Patents by Inventor Adalbert Wagner

Adalbert Wagner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5482957
    Abstract: Azole derivatives, process for their preparation, and their useAzole derivatives of the formula (I) ##STR1## in which A, L, O, R.sup.1, X, Y, Z and q have the meanings given, process for their preparation, pharmaceutical preparations and the use of the compounds are described. Azole derivatives of the formula I where the symbols have for example the following meanings:R.sup.1 is (C.sub.2 -C.sub.10)-alkyl,Z is nitrogen,X and Y are independently of one another CR.sup.2,L is --CH.sub.2 --,q is zero or 1,A is a biphenyl radical which is substituted for example by R.sup.15,R.sup.2 is halogen or hydrogen,R.sup.15 is SO.sub.2 --NH--CO--OR.sup.6 andR.sup.6 is phenyl,are highly active antagonists of angiotensin II receptors.
    Type: Grant
    Filed: April 28, 1994
    Date of Patent: January 9, 1996
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Adalbert Wagner, Heinrich Englert, Heinz-Werner Kleemann, Hermann Gerhards, Bernward Scholkens, Reinhard Becker, Wolfgang Linz, Jean-Paul Vevert, John-Claude Caille
  • Patent number: 5475004
    Abstract: Antagonists for angiotensin II receptors of the AT.sub.1 subtype can be employed for the prophylaxis and combating of coronary heart disease.Furthermore these compounds, such as, for example, azoles of the formula (I) ##STR1## can also be used for the therapy of cognitive and erectile dysfunction.
    Type: Grant
    Filed: June 29, 1993
    Date of Patent: December 12, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Holger Heitsch, Gabriele Wiemer, Adalbert Wagner, Heinz-Werner Kleemann
  • Patent number: 5468764
    Abstract: Angiotensin II receptor antagonists for the treatment of disturbances in cardiac rhythm.Antagonists for angiotensin II receptors of the AT, subtype can be employed for combating cardiac arrhythmias, using azole derivatives.
    Type: Grant
    Filed: June 29, 1993
    Date of Patent: November 21, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Holger Heitsch, Wolfgang Linz, Adalbert Wagner, Heinz-Werner Kleemann
  • Patent number: 5444068
    Abstract: Imidazo-fused iso- and heterocycles, process for their preparation, compositions containing them and their useA compound of the formula ##STR1## in which the symbols have the following meaning: X is a monocyclic radical having 3,4 or 5 ring atoms,R.sup.1,R.sup.2,R.sup.3,R.sup.4,R.sup.12 and R.sup.13 are, for example, an alkyl radical,q is zero or 1,L is, for example, a methylene group andA is the radical, for example, of a heterocycleare highly active as antagonists of angiotensin II receptors. They can be used as pharmaceuticals or diagnostics.
    Type: Grant
    Filed: December 13, 1993
    Date of Patent: August 22, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Holger Heitsch, Adalbert Wagner, Heinz-Werner Kleemann, Hermann Gerhards, Bernward Scholkens
  • Patent number: 5440046
    Abstract: The invention relates to compounds of the formula ##STR1## in which X, Y and Z are identical or different and are N or CR.sup.2, L is an alkylene radical, q is 0 or 1, and A is the radical of a fused heterobicyclic compound. The invention furthermore relates to a process for preparing the said compounds, agents containing these, and the use thereof for angiotensin II receptors.
    Type: Grant
    Filed: May 27, 1994
    Date of Patent: August 8, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Adalbert Wagner, Rainer Henning, Hermann Gerhards, Bernward Scholkens, Jean-Paul Vevert, Jean-Claude Caille
  • Patent number: 5350751
    Abstract: The invention relates to compounds of the formula I ##STR1## in which X, Y and Z are identical or different and are N or CR.sup.2, R.sup.1 and R.sup.2 are as defined in the description, L is an alkylene radical, q is 0 or 1, and A is the radical of a fused heterobicyclic compound. The invention furthermore relates to a process for preparing the said compounds, agents containing these, and the use thereof in the treatment of high blood pressure.
    Type: Grant
    Filed: April 2, 1991
    Date of Patent: September 27, 1994
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Adalbert Wagner, Rainer Henning, Hermann Gerhards, Bernward Scholkens, Jean-Paul Vevert, Jean-Claude Caille
  • Patent number: 5225414
    Abstract: The invention relates to compounds of the formula (I) ##STR1## in which X, Y and Z are identical or different and are N or CR.sup.2, and the other radicals have the meaning defined in the description, a process for the preparation thereof, agents containing these, and the use thereof.
    Type: Grant
    Filed: July 18, 1991
    Date of Patent: July 6, 1993
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Rainer Henning, Adalbert Wagner, Hermann Gerhards, Bernward Scholkens
  • Patent number: 4855286
    Abstract: The invention relates to compounds of the formula ##STR1## in which R.sup.1 is absent or denotes hydrogen, alkyl or acyl, A denotes an acyl radical or an amino acid residue, B denotes an amino acid residue, and R.sup.2, R.sup.3 and R.sup.4 are as defined in the specification, and to their salts, to a process for their preparation, to pharmaceutical products containing them, and to their use as medicaments, and intermediates for the preparation of these compounds.
    Type: Grant
    Filed: July 28, 1987
    Date of Patent: August 8, 1989
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Adalbert Wagner, Heinz-Werner Kleemann, Dieter Ruppert, Bernward Scholkens