Abstract: A pharmaceutical preparation for topical application, for the treatment of disorders of the skin, comprising killed mycobacteriae in a suitable vehicle, advantageously in combination with cord factor (CF) and a method for the treatment of disorders of the skin of mammals and especially humans, including premalignant and malignant types of growth and of conditions due to the immunodeficiency of the mammal treated, which comprises disinfecting the affected area of the skin, removing the stratum corneum (horny layer) by repeated application of adhesive tape and applying thereto an ointment as defined above, covering same with an impervious wrap and leaving same in place for 1 to 2 days, and if necessary repeating the treatment at suitable intervals of time.