Patents by Inventor Abu Alam
Abu Alam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150202321Abstract: The present disclosure relates to nanosized chitosan-statin conjugates, nanosized chitosan-chemotherapeutic agent conjugates, compositions comprising such nanosized chitosan-drug conjugates, and methods of making and using the same. The compositions result in unexpected and dramatic improved bioavailability of the component statin or chemotherapeutic agent.Type: ApplicationFiled: August 14, 2013Publication date: July 23, 2015Applicant: NEWGEN BIOPHARMA CORP.Inventors: Abu Alam, Navdeep Jaikaria, Gaurav K. Jain, Farhan J. Ahmad
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Patent number: 8759401Abstract: Disclosed is a stable aqueous gel formulation suitable for topical use comprising water, an anesthetic (e.g., lidocaine hydrochloride), a viscoelastic polymer, and a tonicity modifier, wherein the aqueous gel formulation is free of preservatives and phosphate buffer, is isotonic with physiological fluids, and is sterile and has low particulate count. Also disclosed is a method of inducing topical anesthesia on a tissue or organ, e.g., the eye, of an animal comprising providing a stable aqueous gel formulation comprising water, an anesthetic, a viscoelastic polymer, and a tonicity modifier, wherein the aqueous gel formulation is free of preservatives and phosphate buffer, is isotonic with physiological fluids, and is sterile, and topically administering an effective amount of the aqueous gel formulation to the tissue or organ of the animal.Type: GrantFiled: August 7, 2013Date of Patent: June 24, 2014Assignee: Akorn, Inc.Inventors: Abu Alam, Elias Reichel, Brandon Busbee
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Publication number: 20130324612Abstract: Disclosed is a stable aqueous gel formulation suitable for topical use comprising water, an anesthetic (e.g., lidocaine hydrochloride), a viscoelastic polymer, and a tonicity modifier, wherein the aqueous gel formulation is free of preservatives and phosphate buffer, is isotonic with physiological fluids, and is sterile and has low particulate count. Also disclosed is a method of inducing topical anesthesia on a tissue or organ, e.g., the eye, of an animal comprising providing a stable aqueous gel formulation comprising water, an anesthetic, a viscoelastic polymer, and a tonicity modifier, wherein the aqueous gel formulation is free of preservatives and phosphate buffer, is isotonic with physiological fluids, and is sterile, and topically administering an effective amount of the aqueous gel formulation to the tissue or organ of the animal.Type: ApplicationFiled: August 7, 2013Publication date: December 5, 2013Applicant: Akorn, Inc.Inventors: Abu Alam, Elias Reichel, Brandon Busbee
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Publication number: 20120034307Abstract: Disclosed is a stable aqueous gel formulation suitable for topical use comprising water, an anesthetic (e.g., lidocaine hydrochloride), a viscoelastic polymer, and a tonicity modifier, wherein the aqueous gel formulation is free of preservatives and phosphate buffer, is isotonic with physiological fluids, and is sterile and has low particulate count. Also disclosed is a method of inducing topical anesthesia on a tissue or organ, e.g., the eye, of an animal comprising providing a stable aqueous gel formulation comprising water, an anesthetic, a viscoelastic polymer, and a tonicity modifier, wherein the aqueous gel formulation is free of preservatives and phosphate buffer, is isotonic with physiological fluids, and is sterile, and topically administering an effective amount of the aqueous gel formulation to the tissue or organ of the animal.Type: ApplicationFiled: October 20, 2011Publication date: February 9, 2012Applicant: AKORN, INC.Inventors: Abu Alam, Elias Reichel, Brandon Busbee
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Publication number: 20090123527Abstract: Disclosed is a method of inducing topical anesthesia in a tissue or organ of an animal comprising providing an aqueous gel formulation comprising water, an anesthetic (e.g., lidocaine hydrochloride), a viscoelastic polymer, and a tonicity modifier, wherein the aqueous gel formulation is free of preservatives and phosphate buffer, is isotonic with physiological fluids, and is sterile and has low particulate count. Also disclosed are a transdermal patch comprising the aqueous gel formulation suitable for applying on the skin of a patient and a method of controlling pain therewith.Type: ApplicationFiled: January 15, 2009Publication date: May 14, 2009Applicant: Akorn, Inc.Inventors: ABU ALAM, Elias Reichel, Brandon Busbee
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Publication number: 20080021068Abstract: Disclosed is a stable aqueous gel formulation suitable for topical use comprising water, an anesthetic (e.g., lidocaine hydrochloride), a viscoelastic polymer, and a tonicity modifier, wherein the aqueous gel formulation is free of preservatives and phosphate buffer, is isotonic with physiological fluids, and is sterile and has low particulate count. Also disclosed is a method of inducing topical anesthesia on a tissue or organ, e.g., the eye, of an animal comprising providing a stable aqueous gel formulation comprising water, an anesthetic, a viscoelastic polymer, and a tonicity modifier, wherein the aqueous gel formulation is free of preservatives and phosphate buffer, is isotonic with physiological fluids, and is sterile, and topically administering an effective amount of the aqueous gel formulation to the tissue or organ of the animal.Type: ApplicationFiled: July 24, 2006Publication date: January 24, 2008Applicant: Akorn, Inc.Inventors: Abu Alam, Elias Reichel, Brandon Busbee
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Publication number: 20080020044Abstract: Disclosed is a stable aqueous gel formulation suitable for topical use comprising water, an anesthetic (e.g., lidocaine hydrochloride), a viscoelastic polymer, and a tonicity modifier, wherein the aqueous gel formulation is free of preservatives and phosphate buffer, is isotonic with physiological fluids, and is sterile and has low particulate count. Also disclosed is a method of inducing topical anesthesia on a tissue or organ, e.g., the eye, of an animal comprising providing a stable aqueous gel formulation comprising water, an anesthetic, a viscoelastic polymer, and a tonicity modifier, wherein the aqueous gel formulation is free of preservatives and phosphate buffer, is isotonic with physiological fluids, and is sterile, and topically administering an effective amount of the aqueous gel formulation to the tissue or organ of the animal.Type: ApplicationFiled: May 7, 2007Publication date: January 24, 2008Applicant: Akorn, Inc.Inventors: Abu Alam, Elias Reichel, Brandon Busbee
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Publication number: 20050249820Abstract: The invention provides a nutritional supplement in the form of one or more capsules comprising Vitamin A, Vitamin C, Vitamin E, and at least one carotenoid. The invention also provides a nutritional supplement in the form of one or more capsules comprising Vitamin A, Vitamin C, Vitamin E, zinc, copper, and at least one carotenoid. The invention further provides a method for the treatment and/or prevention of macular degeneration comprising the step of orally administering to a patient the nutritional supplement of the invention.Type: ApplicationFiled: May 4, 2004Publication date: November 10, 2005Applicant: Akorn, Inc.Inventor: Abu Alam
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Patent number: 6944493Abstract: Aqueous indocyanine green (ICG) composition exhibiting enhanced stability, as well as enhanced ICG concentration, as compared to presently available ICG products. The composition comprises an aqueous ICG composition comprising ICG at a concentration of at least about 10 mg/ml and an aqueous diluent, wherein the composition is stable for at least 24 hours. Diagnostic and therapeutic methods for using these aqueous compositions are also contemplated, e.g., angiography, dye-enhanced photocoagulation, photodynamic therapy, for a variety of conditions, including Age-Related Macular Degeneration (ARMD), lesions and tumors.Type: GrantFiled: December 27, 2001Date of Patent: September 13, 2005Assignee: Akora, Inc.Inventors: Abu Alam, Ashok J. Chavan, Robert W. Flower
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Publication number: 20040186084Abstract: Sterile compositions comprising triamcinolone compounds (desirably, triamcinolone acetonide), systems for providing such compositions, and methods for the preparation and use of such compositions. Exemplary of the inventive compositions is a sterile aqueous composition comprising triamcinolone acetonide, wherein the sterile aqueous composition has a pH of between about 5 and 7.5 and contains no more than 1 wt. % excipients other than tonicity-adjusting agents and pH-adjusting agents.Type: ApplicationFiled: March 21, 2003Publication date: September 23, 2004Applicant: Akorn, Inc.Inventors: Abu Alam, Hari Menon
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Publication number: 20040156782Abstract: Methods of using indocyanine green (ICG) dye for obtaining angiographic images of tissue in a patient, determining cardiac output or hepatic function and liver blood flow, and diagnosing and treating a lesion. In each method, an aqueous ICG composition is administered to the patient more than 10 hours after the ICG has been reconstituted to form the aqueous ICG composition, and up to a maximum time limit as determined using HPLC analysis of ICG.Type: ApplicationFiled: February 12, 2003Publication date: August 12, 2004Applicant: Akorn, Inc.Inventors: Abu Alam, Ashok J. Chavan
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Publication number: 20030060718Abstract: Aqueous indocyanine green (ICG) composition exhibiting enhanced stability, as well as enhanced ICG concentration, as compared to presently available ICG products. The composition comprises an aqueous ICG composition comprising ICG at a concentration of at least about 10 mg/ml and an aqueous diluent, wherein the composition is stable for at least 24 hours. Diagnostic and therapeutic methods for using these aqueous compositions are also contemplated, e.g., angiography, dye-enhanced photocoagulation, photodynamic therapy, for a variety of conditions, including Age-Related Macular Degeneration (ARMD), lesions and tumors.Type: ApplicationFiled: December 27, 2001Publication date: March 27, 2003Applicant: Akorn, Inc.Inventors: Abu Alam, Ashok J. Chavan, Robert W. Flower
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Patent number: 6443976Abstract: Use of radiation-absorbing dyes (e.g., indocyanine green (ICG), fluorescein, rose bengal) and photodynamic dyes (e.g., hematoporphyrins, aminolevulinic acids, porphyrins, merocyanines, porphycenes, porfimer sodium, verteporfin, Photofrin II, PH-10, chlorins, zinc phthalocyanine, purpurins, pheophorbides, monoclonal antibody-dye conjugates of any of the foregoing dyes) for the treatment of conditions associated with abnormal vasculature, including, generally, lesions, and, more specifically, tumors (cancerous and benign) and choroidal neovascularization (CNV) associated with age-related macular degeneration (ARMD).Type: GrantFiled: November 30, 1999Date of Patent: September 3, 2002Assignee: Akorn, Inc.Inventors: Robert W. Flower, Abu Alam
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Patent number: 6351663Abstract: Methods concerning medical uses for fluorescent dyes, e.g., Indocyanine green (ICG), fluorescein, rose bengal, for diagnosis and treatment. Methods for enhancing the clarity of fluorescent dye angiograms using relatively high dye concentrations, methods for determining the direction of blood flow within a blood vessel using fluorescent dye angiograms, and methods of identifying blood vessels that feed a lesion, such as a CNV or tumor. Methods of reducing the flow of blood into lesions incorporating dye-enhanced photocoagulation are also provided.Type: GrantFiled: September 10, 1999Date of Patent: February 26, 2002Assignee: Akorn, Inc.Inventors: Robert W. Flower, Abu Alam
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Patent number: 5997884Abstract: An aqueous solution of droperidol suitable for injection having a concentration from about 0.1 to about 10.0 mg/ml, and a sufficient amount of tonicity adjusting agent to render the solution isotonic, the solution being in a sealed container. Also provided is an aqueous solution of droperidol suitable for injection, comprising droperidol at a concentration from about 2.75 to about 10 mg/ml, and the solution being in a sealed container.Type: GrantFiled: February 12, 1998Date of Patent: December 7, 1999Assignee: Taylor PharmaceuticalsInventors: Abu Alam, Pablo J. Diaz Cruz, Keith Glad, Dennis Roberts
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Patent number: 5990134Abstract: Oral dosage form of droperidol are provided and a method for treating migraine using such oral formulations. The dosage forms include tablets, capsules, powders, effervescent formulations and syrups.Type: GrantFiled: August 12, 1998Date of Patent: November 23, 1999Assignee: Taylor PharmaceuticalsInventor: Abu Alam
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Patent number: 5981552Abstract: Sublingual and buccal dosage forms of droperidol are provided in a method for treating migraine using such formulations.Type: GrantFiled: October 23, 1998Date of Patent: November 9, 1999Assignee: Taylor PharmaceuticalsInventor: Abu Alam