Patents by Inventor Achim Lass

Achim Lass has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for treatment of cachexia by administering inhibitors of adipose triglyceride lipase expression or activity
    Patent number: 8993509
    Abstract: The present invention relates to agents, and methods for identifying compounds, which agents and compounds are effective in the treatment, and more particularly, that inhibit cachexia, and its associated or related disorders and conditions. In addition, the invention relates to compositions and methods for the use thereof in treating conditions that are characterized by cachexia, and its associated or related disorders and conditions and/or cachexia, and its associated or related disorders and conditions, such as for example, cancer cachexia and cachexia associated with AIDS, autoimmune disorders, drug addiction, alcoholism, chronic inflammatory disorders, cirrhosis of the liver, anorexia and neurodegenerative disease. In particular, the diagnostic marker and drug target of the invention is the ATGL Lipase, which can be inhibited by e.g. siRNAs and compounds with any of the following structures (I).
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: March 31, 2015
    Inventors: Robert Zimmerman, Rudolf Zechner, Günther Haemmerle, Gerald Höfler, Suman Das, Achim Lass
  • MODULATION OF ADIPOSE TRIGLYCERIDE LIPASE FOR PREVENTION AND TREATMENT OF CACHEXIA, LOSS OF WEIGHT AND MUSCLE ATROPHY AND METHODS OF SCREENING THEREFOR
    Publication number: 20120230943
    Abstract: The present invention relates to agents, and methods for identifying compounds, which agents and compounds are effective in the treatment, and more particularly, that inhibit cachexia, and its associated or related disorders and conditions. In addition, the invention relates to compositions and methods for the use thereof in treating conditions that are characterized by cachexia, and its associated or related disorders and conditions and/or cachexia, and its associated or related disorders and conditions, such as for example, cancer cachexia and cachexia associated with AIDS, autoimmune disorders, drug addiction, alcoholism, chronic inflammatory disorders, cirrhosis of the liver, anorexia and neurodegenerative disease. In particular, the diagnostic marker and drug target of the invention is the ATGL Lipase, which can be inhibited by e.g. siRNAs and compounds with any of the following structures (I).
    Type: Application
    Filed: March 31, 2010
    Publication date: September 13, 2012
    Inventors: Robert Zimmerman, Rudolf Zechner, Günther Haemmerle, Gerald Höfler, Suman Das, Achim Lass
  • PHARMACEUTICAL COMPOSITION FOR MODULATING THE ACTIVITY OF A NOVEL TRIGLYCERIDE HYDROLASE
    Publication number: 20120009613
    Abstract: Use of an inhibitor or activator of the triglyceride hydrolyse activity of a protein comprising a polypeptide strand encoded by the DNA sequence according to SEQ No. 1 for the preparation of a pharmaceutical composition for the treatment of medical disorders where it is desirable to modulate the activity of a protein encoded by the DNA sequence according to SEQ No. 1.
    Type: Application
    Filed: June 3, 2011
    Publication date: January 12, 2012
    Applicant: Karl-Franzens-Universitat Graz
    Inventors: Rudolpf ZECHNER, Robert Zimmermann, Juliane G. Strauss, Gunter Hammerle, Achim Lass
  • PHARMACEUTICAL COMPOSITIONS FOR MODULATING THE ACTIVITY OF A NOVEL TRIGLYCERIDE HYDROLASE
    Publication number: 20090018066
    Abstract: Use of an inhibitor or activator of the triglyceride hydrolyse activity of a protein comprising a polypeptide strand encoded by the DNA sequence according to SEQ No. 1 for the preparation of a pharmaceutical composition for the treatment of medical disorders where it is desirable to modulate the activity of a protein encoded by the DNA sequence according to SEQ No. 1.
    Type: Application
    Filed: January 29, 2008
    Publication date: January 15, 2009
    Applicant: KARLFRANZENS-UNIVERSITAT GRAZ
    Inventors: Rudolph Zechner, Robert Zimmermann, Juliane G. Strauss, Gunter Hammerle, Achim Lass