Patents by Inventor Achim Harder

Achim Harder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5856324
    Abstract: The present invention relates to the use of dioxomorpholines of the formula (I) ##STR1## in which the radicals R.sup.1 to R.sup.5 have the meanings given in the description, their use for combating endoparasites and new dioxomorpholines and processes for their preparation.
    Type: Grant
    Filed: May 2, 1997
    Date of Patent: January 5, 1999
    Assignee: Bayer Aktiengesellschaft
    Inventors: Andrew Plant, Jurgen Scherkenbeck, Peter Jeschke, Achim Harder, Norbert Mencke
  • Patent number: 5821222
    Abstract: The present invention relates to the use of cyclic depsipeptides having 18 ring atoms of the general formula (I) ##STR1## in which R.sup.1 to R.sup.6 have the meaning given in the description, and to their optical isomers and racemates, in medicine and veterinary medicine for combating endoparasites, to their preparation, and to new cyclic depsipeptides having 18 ring atoms.
    Type: Grant
    Filed: October 9, 1996
    Date of Patent: October 13, 1998
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gerhard Bonse, Michael Londershausen, Erwin Bischoff, Hartwig Muller, Achim Harder, Nobert Mencke, Peter Kurka, Peter Jeschke, Jurgen Scherkenbeck
  • Patent number: 5777075
    Abstract: The present invention relates to the use of open-chain octadepsipeptides of the general formula: ##STR1## wherein the R variables have been defined in the specification.
    Type: Grant
    Filed: August 1, 1995
    Date of Patent: July 7, 1998
    Assignee: Bayer Aktiengesellschaft
    Inventors: Jurgen Scherkenbeck, Peter Jeschke, Hans-Georg Lerchen, Hermann Hagemann, Achim Harder, Norbert Mencke, Andrew Plant
  • Patent number: 5717063
    Abstract: The present invention relates to compounds of the general formula (I) ##STR1## in which R.sup.1 and R.sup.12 represent the same or different radicals selected from the group of C.sub.2-9 -alkyl, C.sub.1-8 -halogeno-alkyl, C.sub.3-6 -cycloalkyl, aralkyl or aryl,R.sup.3 to R.sup.10 represent the same or different radicals selected from the group of hydrogen, C.sub.1-5 -alkyl which may optionally be substituted by hydroxyl, alkoxy, carboxyl, carboxamide, imidazolyl, indolyl, guanidino, thio- or thioalkyl, and represent aryl, alkylaryl or heteroarylmethyl which are optionally substituted by halogen, hydroxyl, alkyl, alkoxy, nitro or a --NR.sup.13 R.sup.14 group in which R.sup.13 or R.sup.14 independently from each other represent hydrogen or alkyl or together with the adjoining nitrogen atom form a 5, 6 or 7-membered ring which is optionally interrupted by O, S or N and which is optionally substituted by C.sub.1-4 -alkyl,R.sup.2 and R.sup.11 represent the same of different radicals selected from the group of C.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: February 10, 1998
    Assignee: Bayer Aktiengesellschaft
    Inventors: Jurgen Scherkenbeck, Peter Jeschke, Hans-Georg Lerchen, Hermann Hagemann, Achim Harder, Norbert Mencke, Andrew Plant
  • Patent number: 5712295
    Abstract: Use of agonists and antagonists of the nicotinergic acetylcholine receptors of insects for combating endoparasites is disclosed.
    Type: Grant
    Filed: November 21, 1996
    Date of Patent: January 27, 1998
    Assignee: Bayer Aktiengesellschaft
    Inventors: Norbert Mencke, Achim Harder, Terence Hopkins
  • Patent number: 5663140
    Abstract: The present invention relates to the use of cyclic depsipeptides having 12 ring atoms of the general formula (I) ##STR1## in which R.sup.1 and R.sup.4 independently of one another represent hydrogen, straight-chain or branched alkyl, cycloalkyl, aralkyl, aryl, heteroaryl or heteroarylalkyl, each of which is optionally substituted,R.sup.2, R.sup.3, R.sup.5 and R.sup.
    Type: Grant
    Filed: January 13, 1995
    Date of Patent: September 2, 1997
    Assignee: Bayer Aktiengesellschaft
    Inventors: Jurgen Scherkenbeck, Peter Jeschke, Andrew Plant, Achim Harder, Norbert Mencke
  • Patent number: 5656464
    Abstract: The present invention relates to a process for the preparation of lactic-acid-containing, optically active, cyclic depsipeptides having 18 ring atoms with the aid of fungal strains of the species Fusarium or enzymatic preparations isolated therefrom.
    Type: Grant
    Filed: February 17, 1995
    Date of Patent: August 12, 1997
    Assignee: Bayer Aktiengesellschaft
    Inventors: Peter Jeschke, Achim Harder, Norbert Mencke, Horst Kleinkauf, Rainer Zocher
  • Patent number: 5624897
    Abstract: New cyclic depsipeptides having 18 ring atoms, of the general formula (I) ##STR1## in which R represents hydrogen, straight-chain or branched or cyclic alkyl having up to 8 carbon atoms,and their optical isomers and racemates,and their use for combating endoparasites in the field of medicine and veterinary medicine.
    Type: Grant
    Filed: December 9, 1994
    Date of Patent: April 29, 1997
    Assignee: Bayer Aktiengesellschaft
    Inventors: Peter Jeschke, Jurgen Scherkenbeck, Gerhard Bonse, Erwin Bischoff, Norbert Mencke, Achim Harder, Michael Londershausen, Hartwig Muller
  • Patent number: 5589503
    Abstract: The present invention relates to the use of praziquantel and epsiprantel for enhancing the endoparasiticidal activity of cyclic depsipeptides in endoparasiticidal compositions.
    Type: Grant
    Filed: January 4, 1995
    Date of Patent: December 31, 1996
    Assignee: Bayer Aktiengesellschaft
    Inventors: Norbert Mencke, Achim Harder, Peter Jeschke
  • Patent number: 5585493
    Abstract: Substituted 1,2,4-oxadiazole derivatives of the formula (I) and their stereoisomers ##STR1## in which formula R.sup.1 represents hydrogen, C.sub.1-8 -alkyl which is optionally substituted by halogen, cycloalkyl, alkoxy, hydroxyl, aryl, alkylcarbonyl, alkoxycarbonyl and cycloalkyl,and their use as endoparasiticides.
    Type: Grant
    Filed: August 10, 1994
    Date of Patent: December 17, 1996
    Assignee: Bayer Aktiengesellschaft
    Inventors: Peter Jeschke, Werner Lindner, Achim Harder, Norbert Mencke, Axel Haberkorn
  • Patent number: 5571793
    Abstract: The present invention relates to the use of open-chain tetradepsipepties of the formula ##STR1## in a method for combatting endoparasites in humans and animals.
    Type: Grant
    Filed: December 2, 1994
    Date of Patent: November 5, 1996
    Assignee: Bayer Aktiengesellschaft
    Inventors: J urgen Scherkenbeck, Peter Jeschke, Andrew Plant, Achim Harder, Norbert Mencke
  • Patent number: 5529984
    Abstract: This invention relates to a method of combatting endoparasites which comprises administering an endoparasiticidally effective amount of a hexadepsipetide of the formula ##STR1## to a human or animal in need thereof.
    Type: Grant
    Filed: December 2, 1994
    Date of Patent: June 25, 1996
    Assignee: Bayer Aktiengesellschaft
    Inventors: Peter Jeschke, Jurgen Scherkenbeck, Andrew Plant, Achim Harder, Norbert Mencke
  • Patent number: 5525591
    Abstract: The present invention relates to the use of open-chain octadepsipeptides of the general formula (I) ##STR1## which are used for combating endoparsites in medicine and veterinary medicine.
    Type: Grant
    Filed: December 1, 1994
    Date of Patent: June 11, 1996
    Assignee: Bayer Aktiengesellschaft
    Inventors: Jurgen Scherkenbeck, Peter Jeschke, Andrew Plant, Achim Harder, Norbert Mencke
  • Patent number: 5428047
    Abstract: The present invention relates to the use of substituted 1,2,4-oxadiazole derivatives of the general formula I ##STR1## in which R.sup.1 represents hydrogen, alkyl which is optionally substituted by halogen, alkoxy, hydroxyl, amino, alkylamino, dialkylamino, cycloalkylamino as well as cycloalkyl, optionally substituted aryl or hetaryl,R.sup.2 represents hydrogen and alkyl,X represents O, S, SO, SO.sub.2 and N-R.sup.3,R.sup.3 represents hydrogen, alkyl, alkylcarbonyl or halogenoalkylcarbonylR.sup.
    Type: Grant
    Filed: September 21, 1993
    Date of Patent: June 27, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Peter Jeschke, Werner Lindner, Achim Harder, Norbert Mencke
  • Patent number: 5371231
    Abstract: The present invention relates to new substituted 1,2,4-oxadiazole derivatives of the formula (I) and to their stereoisomers ##STR1## in which formula R.sup.4 represents OH, SH, halogenoalkoxy, halogenoalkylthio, halogenoalkylsulphinyl, halogenoalkylsulphonyl, aryloxy, aralkoxy, arylthio, aralkylthio, alkylenedioxy, halogenoalkylenedioxy, amino, alkylamino, dialkylamino, acylamino, carbamoyl, alkylsulphinyl, alkylsulphonyl, arylsuphinyl, arylsulphonyl, sulphonylamino, alkoxycarbonyl, alkylcarbonyl, alkylcarbonyloxy, alkoxyalkyl, alkoxyalkoxy or hydroxyalkoxy, where in the event that at least one of the radicals R.sup.2 or R.sup.3 is other than hydrogen, R.sup.4 additionally represents halogen, alkyl, halogenoalkyl, alkoxy or thioalkyl, where, in the event that R.sup.1 represents optionally substituted C.sub.1-8 -alkyl, R.sup.4 additionally represents alkoxy,processes for their preparation, and their use as endoparasiticides.
    Type: Grant
    Filed: May 5, 1993
    Date of Patent: December 6, 1994
    Assignee: Bayer Aktiengesellschaft
    Inventors: Peter Jeschke, Werner Lindner, Achim Harder, Norbert Mencke, Axel Haberkorn
  • Patent number: 5236939
    Abstract: Substituted 1,3,4 -oxa- diazolinones of the formula (I) ##STR1## in which X represents O andY represents O or S,are disclosed as useful to combat endoparasites.
    Type: Grant
    Filed: October 17, 1991
    Date of Patent: August 17, 1993
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gerhard Bonse, Nikolaus Muller, Achim Harder
  • Patent number: 5201936
    Abstract: Novel substituted thieno[3,2-b]pyran-5,7-diones of the general formula (I) ##STR1## Processes for their preparation and their use as herbicides and as plant growth regulators and novel intermediates of the formula (VI) ##STR2## (in which R.sup.1, R.sup.2, X, Y and Z have the meaning given in the description).
    Type: Grant
    Filed: October 15, 1991
    Date of Patent: April 13, 1993
    Assignee: Bayer Aktiengesellschaft
    Inventors: Heinz-Jurgen Bertram, Klaus Lurssen, Hans-Joachim Santel, Robert R. Schmidt, Andrew Plant, Bernd-Wieland Kruger, Achim Harder, Norbert Mencke
  • Patent number: 5118680
    Abstract: A method of combating endoparasites in humans and animals which comprises administering to such humans and animals an endoparasiticidally effective amount of a 3-hydroxybenzothiophene of the formula ##STR1## in which X represents .dbd.CH-- or .dbd.N--,Y represents .dbd.O or .dbd.NH,R.sup.1 represents one or more identical or different radicals from the group consisting of hydrogen, alkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy, halogenoalkylthio, alkylenedioxy, halogenoalkylenedioxy, halogen, CN, NO.sub.2, NH.sub.2, alkylamino, dialkylamino, alkylcarbonyl, carbalkoxy, alkylsulphonyl, arylsulphonyl, sulphamoyl, alkylsulphamoyl, dialkylsulphamoyl, aryl, aryloxy and arylthio, which, in turn, may again be substituted,R.sup.2 represents optionally substituted alkoxy, cycloalkoxy or the radical --NR.sup.3 R.sup.4,R.sup.3 represents hydrogen or alkyl,R.sup.4 represents an alkyl or carbocyclic or heterocyclic armoatic radical or the radical --COOR.sup.5,R.sup.3 and R.sup.
    Type: Grant
    Filed: June 20, 1991
    Date of Patent: June 2, 1992
    Assignee: Bayer Aktiengesellschaft
    Inventors: Nikolaus Muller, Werner Hallenbach, Achim Harder, Werner Lindner
  • Patent number: 5095024
    Abstract: Substituted 1,3,4-thiadiazolinones of the formula (I), ##STR1## in which X represents O or S,R.sup.1 represents hydrogen, alkyl, alkoxy, alkylthio, halogen, halogenoalkyl, halogenoalkoxy or halogenoalkylthio,R.sup.2 represents one or more identical or different radicals from the series comprising hydrogen, alkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy, halogenoalkylthio, alkylenedioxy, halogenoalkylenedioxy, halogen, CN, NO.sub.2, NH.sub.2, alkylamino, dialkylamino, alkylcarbonyl, carbalkoxy, alkylsulphonyl, arylsulphonyl, sulphamoyl, alkylsulphamoyl, dialkylsulphamoyl, aryl, aryloxy and arylthio, each of which can, in turn, be substituted as well, andR.sup.3 represents alkyl, alkenyl or alkynyl, each of which can optionally be substituted,with the exception of the compound 5-methylmercapto-3-phenyl-1,3,4-thiadiazol-2-(3H)-one, are disclosed as being useful to combat endoparasites. Compositions containing these compounds, process for preparing them, and novel intermediates are also disclosed.
    Type: Grant
    Filed: September 13, 1990
    Date of Patent: March 10, 1992
    Assignee: Bayer Aktiengesellschaft
    Inventors: Nikolaus Muller, Gerhard Bonse, Werner Lindner, Achim Harder
  • Patent number: 5095032
    Abstract: Parasiticidal new substituted thienopyranones of the formula ##STR1## in which X represents O or S,R.sup.1 and R.sup.2 independently of one another represent hydrogen, halogen, CN, NO.sub.2, alkyl, aralkyl, aryl, alkylcarbonyl or alkoxycarbonyl, or, together with the adjacent C atoms, form a carbocyclic ring which is optionally interrupted by heteroatoms,R.sup.3 represents optionally substituted alkyl or phenyl,R.sup.4 represents hydrogen or alkyl,R.sup.3 and R.sup.4, together with the adjacent nitrogen atom, represent a heterocyclic 5- or 6-membered ring.Some of the intermediates for making them are also new.
    Type: Grant
    Filed: July 19, 1990
    Date of Patent: March 10, 1992
    Assignee: Bayer Aktiengesellschaft
    Inventors: Heinz-Jurgen Bertram, Nikolaus Muller, Achim Harder