Abstract: The present invention relates to use of biomarkers of dry eye disease, and use of the biomarkers for selection of subjects for treatment and treatment of dry eye disease.

Abstract: The present invention relates to the use of a quinoline compound, or a pharmaceutically acceptable salt thereof, for treatment of a respiratory disease, disorder, or condition selected from chronic cough, pneumonia, and pulmonary sepsis, or an organ L disease, disorder, or condition selected from alcohol induced hepatitis, minimal change disease, and focal segmental glomerulosclerosis.

Abstract: The present invention relates to the use of a quinoline compound, or a pharmaceutically acceptable salt thereof, for treatment of ARDS, viral infections, and other diseases, disorders, and conditions such as those described herein.

Abstract: The present invention relates to pharmaceutical compositions and unit dosage forms comprising a quinoline compound, or a pharmaceutically acceptable salt thereof, which are useful for treatment of a disease, disorder, or condition such as inflammatory diseases, respiratory diseases, organ diseases, viral infections, and sequelae and associated conditions such as acute respiratory distress syndrome.

Abstract: A Composition and Method of Pain Relief, Reduction of Inflammation, Maintenance of Joints, and Soothing Muscle Soreness which alleviates pain and inflammation from muscle strain, spasms, arthritis, and bursitis. The composition and method for alleviation of pain and inflammation generally includes a combination of Lidocaine HCL, camphor, menthol, Bisabolol, glucosamine hydrochloride (glucosamine HCI), chondroitin, and MSM, along with a number of other ingredients. The composition described and claimed herein has been shown to alleviate pain and inflammation from injuries and conditions such as muscle strains, spasms, arthritis, and bursitis. The composition will preferably be incorporated into a topical cream which may be applied to the skin around the affected area to provide not only immediate relief from pain and inflammation, but also long-lasting relief which may last for days or even weeks.

Abstract: A composition and method for alleviation of pain and inflammation which alleviates pain and inflammation from muscle strain, spasms, arthritis, and bursitis. The composition and method for alleviation of pain and inflammation generally includes a combination of lidocaine HCl, hydrocortisone acetate, menthol, glucosamine HCl, and a number of other ingredients. The composition described and claimed herein has been shown to alleviate pain and inflammation from injuries and conditions such as muscle strains, spasms, arthritis, and bursitis. The composition will preferably be incorporated into a topical cream which may be applied to the skin around the affected area to provide not only immediate relief from pain and inflammation, but also long-lasting relief which may last for days or even weeks.

Abstract: The present invention provides phosphorylated and pyrophosphate derivatives of polyols, and structural derivatives of these compounds, and provides pharmaceutical compositions comprising the same. The compounds and compositions disclosed herein have various biological activities, including for example, as allosteric effectors of hemoglobin and/or as kinase inhibitors. The present invention further provides methods for therapy in human or mammalian patients, and methods for synthesis of biologically active compounds and their intermediates.