Patents by Inventor Ada Funaro

Ada Funaro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Epitopes of the human PDGF receptor able to bind human auto-antibodies, antibodies and uses thereof
    Patent number: 9150634
    Abstract: The present invention refers to peptides comprised in the extracellular region of human PDGF receptor (hPDGFR) alpha, their use for detecting auto-antibodies anti-hPDGFR alpha and to a method for the diagnosis or the monitoring control for therapy of SSc. The present invention also refers to antibodies or recombinant or synthetic derivatives thereof able to recognize and bind to the above peptide and to their use in the treatment of SSc.
    Type: Grant
    Filed: July 29, 2011
    Date of Patent: October 6, 2015
    Inventors: Gianluca Moroncini, Ada Funaro, Armando Gabrielli, Vittorio Enrico Avvedimento, Silvia Svegliati Baroni, Mariarosaria Santillo, Roberto Paterno′
  • EPITOPES OF THE HUMAN PDGF RECEPTOR ABLE TO BIND HUMAN AUTO-ANTIBODIES, ANTIBODIES AND USES THEREOF
    Publication number: 20130130268
    Abstract: The present invention refers to peptides comprised in the extracellular region of human PDGF receptor (hPDGFR) alpha, their use for detecting auto-antibodies anti-hPDGFR alpha and to a method for the diagnosis or the monitoring control for therapy of SSc. The present invention also refers to antibodies or recombinant or synthetic derivatives thereof able to recognize and bind to the above peptide and to their use in the treatment of SSc.
    Type: Application
    Filed: July 29, 2011
    Publication date: May 23, 2013
    Inventors: Gianluca Moroncini, Ada Funaro, Armando Gabrielli, Vittorio Enrico Avvedimento, Silvia Svegliati Baroni, Mariarosaria Santillo, Roberto Paterno'
  • Methods for obtaining immortalized antibody secreting cells
    Patent number: 8338172
    Abstract: The present Invention provides novel methods for immortalizing cells that secrete antibodies of one or more specific isotypes. Polyclonal, oligoclonal, and monoclonal populations of cells obtained using the methods of the Invention can be screened on the basis of the functional and/or binding activities of the antibodies they secrete, for example directed to antigens of human or viral origin having medical interest, in cell culture conditions. Using these methods, human B cells that secrete antibodies binding human Cytomegalovirus, Herpes Simplex Virus, or HSP60 protein have been efficiently immortalized with Epstein-Barr virus.
    Type: Grant
    Filed: December 15, 2006
    Date of Patent: December 25, 2012
    Assignee: Ribovax Biotechnologies S.A.
    Inventors: Ada Funaro, Gianni Garotta, Marianne Murphy
  • STIMULATORY AUTO-ANTIBODIES TO THE PDGF RECEPTOR AS PATHOLOGY MARKER AND THERAPEUTIC TARGET
    Publication number: 20120252037
    Abstract: An in vitro method for detecting the presence in a body sample of auto-antibodies for the PDGF receptor suitable for the diagnosis and prognosis of autoimmune diseases, in particular the systemic sclerosis and related diagnostic kits. Use of an inhibitor of ROS and/or Ras-ERK1/2 for the preparation of a medicament for therapeutic treatment of autoimmune diseases or of treating the Graft-Versus-Host-Reaction (GVHR). Pharmaceutical composition comprising an effective amount of an inhibitor of ROS and/or Ras-ERK1/2, and proper diluents, and/or excipients, and/or adjuvants.
    Type: Application
    Filed: September 28, 2011
    Publication date: October 4, 2012
    Inventors: Vittorio Enrico AVVEDIMENTO, Armando GABRIELLI, Mariarosa SANTILLO, Ada FUNARO, Michele LUCHETTI, Silvia SVEGLIATI BARONI
  • Antibodies against human cytomegalovirus (HCMV)
    Patent number: 8202518
    Abstract: The present invention provides novel antibody sequences that bind human cytomegalovirus (hCMV) and neutralize hCMV infection. The novel sequences can be used for the medical management of hCMV infections, in particular for preparing pharmaceutical compositions to be used in the prophylactic or therapeutic treatment of hCMV infections.
    Type: Grant
    Filed: June 30, 2008
    Date of Patent: June 19, 2012
    Assignee: Ribovax Biotechnologies S.A.
    Inventors: Ada Funaro, Giorgio Gribaudo, Santo Landolfo
  • Antibodies against human cytimegalovirus (HCMV)
    Patent number: 8153129
    Abstract: The present invention provides novel antibody sequences that bind human cytomegalovirus (hCMV) and neutralize hCMV infection. The novel sequences can be used for the medical management of hCMV infections, in particular for preparing pharmaceutical compositions to be used in the prophylactic or therapeutic treatment of hCMV infections.
    Type: Grant
    Filed: December 17, 2007
    Date of Patent: April 10, 2012
    Assignee: Ribovax Biotechnologies S.A.
    Inventors: Ada Funaro, Giorgio Gribaudo, Santo Landolfo
  • Antibodies Against Human Cytomegalovirus (HCMV)
    Publication number: 20110171233
    Abstract: The present invention provides novel antibodies sequences that bind human cytomegalovirus (hCMV) and neutralize hCMV infection. The novel sequences can be used for the medical management of hCMV infections, in particular for preparing pharmaceutical compositions to be used in the prophylactic or therapeutic treatment of hCMV infections.
    Type: Application
    Filed: July 31, 2008
    Publication date: July 14, 2011
    Applicant: RIBOVAX BIOTECHNOLOGIES S.A.
    Inventors: Ada Funaro, Giorgio Gribaudo, Santo Landolfo
  • Antibodies Against Human Cytomegalovirus (HCMV)
    Publication number: 20100284916
    Abstract: The present invention provides novel antibody sequences that bind human cytomegalovirus (hCMV) and neutralize hCMV infection. The novel sequences can be used for the medical management of hCMV infections, in particular for preparing pharmaceutical compositions to be used in the prophylactic or therapeutic treatment of hCMV infections.
    Type: Application
    Filed: June 30, 2008
    Publication date: November 11, 2010
    Applicant: RIBOVAX BIOTECHNOLOGIES S.A.
    Inventors: Ada Funaro, Giorgio Gribaudo, Santo Landolfo
  • Antibodies against Human Cytimegalovirus (HCMV)
    Publication number: 20100040602
    Abstract: The present invention provides novel antibody sequences that bind human cytomegalovirus (hCMV) and neutralize hCMV infection. The novel sequences can be used for the medical management of hCMV infections, in particular for preparing pharmaceutical compositions to be used in the prophylactic or therapeutic treatment of hCMV infections.
    Type: Application
    Filed: December 12, 2007
    Publication date: February 18, 2010
    Applicant: RIBOVAX BIOTECHNOLOGIES SA
    Inventors: Ada Funaro, Giorgio Gribaudo, Santo Landolfo
  • Methods for Obtaining Immortalized Antibody Secreting Cells
    Publication number: 20090270268
    Abstract: The present Invention provides novel methods for immortalizing cells that secrete antibodies of one or more specific isotypes. Polyclonal, oligoclonal, and monoclonal populations of cells obtained using the methods of the Invention can be screened on the basis of the functional and/or binding activities of the antibodies they secrete, for example directed to antigens of human or viral origin having medical interest, in cell culture conditions. Using these methods, human B cells that secrete antibodies binding human Cytomegalovirus, Herpes Simplex Virus, or HSP60 protein have been efficiently immortalized with Epstein-Barr virus.
    Type: Application
    Filed: December 15, 2006
    Publication date: October 29, 2009
    Applicant: RIBOVAX BIOTECHNOLOGIES SA
    Inventors: Ada Funaro, Gianni Garotta, Marianne Murphy
  • STIMULATORY AUTO-ANTIBODIES TO THE PDGF RECEPTORS AS PATHOLOGY MARKER AND THERAPEUTIC TARGET
    Publication number: 20090221481
    Abstract: An in vitro method for detecting the presence in a body sample of auto-antibodies for the PDGF receptor suitable for the diagnosis and prognosis of autoimmune diseases, in particular the systemic sclero-is and related diagnostic kits. Use of an inhibitor of ROS and/or Ras-ERK1/2 for the preparation of a medicament for therapeutic treatment of autoimmune diseases or of treating the Graft-Versus-Host-Reaction (GVHR). Pharmaceutical composition comprising an effective amount of an inhibitor of ROS and/or Ras-ERK1/2, and proper diluents, and/or excipients, and/or adjuvants.
    Type: Application
    Filed: July 28, 2006
    Publication date: September 3, 2009
    Inventors: Vittorio Enrico Avvedimento, Armando Gabrielli, Mariarosa Santillo, Ada Funaro, Michele Luchetti, Silvia Svegliati Baroni