Patents by Inventor Achim Knappik
Achim Knappik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240067753Abstract: The present invention provides antibodies and fragments thereof that specifically detect the complex of a specific cognate antigen-binding moiety, in particular antibodies, and its antigen. The antibodies of the present disclosure do not bind either said cognate antigen binding moiety or said antigen alone and this can be used e.g. to directly detect antigen-bound antigen-binding moieties. Further disclosed are methods for production and use of said antibodies and antibody fragments.Type: ApplicationFiled: March 30, 2023Publication date: February 29, 2024Inventors: Stefan HAERTLE, Christian FRISCH, Achim KNAPPIK
-
Publication number: 20200339703Abstract: The present invention provides antibodies and fragments thereof that specifically detect the complex of a specific cognate antigen-binding moiety, in particular antibodies, and its antigen. The antibodies of the present disclosure do not bind either said cognate antigen binding moiety or said antigen alone and this can be used e.g. to directly detect antigen-bound antigen-binding moieties. Further disclosed are methods for production and use of said antibodies and antibody fragments.Type: ApplicationFiled: July 10, 2020Publication date: October 29, 2020Inventors: Stefan HAERTLE, Christian FRISCH, Achim KNAPPIK
-
Patent number: 10774154Abstract: The present invention provides antibodies and fragments thereof that specifically detect the complex of a specific cognate antigen-binding moiety, in particular antibodies, and its antigen. The antibodies of the present disclosure do not bind either said cognate antigen binding moiety or said antigen alone and this can be used e.g. to directly detect antigen-bound antigen-binding moieties. Further disclosed are methods for production and use of said antibodies and antibody fragments.Type: GrantFiled: December 19, 2017Date of Patent: September 15, 2020Assignee: MORPHOSYS AGInventors: Stefan Haertle, Christian Frisch, Achim Knappik
-
Publication number: 20190248922Abstract: Affinity ligands useful for mild elution affinity chromatography, including affinity ligands specific for immunoglobulins M, A, and E, are disclosed as are method of identifying and using such affinity ligands.Type: ApplicationFiled: April 2, 2019Publication date: August 15, 2019Inventors: Achim Knappik, Stefan Paschen
-
Patent number: 10294306Abstract: Affinity ligands useful for mild elution affinity chromatography, including affinity ligands specific for immunoglobulins M, A, and E, are disclosed as are method of identifying and using such affinity ligands.Type: GrantFiled: May 27, 2016Date of Patent: May 21, 2019Assignee: Bio-Rad Laboratories, Inc.Inventors: Achim Knappik, Stefan Paschen
-
Publication number: 20180134807Abstract: The present invention provides antibodies and fragments thereof that specifically detect the complex of a specific cognate antigen-binding moiety, in particular antibodies, and its antigen. The antibodies of the present disclosure do not bind either said cognate antigen binding moiety or said antigen alone and this can be used e.g. to directly detect antigen-bound antigen-binding moieties. Further disclosed are methods for production and use of said antibodies and antibody fragments.Type: ApplicationFiled: December 19, 2017Publication date: May 17, 2018Inventors: Stefan HAERTLE, Christian FRISCH, Achim KNAPPIK
-
Publication number: 20160347826Abstract: Affinity ligands useful for mild elution affinity chromatography, including affinity ligands specific for immunoglobulins M, A, and E, are disclosed as are method of identifying and using such affinity ligands.Type: ApplicationFiled: May 27, 2016Publication date: December 1, 2016Inventors: Achim Knappik, Stefan Paschen
-
Patent number: 9133500Abstract: The present invention discloses novel screening strategies for the identification of binders that target the active site of enzymatic antigens. The present invention also discloses antigen-binding moieties which bind to the NS2B-NS3 Proteinase of West Nile Virus, in particular binders which bind to the active site, thereby inhibiting the enzymatic activity of the proteinase. The antigen-binding moieties of the present invention have numerous therapeutic and diagnostic applications.Type: GrantFiled: August 6, 2010Date of Patent: September 15, 2015Assignee: MorphoSys A6Inventors: Christian Frisch, Achim Knappik, Alex Y. Strongin, Sergey A. Shiryaev
-
Publication number: 20150197579Abstract: The present invention provides antibodies and fragments thereof that specifically detect the complex of a specific cognate antigen-binding moiety, in particular antibodies, and its antigen. The antibodies of the present disclosure do not bind either said cognate antigen binding moiety or said antigen alone and thus can be used e.g. to directly detect antigen-bound antigen-binding moieties. Further disclosed are methods for use of said antibodies and antibody fragments.Type: ApplicationFiled: August 8, 2013Publication date: July 16, 2015Inventors: Haertle Stefan, Christian Frisch, Achim Knappik
-
Patent number: 8513164Abstract: The present invention relates to a method of identifying one or more genes encoding one or more proteins having an optimized property. In particular, the method comprises expressing a collection of genes and screening for a desired property, identifying a plurality of genes having the desired property, and replacing one or more one or more sub-sequences of each of said genes with a different, compatible genetic sub-sequence, and screening again in order to identify genes encoding proteins having an optimized property.Type: GrantFiled: December 21, 2006Date of Patent: August 20, 2013Assignee: MorphoSys AGInventors: Achim Knappik, Peter Pack, Liming Ge, Simon Moroney, Andreas Plückthun
-
Publication number: 20120178909Abstract: The present invention discloses novel screening strategies for the identification of binders that target the active site of enzymatic antigens. The present invention also discloses antigen-binding moieties which bind to the NS2B-NS3 Proteinase of West Nile Virus, in particular binders which bind to the active site, thereby inhibiting the enzymatic activity of the proteinase. The antigen-binding moieties of the present invention have numerous therapeutic and diagnostic applications.Type: ApplicationFiled: August 6, 2010Publication date: July 12, 2012Applicant: MORPHOSYS AGInventors: Christian Frisch, Achim Knappik, Alex Y. Strongin, Sergey A. Shiryaev
-
Publication number: 20080026948Abstract: The present invention relates to synthetic DNA sequence which encode one or more collections of homologous proteins(poly)peptides, and methods for generating and applying libraries of these DNA sequences. In particular, the invention relates to the preparation of a library of human-derived antibody genes by the use of synthetic consensus sequences which cover the structural repertoire of antibodies encoded in the human genome. Furthermore, the invention relates to the use of a single consensus antibody gene as a universal framework for highly diverse antibody libraries.Type: ApplicationFiled: December 21, 2006Publication date: January 31, 2008Applicant: MORPHOSYS AGInventors: Achim Knappik, Peter Pack, Liming Ge, Simon Moroney, Andreas Pluckthun
-
Patent number: 7264963Abstract: The present invention relates to synthetic DNA sequences which encode one or more collections of homologous proteins/(poly)peptides, and methods for generating and applying libraries of these DNA sequences. In particular, the invention relates to the preparation of a library of human-derived antibody genes by the use of synthetic consensus sequences which cover the structural repertoire of antibodies encoded in the human genome. Furthermore, the invention relates to the use of a single consensus antibody gene as a universal framework for highly diverse antibody libraries.Type: GrantFiled: January 24, 2000Date of Patent: September 4, 2007Assignee: Morphosys AGInventors: Achim Knappik, Peter Pack, Liming Ge, Simon Moroney, Andreas Plückthun
-
Patent number: 6706484Abstract: The present invention relates to synthetic DNA sequences which encode one or more collections of homologous proteins/(poly)peptides, and methods for generating and applying libraries of these DNA sequences. In particular, the invention relates to the preparation of a library of human-derived antibody genes by the use of synthetic consensus sequences which cover the structural repertoire of antibodies encoded in the human genome. Furthermore, the invention relates to the use of a single consensus antibody gene as a universal framework for highly diverse antibody libraries.Type: GrantFiled: January 24, 2000Date of Patent: March 16, 2004Assignee: Morphosys AGInventors: Achim Knappik, Peter Pack, Liming Ge, Simon Moroney, Andreas Plückthun
-
Patent number: 6696248Abstract: The present invention relates to synthetic DNA sequences which encode one or more collections of homologous proteins/(poly)peptides, and methods for generating and applying libraries of these DNA sequences. In particular, the invention relates to the preparation of a library of human-derived antibody genes by the use of synthetic consensus sequences which cover the structural repertoire of antibodies encoded in the human genome. Furthermore, the invention relates to the use of a single consensus antibody gene as a universal framework for highly diverse antibody libraries.Type: GrantFiled: January 24, 2000Date of Patent: February 24, 2004Assignee: Morphosys AGInventors: Achim Knappik, Peter Pack, Liming Ge, Simon Moroney, Andreas Plückthun
-
Patent number: 6300064Abstract: The present invention relates to synthetic DNA sequences which encode one or more collections of homologous proteins/(poly)peptides, and methods for generating and applying libraries of these DNA sequences. In particular, the invention relates to the preparation of a library of human-derived antibody genes by the use of synthetic consensus sequences which cover the structural repertoire of antibodies encoded in the human genome. Furthermore, the invention relates to the use of a single consensus antibody gene as a universal framework for highly diverse antibody libraries.Type: GrantFiled: February 18, 1998Date of Patent: October 9, 2001Assignee: Morphosys AGInventors: Achim Knappik, Peter Pack, Liming Ge, Simon Moroney, Andreas Plückthun