditional nucleic acid sequencing protocols.
    Type: Application
    Filed: December 18, 2020
    Publication date: June 24, 2021
    Inventors: Eli N. GLEZER, Abrehet ABDU, Timothy LOONEY
  • Modified pyrococcus polymerases and uses thereof
    Patent number: 11034942
    Abstract: Provided herein are modified Archaeal family B polymerases derived from species of the Archaeal microorganism Pyrococcus that exhibit improved incorporation of nucleotide analogues utilized in DNA sequencing.
    Type: Grant
    Filed: February 27, 2020
    Date of Patent: June 15, 2021
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Souad Naji, Eli N. Glezer, Youngjin Cho, Zachary Terranova, Abrehet Abdu
  • Nucleotide analogues
    Patent number: 10738072
    Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.
    Type: Grant
    Filed: October 24, 2019
    Date of Patent: August 11, 2020
    Assignee: SINGULAR GENOMICS SYSTEMS, INC.
    Inventors: Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez, Abrehet Abdu, Eli N. Glezer