Abstract: The present invention relates to a sensor applicator assembly for a continuous glucose monitoring system and provides a sensor applicator assembly for a continuous glucose monitoring system, which is manufactured with a sensor module assembled inside an applicator, thereby minimizing additional work by a user for attaching the sensor module to the body and allowing the sensor module to be attached to the body simply by operating the applicator, and thus can be used more conveniently. A battery is built in the sensor module and a separate transmitter is connected to the sensor module so as to receive power supply from the sensor module and be continuously used semi-permanently, thereby making the assembly economical. The sensor module and the applicator are used as disposables, thereby allowing accurate and safe use and convenient maintenance.

Abstract: A severity estimation system for one or more occupants located in an interior cabin of a vehicle involved in a vehicle-related incident includes one or more microphones located within the interior cabin of the vehicle that capture audio-based inputs, an occupant monitoring system (OMS) that collects scene recognition inputs indicative of a status of the occupants, a restraint system that collects a plurality of restraint-based inputs indicative of one or more restraint-based mechanisms associated with an occupant of the vehicle being activated during the vehicle-related incident, a motion-based indicator system that collect the plurality of motion-based inputs indicative of the motion of the vehicle during the vehicle-related incident, and one or more controllers. The one or more controllers fuse together the audio-based indicator, the OMS indicator, the restraint-based indicator, and the motion-based indicator to determine an incident severity indicator corresponding to the one or more occupants.

Abstract: A mouthpiece for distribution of a liquid in a user's mouth, the mouthpiece comprising an inlet for a tube and an internal channel with at least two outlets, wherein the mouthpiece is configured to be positioned within a superior vestibule of the user's mouth apical to a gingival margin, wherein a thickness of the mouthpiece is less than 1 mm.

Abstract: A medical implant is disclosed. The medical implant includes a body having a first end having a first cross-sectional dimension, a second end having a second cross-sectional dimension, and a tapered portion extending between the first end and the second end. The first cross-sectional dimension is larger than the second cross-sectional dimension. In some embodiments, the body comprises multiple layers.

Abstract: A modular dispenser includes a cartridge configured to hold a plurality of pills. A dispensing base is configured to removably receive the cartridge. The dispensing base includes a funnel with a funnel inlet proximate the opening of the cartridge and a funnel outlet spaced apart from the funnel inlet. A drawer is configured to receive the at least one pill from the funnel outlet in a well and is configured to be slidably received within the dispensing base. A metering flap may be movably positioned between the funnel outlet and the well of the drawer. The metering flap is pivotably coupled to at least one of the funnel and the dispensing base and may be configured to one of a) at least partially block and b) fully block the funnel outlet when the drawer is slidably extended away from the dispensing base.

Abstract: The present disclosure relates to methods for treating, managing, or reducing the severity of one or more neurodegenerative disorders by administration of Candida rugosa lipase (CRL) to a patient in need thereof. The present disclosure also relates to pharmaceutical compositions comprising CRL for treating, managing, or reducing the severity of one or more neurodegenerative disorders. The present disclosure also relates to dietary supplements comprising CRL for improving memory and/or cognitive function in a subject in need thereof.

Abstract: A method is provided for testing for presence of a biological particulate containing an antigen, the method including collecting, in a tube of an apparatus, biological fluid that potentially contains the biological particulate. Using a plunger of the apparatus, the biological fluid is pushed through a filter that is configured to not allow passage of at least some of the biological particulate. Subsequently, while the filter is inside the tube, the presence of the biological particulate is tested for by ascertaining if any of the biological particulate was trapped by the filter. Ascertaining includes applying to the filter a releasing agent solution configured to release an antigen from the biological particulate into the releasing agent solution, and, thereafter, testing the releasing agent solution for the presence of the released antigen. Other embodiments are also described.

Abstract: A sample cartridge for a chemical processing instrument. The sample cartridge comprises a primary reaction vessel configured to accommodate a fluid sample for processing and configured to receive a lid for closing an open top of the primary reaction vessel, and a reagent vessel configured to receive one or more fluid reagents via an open top of the reagent vessel. The reagent vessel is connected to the primary reaction vessel via a primary reagent channel with a primary reagent valve disposed in the primary reagent channel to control fluid flow through the primary reagent channel. The sample cartridge further comprises a primary pneumatic port in fluid communication with the primary reaction vessel and configured to be connected to a pneumatic module to selectively adjust a pressure within the primary reaction vessel when the lid is closed to draw the fluid contents of the reagent vessel into the primary reaction vessel.

Abstract: A microfluidic chip having a micro channel for processing a sample is provided. The micro channel may focus the sample by using focusing fluid and a core stream forming geometry. The core stream forming geometry may include a lateral fluid focusing component and one or more vertical fluid focusing components. A microfluidic chip may include a plurality micro channels operating in parallel on a microfluidic chip.

Abstract: A welding device includes a thin film and an ultrasonic welding machine including an ultrasonic welding head welding a first component and a second component of a product together. The thin film is pressed against the product by the ultrasonic welding head and covers a welding area and a non-welding area of the product. The thin film absorbs a vibration energy located in the non-welding area to prevent the vibration energy from being concentrated in the welding area of the product.

Abstract: A method of controlling a cooling system for a hybrid electric vehicle can include measuring an outside air temperature, determining whether the measured outside air temperature is within a preset low-temperature environment temperature range, determining, in a case where a determination is made that the outside air temperature is within the low-temperature environment temperature range, whether a vehicle state corresponds to a preset heating mode, detecting, in a case where a determination is made that the vehicle state does not correspond to the heating mode, a coolant temperature, and controlling, in a case where a determination is made that the coolant temperature detected by a coolant temperature measurement unit is within a preset target temperature range, opening and closing of a control valve by the controller to selectively perform a coolant flow stop control in a low-temperature environment.

Abstract: The in-vehicle temperature control system of the present disclosure includes a low-temperature coolant circuit and a high-temperature coolant circuit that are capable of exchanging heat through a refrigerant circuit, a low-temperature side heat exchanger provided in the low-temperature coolant circuit, a high-temperature side heat exchanger provided in the high-temperature coolant circuit, and a common heat radiation unit. The in-vehicle temperature control system executes heat radiation suppression control for suppressing exhaust heat from the high-temperature side heat exchanger under a predetermined condition in which cooling in the low-temperature coolant circuit that is performed based on a state of a unit that is cooled by exhaust heat from the low-temperature side heat exchanger is prioritized, based on the state of the unit.

Abstract: It is provided a drive system for an electric bicycle, said drive system comprising: at least one acceleration sensor for providing an acceleration signal that is representative of the acceleration of the electric bicycle, and at least one rotation angle sensor for providing a rotational speed signal that is representative of a rotational speed of a bottom bracket shaft. An electronic control unit provided for controlling a drive motor of the electric bicycle is configured to use the acceleration signal and the rotational speed signal to calculate a torque applied to the bottom bracket shaft by muscle power and to control an assistance power provided by the drive motor on the basis of the calculated torque.

Abstract: A goods storage system includes, among other things, a goods repository with several lifting apparatuses without a drive arranged in storage shafts, wherein each lifting apparatus or a corresponding group of lifting apparatuses include a drive coupling which is designed to apply a drive torque to the lifting apparatus. The drive couplings are accessible from a driving level. The system further includes at least one driverless vehicle with a lifting drive and a drive mating coupling corresponding to the drive couplings of the lifting apparatuses. The drive mating coupling is designed for automatic coupling to one of the drive couplings of the lifting apparatuses when the driverless vehicle is located in couplable proximity to the corresponding drive coupling of the lifting apparatus.

Abstract: Provided are a conveying device and a conveying method capable of improving the position detection accuracy of the holder as compared with the related art. A conveying device 100 includes a coil 107 including a core 105 and a winding 106, a drive unit 108 that supplies a current to the winding 106, a current detection unit 109 that detects the value of the current flowing through the winding 106, and a control unit 110 that calculates the position of a holder 102, in which the control unit 110 calculates the position of the holder 102 based on the current value detected by the current detection unit 109 and the calibration curve obtained in advance, and changes the calibration curve used depending on how the drive voltage is applied by the drive unit 108.

Abstract: Certain aspects of the present disclosure provide brine pre-treatment techniques for direct extraction. A method includes of recovering an element of interest from an aqueous source includes measuring one or more properties of a sample brine extracted from the aqueous source; comparing the measurements of the one or more properties of the sample brine to one or more specified thresholds or ranges; selecting one or more brine pre-treatment stages, of a plurality of configured brine pre-treatment stages, based on the comparison of the one or more properties of the sample brine to the one or more specified thresholds or ranges; and performing the selected one or more brine pre-treatment stages on a process brine extracted from the aqueous source.

Abstract: A system and method for water purification by capture of contaminants in an aqueous mixture is described herein. A system and method for regenerating the capture system is also described. An integrated capture and regeneration system and method is also described including a separation vessel that houses a capture bed and optionally an electrode in electrical contact with the bed with a power source for applying a voltage to the electrode. The aqueous wash liquid may contain a counter ion that binds to the contaminant forming an aggregate contaminant phase that separates from the aqueous wash liquid. The capture bed may be treated with a hydroxide and/or a peroxide, e.g., prior to the counter ion binding the contaminant.

Abstract: This disclosure provides a method for treating a subject afflicted with tumor, which method comprises administering to the subject an antibody or an antigen-binding portion thereof that specifically binds to a Programmed Death-1 (PD-1) receptor and inhibits PD-1 activity. In some embodiments, the tumor is derived from a non-small cell lung cancer (NSCLC). In some embodiments, the tumor expresses Programmed Death Ligand 1. In some embodiments, the subject carries a wild-type STK11 gene.

Abstract: Provided is a molecule comprising an Fc variant. Compared with a molecule comprising an IgG wild-type Fc, the molecule is resistant to the degradation of an immunoglobulin enzyme, and the molecule comprises a human IgG Fc region having a mutation, the mutation being one or more substitutions or deletions at a G237 position (EU numbering), and the substitution preferably being G237A. Further provided are a nucleic acid encoding the molecule, a vector comprising the nucleic acid and a host cell, and a method for preparing the molecule.

Abstract: Method and apparatus for converting waste solid sustainable carbon material to chemical products is described herein. The methods add hydrocarbon derived from fossil sources to gas derived from gasifying waste solid sustainable carbon material to enhance hydrogen availability, and in some cases carbon availability, for production of the chemical products. Carbon dioxide made by the process is at least partially sequestered to yield a chemical manufacturing process with environmental burden substantially less than conventional processes. Use of the hydrocarbon boosts yield of final products.