Abstract: A containment system may include four different widths of panel assemblies, at least four different types of corner assemblies, various types of door assemblies, multiple types of three-way corners or ‘T’ intersections, multiple types of exhaust panel assemblies, multiple types of wall seal assemblies, and other components that form a modular system capable of adapting to various configurations using a minimal number of fasteners, brackets, and/or clamps. Each panel assembly includes a lower assembly, an upper assembly slideably attached to the lower assembly, at least one adjustment mechanism that interfaces with both the lower assembly and the upper assembly, and a sealing member extending between the upper assembly and the lower assembly.