Patents by Inventor Adam C. Finnefrock

Adam C. Finnefrock has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PD-1 binding proteins
    Patent number: 8168757
    Abstract: The present invention features PD-1 binding proteins, a subset of which inhibits binding of PD-L1 to the PD-1 receptor. These binding proteins can be employed to modulate the immune system through the manipulation of the PD-1 signaling pathway, enhancing host immunity to treat infections and cancer.
    Type: Grant
    Filed: March 3, 2009
    Date of Patent: May 1, 2012
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Adam C. Finnefrock, Tong-Ming Fu, Daniel C. Freed, Danilo R. Casimiro, Fengsheng Li, Aimin Tang
  • PD-1 BINDING PROTEINS
    Publication number: 20110008369
    Abstract: The present invention features PD-1 binding proteins, a subset of which inhibits binding of PD-L1 to the PD-1 receptor. These binding proteins can be employed to modulate the immune system through the manipulation of the PD-1 signaling pathway, enhancing host immunity to treat infections and cancer.
    Type: Application
    Filed: March 3, 2009
    Publication date: January 13, 2011
    Inventors: Adam C. Finnefrock, Tong-Ming Fu, Daniel C. Freed, Danilo R. Casimiro, Fengsheng Li, Aimin Tang
  • Broadly Representative Antigen Sequences and Method for Selection
    Publication number: 20100183651
    Abstract: A novel method for generating vaccine sequences is disclosed herein that preserves contiguous epitope length stretches of amino acids or nucleotides from an input pool of sequences. The method generates continuous, stepwise epitope consensus that together provides for a single globally optimized sequence. The end sequences are designed to maximize overlap between any potential epitope length sequence extract from a natural antigen sequence. The disclosed method, thus, allows one to maximize the number of potential natural epitopes that are mimicked in a resultant vaccine sequence. Various representative HIV vaccine sequences have been generated and are disclosed herein.
    Type: Application
    Filed: March 26, 2008
    Publication date: July 22, 2010
    Inventors: Adam C. Finnefrock, Danilo R. Casimiro, Jon H. Condra, John W. Shiver, Andrew J. Bett