Abstract: A device may generate, based at least on time series data of a quantity of one or more markers present in a blood sample of a subject, a dynamical system model representative of an immune system of the subject, the dynamical system model including one or more functions corresponding to a derivative of the time series data, and the generating of the dynamical system model includes performing a regression to identify, within a library of candidate functions, one or more functions for inclusion in the dynamical system model. A device may determine a steady state solution for the one or more functions included in the dynamical system model. A device may determine, based at least on the steady state solution for the one or more functions included in the dynamical system model, a stability of the immune system of the subject. Related systems and computer program products are also provided.

Abstract: Provided herein are, inter alia, antibodies (e.g. humanized antibodies, monoclonal antibodies, antibody fragments (e.g., scFvs) and antibody compositions (e.g., chimeric antigen receptors, bispecific antibodies), which bind herpesvirus entry mediator (HVEM) with high efficiency and specificity. The antibodies and antibody compositions provided herein include novel light and heavy chain domain CDRs and framework regions and are, inter alia, useful for diagnosing and treating cancer and other HVEM-related diseases.