Abstract: A pharmaceutical composition is provided for the oral administration of an NSAlD and a prostaglandin. The composition is a solid dosage form wherein the NSAID is enterically coated and the prostaglandin is present along with an effective stabilizing amount of a prostaglandin stabilizing agent such as hydroxypropyl methylcellulose or polyvinylpyrrolidone. Exemplary dosage forms are bilayer tablets in which the prostaglandin is misoprostol and the NSAID is diclofenac, piroxicam, or a pharmaceutically acceptable salt thereof. Methods for using the composition to treat NSAID-responsive conditions, disorders and diseases are provided as well.

Abstract: A cooling system (10) for a turbocharged locomotive engine (12) including a two stage intercooler (20) for conditioning the combustion air (16). A first coolant loop (32) includes a first stage intercooler (38), the engine coolant passages (22), a radiator (34), a first tank (36), an oil cooler (30), and a first pump (40). A second coolant loop (42) includes a second stage intercooler (44) a subcooler (48), a second tank (46), and a second pump (50). A fluid connection is provided between the first coolant loop (32) and the second coolant loop (42) to provide heat there between during conditions of overcooling of the second coolant loop (42). Flow control valves forming a portion of first coolant loop (32) may be embodied in a single rotor-sleeve flow control valve (130).

Abstract: A pharmaceutical composition is provided for the oral administration of an NSAID and a prostaglandin. The composition is a solid dosage form wherein the NSAID is enterically coated and the prostaglandin is present along with an effective stabilizing amount of a prostaglandin stabilizing agent such as hydroxypropyl methylcellulose or polyvinylpyrrolidone. Exemplary dosage forms are bilayer tablets in which the prostaglandin is misoprostol and the NSAID is diclofenac, piroxicam, or a pharmaceutically acceptable salt thereof. Methods for using the composition to treat NSAID-responsive conditions, disorders and diseases are provided as well.