Patents by Inventor Achim Krotz

Achim Krotz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chloral-free DCA in oligonucleotide synthesis
    Patent number: 7759480
    Abstract: A process of manufacturing oligonucleotides includes a 5?-deblocking step in which the 5-blocking group is removed with dichloroacetic acid that is essentially free of chloral. The process is useful for making oligonucleotides that are substantially free of chloral adducts.
    Type: Grant
    Filed: January 29, 2007
    Date of Patent: July 20, 2010
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Achim Krotz, Daniel C. Capaldi, Hans-Joachim Josef Gaus, Brett Turney
  • PROCESS FOR THE SYNTHESIS OF OLIGOMERIC COMPOUNDS
    Publication number: 20070265435
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Application
    Filed: April 5, 2007
    Publication date: November 15, 2007
    Inventors: Vasulinga Ravikumar, Muthiah Manoharan, Daniel Capaldi, Achim Krotz, Douglas Cole, Andrei Guzaev
  • Oligonucleotide synthesis with alternative solvents
    Patent number: 7276599
    Abstract: The invention provides for methods of manufacturing an oligonucleotide comprising a pentavalent phosphate triester. In particular, the method comprises providing a 5? blocked-nucleoside, deblocking the 5? blocked-nucleoside to form a 5? OH-nucleoside, coupling the 5? OH-nucleoside with a phosphoramidite to form and oligonucleotide comprising a trivalent phosphite triester; and oxidizing the oligonucleotide comprising a trivalent phosphite triester to the oligonucleotide comprising a pentavalent phosphate triester. In some embodiments, the wash between any of the steps above is with at least one solvent wash comprising a toluene.
    Type: Grant
    Filed: June 2, 2004
    Date of Patent: October 2, 2007
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Max N. Moore, Mark Andrade, Recaldo Carty, Anthony Scozzari, Achim Krotz
  • Process for the synthesis of oligomeric compounds
    Patent number: 7227016
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Grant
    Filed: December 28, 2004
    Date of Patent: June 5, 2007
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Vasulinga T. Ravikumar, Muthiah Manoharan, Daniel C. Capaldi, Achim Krotz, Douglas L. Cole, Andrei Guzaev
  • CHLORAL-FREE DCA IN OLIGONUCLEOTIDE SYNTHESIS
    Publication number: 20070123703
    Abstract: A process of manufacturing oligonucleotides includes a 5?-deblocking step in which the 5-blocking group is removed with dichloroacetic acid that is essentially free of chloral. The process is useful for making oligonucleotides that are substantially free of chloral adducts.
    Type: Application
    Filed: January 29, 2007
    Publication date: May 31, 2007
    Applicant: Isis Pharmaceuticals, Inc.
    Inventors: Achim Krotz, Daniel Capaldi, Hans Gaus, Brett Turney
  • Process for the synthesis of oligomeric compounds
    Patent number: 7199236
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Grant
    Filed: September 14, 2004
    Date of Patent: April 3, 2007
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Vasulinga T. Ravikumar, Muthiah Manoharan, Daniel C. Capaldi, Achim Krotz, Douglas L. Cole, Andrei Guzaev
  • Process for the synthesis of oligomeric compounds
    Patent number: 7186822
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Grant
    Filed: December 28, 2004
    Date of Patent: March 6, 2007
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Vasulinga Ravikumar, Muthiah Manoharan, Daniel C. Capaldi, Achim Krotz, Douglas L. Cole, Andrei P. Guzaev
  • Chloral-free DCA in oligonucleotide synthesis
    Patent number: 7169916
    Abstract: A process of manufacturing oligonucleotides includes a 5?-deblocking step in which the 5-blocking group is removed with dichloroacetic acid that is essentially free of chloral. The process is useful for making oligonucleotides that are substantially free of chloral adducts.
    Type: Grant
    Filed: March 31, 2003
    Date of Patent: January 30, 2007
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Achim Krotz, Daniel Capaldi, Hans Gaus, Brett Turney
  • Process for the synthesis of oligomeric compounds
    Patent number: 7041816
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Grant
    Filed: January 20, 2004
    Date of Patent: May 9, 2006
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Vasulinga T. Ravikumar, Muthiah Manoharan, Daniel C. Capaldi, Achim Krotz, Douglas L. Cole, Andrei Guzaev
  • Enhancement of the stability of oligonucleotides comprising phosphorothioate linkages by addition of water-soluble antioxidants
    Publication number: 20050208528
    Abstract: Compositions and methods for inhibition of desulfurization in oligonucleotides comprising one or more phosphorothioate linkages. Antioxidants which partition into the aqueous phase of bi-phasic or multi-phasic topical pharmaceutical formulations inhibit desulfurization of phosphorothioate oligonucleotides, resulting in enhanced oligonucleotide stability.
    Type: Application
    Filed: November 24, 2004
    Publication date: September 22, 2005
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: Achim Krotz, Rahul Mehta
  • Process for the synthesis of oligomeric compounds
    Publication number: 20050182251
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Application
    Filed: December 28, 2004
    Publication date: August 18, 2005
    Inventors: Vasulinga Ravikumar, Muthiah Manoharan, Daniel Capaldi, Achim Krotz, Douglas Cole, Andrei Guzaev
  • Process for the synthesis of oligomeric compounds
    Publication number: 20050137391
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Application
    Filed: September 14, 2004
    Publication date: June 23, 2005
    Inventors: Vasulinga Ravikumar, Muthiah Manoharan, Daniel Capaldi, Achim Krotz, Douglas Cole, Andrei Guzaev
  • Process for the synthesis of oligomeric compounds
    Publication number: 20050137390
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Application
    Filed: December 28, 2004
    Publication date: June 23, 2005
    Inventors: Vasulinga Ravikumar, Muthiah Manoharan, Daniel Capaldi, Achim Krotz, Douglas Cole, Andrei Guzaev
  • Chloral-free DCA in oligonucleotide synthesis
    Publication number: 20050075490
    Abstract: A process of manufacturing oligonucleotides includes a 5?-deblocking step in which the 5-blocking group is removed with dichloroacetic acid that is essentially free of chloral. The process is useful for making oligonucleotides that are substantially free of chloral adducts.
    Type: Application
    Filed: March 31, 2003
    Publication date: April 7, 2005
    Inventors: Achim Krotz, Daniel Capaldi, Hans Gaus, Brett Turney
  • Process for the synthesis of oligomeric compounds
    Patent number: 6858715
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Grant
    Filed: August 30, 2002
    Date of Patent: February 22, 2005
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Vasulinga T. Ravikumar, Muthiah Manoharan, Daniel C. Capaldi, Achim Krotz, Douglas L. Cole, Andrei Guzaev
  • Oligonucleotide synthesis with alternative solvents
    Publication number: 20050026192
    Abstract: The invention provides for methods of manufacturing an oligonucleotide comprising a pentavalent phosphate triester. In particular, the method comprises providing a 5? blocked-nucleoside, deblocking the 5? blocked-nucleoside to form a 5? OH-nucleoside, coupling the 5? OH-nucleoside with a phosphoramidite to form and oligonucleotide comprising a trivalent phosphite triester; and oxidizing the oligonucleotide comprising a trivalent phosphite triester to the oligonucleotide comprising a pentavalent phosphate triester. In some embodiments, the wash between any of the steps above is with at least one solvent wash comprising a toluene.
    Type: Application
    Filed: June 2, 2004
    Publication date: February 3, 2005
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: Max Moore, Mark Andrade, Recaldo Carty, Anthony Scozzari, Achim Krotz
  • Process for the synthesis of oligomeric compounds
    Publication number: 20040219577
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Application
    Filed: January 20, 2004
    Publication date: November 4, 2004
    Inventors: Vasulinga T. Ravikumar, Muthiah Manoharan, Daniel C. Capaldi, Achim Krotz, Douglas L. Cole, Andrei Guzaev
  • Process for the synthesis of oligomeric compounds
    Publication number: 20030088088
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Application
    Filed: August 30, 2002
    Publication date: May 8, 2003
    Inventors: Vasulinga T. Ravikumar, Muthiah Manoharan, Daniel C. Capaldi, Achim Krotz, Douglas L. Cole, Andrei Guzaev
  • Process for the synthesis of oligomeric compounds
    Patent number: 6465628
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Grant
    Filed: April 9, 1999
    Date of Patent: October 15, 2002
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Vasulinga T. Ravikumar, Muthiah Manoharan, Daniel C. Capaldi, Achim Krotz, Douglas L. Cole, Andrei Guzaev