Patents by Inventor Adah Almutairi

Adah Almutairi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190321099
    Abstract: A system and method are provided for minimally-invasive selective fat removal from a target area by injecting the area with a solution of photo-absorbing nanoparticles and irradiating the injected area with a beam of near infrared (NIR) light. The NIR emission wavelength excites the nanoparticles to melt fat within the target area so that the liquefied fat can be aspirated from the target area. The nanoparticles may be gold nanorods having aspect ratios selected to produce surface plasmon resonance when irradiated with NIR light around 800 nm.
    Type: Application
    Filed: January 24, 2019
    Publication date: October 24, 2019
    Inventors: Adah ALMUTAIRI, Khalid ALMUTAIRI
  • Patent number: 10370488
    Abstract: PLGA-based polymers include pendant nucleophiles protected with photocleavable protecting groups. Upon deprotection, the polymers degrade rapidly via intramolecular cyclization into small molecules. The polymer may be formulated as a nanoparticle, with an encapsulated payload, which may be an imaging agent, a bioactive agent or a pharmaceutical agent.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: August 6, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Adah Almutairi, Jason Olejniczak, Minnie Chan
  • Patent number: 10220117
    Abstract: The invention provides an in vitro method for producing isolated mammalian primitive retinal stem cells (pRSCs) comprising: (a) culturing isolated embryonic stem cells (ESCs) from a mammal in a cell culture medium that is free of feeder cells, feeder-conditioned medium or serum so as to produce and grow a culture of the isolated ESCs; and (b) contacting the culture of the isolated ESCs so grown with one or more of an inhibitor for Wnt or TGF-?/BMP signaling so as to differentiate the isolated ESCs of (a) into primitive retinal stem cells thereby producing isolated mammalian pRSCs.
    Type: Grant
    Filed: October 9, 2014
    Date of Patent: March 5, 2019
    Assignee: The Regents of the University of California
    Inventors: Kang Zhang, Jiagang Zhao, Adah Almutairi
  • Patent number: 10188461
    Abstract: A system and method are provided for minimally-invasive selective fat removal from a target area by injecting the area with a solution of photo-absorbing nanoparticles and irradiating the injected area with a beam of near infrared (NIR) light. The NIR emission wavelength excites the nanoparticles to melt fat within the target area so that the liquefied fat can be aspirated from the target area. The nanoparticles may be gold nanorods having aspect ratios selected to produce surface plasmon resonance when irradiated with NIR light around 800 nm.
    Type: Grant
    Filed: December 7, 2016
    Date of Patent: January 29, 2019
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, ELUX MEDICAL, INC.
    Inventors: Adah Almutairi, Khalid Almutairi
  • Publication number: 20180079860
    Abstract: PLGA-based polymers include pendant nucleophiles protected with photocleavable protecting groups. Upon deprotection, the polymers degrade rapidly via intramolecular cyclization into small molecules. The polymer may be formulated as a nanoparticle, with an encapsulated payload, which may be an imaging agent, a bioactive agent or a pharmaceutical agent.
    Type: Application
    Filed: April 8, 2016
    Publication date: March 22, 2018
    Inventors: Adah ALMUTAIRI, Jason OLEJNICZAK, Minnie CHAN
  • Patent number: 9724417
    Abstract: Compositions are provided in which dendrimers and/or nanoparticles are synthesized with multi-photon responsive elements and self-immolative oligomers. The compositions may be utilized to selectively deliver Payloads within tissue by irradiating the compositions. The compositions may also be used to amplify sensitivity to irradiation.
    Type: Grant
    Filed: August 8, 2014
    Date of Patent: August 8, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Adah Almutairi, Nadezda Fomina, Jagadis Sankaranarayanan
  • Patent number: 9700620
    Abstract: Near infrared radiation at a wavelength that induces resonance in water is used to remotely activate thermal plasticization of polymeric particles to trigger the release of encapsulated molecules from the particles. Nanocarriers formed from biocompatible hydrophilic polymers may be used to deliver encapsulated molecules to tissue with a reversible transition that allows repeated activations for extended release of the payload.
    Type: Grant
    Filed: July 18, 2016
    Date of Patent: July 11, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Adah Almutairi, Mathieu Lessard-Viger, Wangzhong Sheng
  • Patent number: 9687553
    Abstract: Nanocarriers are synthesized with polymers that respond to lower pH and/or ROS by being degraded. The compositions may be utilized to selectively deliver payloads within patients by responding to lower pH and/or ROS at localities within the patient. The present invention also features methods of synthesizing nanocarriers that are degraded by lower pH and/or ROS.
    Type: Grant
    Filed: May 7, 2014
    Date of Patent: June 27, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Adah Almutairi, Jagadis Sankaranarayanan, Enas Mahmoud, Eric Schopf
  • Publication number: 20170151016
    Abstract: A system and method are provided for minimally-invasive selective fat removal from a target area by injecting the area with a solution of photo-absorbing nanoparticles and irradiating the injected area with a beam of near infrared (NIR) light. The NIR emission wavelength excites the nanoparticles to melt fat within the target area so that the liquefied fat can be aspirated from the target area. The nanoparticles may be gold nanorods having aspect ratios selected to produce surface plasmon resonance when irradiated with NIR light around 800 nm.
    Type: Application
    Filed: December 7, 2016
    Publication date: June 1, 2017
    Inventors: Adah ALMUTAIRI, Khalid ALMUTAIRI
  • Patent number: 9522289
    Abstract: A system and method are provided for minimally-invasive selective fat removal from a target area by injecting the area with a solution of photo-absorbing nanoparticles and irradiating the injected area with a beam of near infrared (NIR) light. The NIR emission wavelength excites the nanoparticles to melt fat within the target area so that the liquefied fat can be aspirated from the target area. The nanoparticles may be gold nanorods having aspect ratios selected to produce surface plasmon resonance when irradiated with NIR light around 800 nm.
    Type: Grant
    Filed: December 23, 2015
    Date of Patent: December 20, 2016
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, eLUX MEDICAL, INC.
    Inventors: Adah Almutairi, Khalid Almutairi
  • Publication number: 20160324966
    Abstract: Near infrared radiation at a wavelength that induces resonance in water is used to remotely activate thermal plasticization of polymeric particles to trigger the release of encapsulated molecules from the particles. Nanocarriers formed from biocompatible hydrophilic polymers may be used to deliver encapsulated molecules to tissue with a reversible transition that allows repeated activations for extended release of the payload.
    Type: Application
    Filed: July 18, 2016
    Publication date: November 10, 2016
    Inventors: Adah ALMUTAIRI, Mathieu LESSARD-VIGER, Wangzhong SHENG
  • Publication number: 20160243285
    Abstract: The invention provides an in vitro method for producing isolated mammalian primitive retinal stem cells (pRSCs) comprising: (a) culturing isolated embryonic stem cells (ESCs) from a mammal in a cell culture medium that is free of feeder cells, feeder-conditioned medium or serum so as to produce and grow a culture of the isolated ESCs; and (b) contacting the culture of the isolated ESCs so grown with one or more of an inhibitor for Wnt or TGF-?/BMP signaling so as to differentiate the isolated ESCs of (a) into primitive retinal stem cells thereby producing isolated mammalian pRSCs.
    Type: Application
    Filed: October 9, 2014
    Publication date: August 25, 2016
    Inventors: Kang Zhang, Jiagang Zhao, Adah Almutairi
  • Publication number: 20160236005
    Abstract: A system and method are provided for minimally-invasive selective fat removal from a target area by injecting the area with a solution of photo-absorbing nanoparticles and irradiating the injected area with a beam of near infrared (NIR) light. The NIR emission wavelength excites the nanoparticles to melt fat within the target area so that the liquefied fat can be aspirated from the target area. The nanoparticles may be gold nanorods having aspect ratios selected to produce surface plasmon resonance when irradiated with NIR light around 800 nm.
    Type: Application
    Filed: December 23, 2015
    Publication date: August 18, 2016
    Inventors: Adah Almutairi, Khalid Almutairi
  • Patent number: 9409322
    Abstract: A method is provided for forming complex tissue using density gradient multilayer polymerization (DGMP) to form strong hydrogels with smooth transitions between layers. The multicompartment hydrogel is formed by co-dissolving a polymer precurser with a constituent in multiple solvent fractions to a create prepolymer solutions with different densities, layering the prepolymer solutions on top of each other from high to low solvent density, and irradiating the prepolymer solutions to form a polymer. The hydrogels may be used as biomimetic matrices.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: August 9, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Adah Almutairi, Yogesh Ner, Jerome Karpiak, Jose Morachis
  • Patent number: 9333264
    Abstract: Disclosed are compositions and synthesis methods that pertain to biocompatible polymeric capsules capable of undergoing backbone degradation and cargo release upon exposure to biologically relevant concentrations of hydrogen peroxide (50-100 ?M of H2O2). In the invention, bio-responsive polyester bearing boronic ester triggers groups that degrade upon exposure to low concentrations of H2O2. The degradation is induced by transformation of a boronic ester to a phenol, which undergoes a quinone methide rearrangement to break down the polyester backbone.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: May 10, 2016
    Assignee: The Regents of the University of California
    Inventors: Adah Almutairi, Caroline De Gracia Lux
  • Patent number: 9333258
    Abstract: A system and method are provided for minimally-invasive removal of fat from a target area by injecting the area with a solution of photo-absorbing nanoparticles and irradiating the injected area with a beam of near infrared (NIR) light. The NIR emission wavelength excites the nanoparticles to melt and liquefy fat within the target area so that the liquefied fat can be aspirated from the target area. The nanoparticles may be gold nanorods having aspect ratios selected to produce surface plasmon resonance when irradiated with NIR light around 800 nm.
    Type: Grant
    Filed: May 8, 2013
    Date of Patent: May 10, 2016
    Assignees: The Regents of the University of California, eLux Medical, Inc.
    Inventors: Adah Almutairi, Khalid Almutairi
  • Patent number: 9333259
    Abstract: A system and method are provided for minimally-invasive selective removal of fat from a target area by injecting the area with a solution of photo-absorbing nanoparticles and irradiating the injected area with a beam of near infrared (NIR) light. The NIR emission wavelength excites the nanoparticles to melt fat within the target area so that the liquefied fat can be aspirated from the target area. The nanoparticles may be gold nanorods having aspect ratios selected to produce surface plasmon resonance when irradiated with NIR light around 800 nm.
    Type: Grant
    Filed: August 20, 2014
    Date of Patent: May 10, 2016
    Assignees: The Regents of the University of California, eLux Medical, Inc.
    Inventors: Adah Almutairi, Khalid Almutairi
  • Publication number: 20150258195
    Abstract: Near infrared radiation at a wavelength that induces resonance in water is used to remotely activate thermal plasticization of polymeric particles to trigger the release of encapsulated molecules from the particles. Nanocarriers formed from biocompatible hydrophilic polymers may be used to deliver encapsulated molecules to tissue with a reversible transition that allows repeated activations for extended release of the payload.
    Type: Application
    Filed: August 28, 2013
    Publication date: September 17, 2015
    Inventors: Adah Almutairi, Mathieu Lessard-Viger, Wangzhong Sheng
  • Publication number: 20150119792
    Abstract: A system and method for delivering a payload to ocular tissue includes a solution of light-degradable nanoparticles encapsulating the payload. The solution may be introduced to the ocular tissue by way of injection or through a contact lens into which the solution is embedded. A light source delivers a beam of light to the ocular tissue at the location where the solution was introduced to initiate breakdown of the particles, releasing the payload. The light source may be a laser, LED, LCD or arc lamp emitting in the ultraviolet light range.
    Type: Application
    Filed: March 8, 2013
    Publication date: April 30, 2015
    Applicant: The Regents of the University of California
    Inventors: Adah Almutairi, Viet Anh Nguyen Huu, Cathryn McFearin, Enas Mahmoud
  • Publication number: 20150079005
    Abstract: Nanocarriers are synthesized with polymers that respond to lower pH and/or ROS by being degraded. The compositions may be utilized to selectively deliver payloads within patients by responding to lower pH and/or ROS at localities within the patient. The present invention also features methods of synthesizing nanocarriers that are degraded by lower pH and/or ROS.
    Type: Application
    Filed: May 7, 2014
    Publication date: March 19, 2015
    Applicant: The Regents of the University of California
    Inventors: Adah Almutairi, Jagadis Sankaranarayanan, Enas Mahmoud, Eric Schopf