Patents by Inventor Adam Carie

Adam Carie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MANUFACTURE OF TRANS-[TETRACHLOROBIS(1H-INDAZOLE)RUTHENATE (III)] AND COMPOSITIONS THEREOF
    Publication number: 20230357297
    Abstract: The present invention relates to the preparation of compositions comprising sodium trans-[tetrachlorobis(1H-indazole)ruthenate (III)]. Synthesis and formulation preparation is detailed. Impurity profiles are also discussed. Compositions herein are useful for anti-cancer applications.
    Type: Application
    Filed: July 20, 2023
    Publication date: November 9, 2023
    Inventors: Tomas Vojkovsky, Kevin Sill, Adam Carie
  • Manufacture of trans-[tetrachlorobis(1H-indazole)ruthenate (III)] and compositions thereof
    Patent number: 11739111
    Abstract: The present invention relates to the preparation of compositions comprising sodium trans-[tetrachlorobis(1H-indazole)ruthenate (III)]. Synthesis and formulation preparation is detailed. Impurity profiles are also discussed. Compositions herein are useful for anti-cancer applications.
    Type: Grant
    Filed: May 26, 2021
    Date of Patent: August 29, 2023
    Assignee: BOLD THERAPEUTICS, INC.
    Inventors: Tomas Vojkovsky, Kevin Sill, Adam Carie
  • MANUFACTURE OF TRANS-[TETRACHLOROBIS(1H-INDAZOLE)RUTHENATE (III)] AND COMPOSITIONS THEREOF
    Publication number: 20210277040
    Abstract: The present invention relates to the preparation of compositions comprising sodium trans-[tetrachlorobis(1H-indazole)ruthenate (III)]. Synthesis and formulation preparation is detailed. Impurity profiles are also discussed. Compositions herein are useful for anti-cancer applications.
    Type: Application
    Filed: May 26, 2021
    Publication date: September 9, 2021
    Inventors: Tomas Vojkovsky, Kevin Sill, Adam Carie
  • Manufacture of trans-[tetrachlorobis(1H-indazole)ruthenate (III)] and compositions thereof
    Patent number: 11040993
    Abstract: The present invention relates to the preparation of compositions comprising sodium trans-[tetrachlorobis(1H-indazole)ruthenate (III)]. Synthesis and formulation preparation is detailed. Impurity profiles are also discussed. Compositions herein are useful for anti-cancer applications.
    Type: Grant
    Filed: February 4, 2020
    Date of Patent: June 22, 2021
    Assignee: BOLD THERAPEUTICS, INC.
    Inventors: Tomas Vojkovsky, Kevin Sill, Adam Carie
  • SN-38 loaded iron crosslinked micelle and methods thereof
    Patent number: 10857147
    Abstract: The present invention provides SN-38 compositions for treating cancer.
    Type: Grant
    Filed: November 19, 2018
    Date of Patent: December 8, 2020
    Assignee: Intezyne Technologies, Inc.
    Inventors: Kevin N. Sill, Adam Carie
  • Manufacture of trans-[tetrachlorobis(1H-indazole)ruthenate (III)] and compositions thereof
    Patent number: 10611787
    Abstract: The present invention relates to the preparation of compositions comprising sodium trans-[tetrachlorobis(1H-indazole)ruthenate (III)]. Synthesis and formulation preparation is detailed. Impurity profiles are also discussed. Compositions herein are useful for anti-cancer applications.
    Type: Grant
    Filed: May 7, 2018
    Date of Patent: April 7, 2020
    Assignee: Bold Therapeutics, Inc.
    Inventors: Tomas Vojkovsky, Kevin Sill, Adam Carie
  • SN-38 LOADED IRON CROSSLINKED MICELLE AND METHODS THEREOF
    Publication number: 20190321353
    Abstract: The present invention provides SN-38 compositions for treating cancer.
    Type: Application
    Filed: November 19, 2018
    Publication date: October 24, 2019
    Inventors: Kevin N. Sill, Adam Carie
  • SN-38 loaded iron crosslinked micelle and methods thereof
    Patent number: 10143689
    Abstract: The present invention provides SN-38 compositions for treating cancer.
    Type: Grant
    Filed: February 8, 2018
    Date of Patent: December 4, 2018
    Assignee: Interzyne Technologies, Inc.
    Inventors: Kevin N. Sill, Adam Carie
  • MANUFACTURE OF TRANS-[TETRACHLOROBIS(1H-INDAZOLE)RUTHENATE (III)] AND COMPOSITIONS THEREOF
    Publication number: 20180327435
    Abstract: The present invention relates to the preparation of compositions comprising sodium trans-[tetrachlorobis(1H-indazole)ruthenate (III)]. Synthesis and formulation preparation is detailed. Impurity profiles are also discussed. Compositions herein are useful for anti-cancer applications.
    Type: Application
    Filed: May 7, 2018
    Publication date: November 15, 2018
    Inventors: Tomas Vojkovsky, Kevin Sill, Adam Carie
  • SN-38 LOADED IRON CROSSLINKED MICELLE AND METHODS THEREOF
    Publication number: 20180228796
    Abstract: The present invention provides SN-38 compositions for treating cancer.
    Type: Application
    Filed: February 8, 2018
    Publication date: August 16, 2018
    Inventors: Kevin N. Sill, Adam Carie
  • Block copolymers for stable micelles
    Patent number: 10047197
    Abstract: The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same. Compositions herein are useful for drug-delivery applications.
    Type: Grant
    Filed: September 28, 2016
    Date of Patent: August 14, 2018
    Assignee: Intezyne Technologies, Inc.
    Inventors: Kevin Sill, Adam Carie
  • Block copolymers for stable micelles
    Patent number: 9944752
    Abstract: The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same. Compositions herein are useful for drug-delivery applications.
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: April 17, 2018
    Assignee: Intezyne Technologies, Inc.
    Inventors: Kevin Sill, Tomas Vojkovsky, Adam Carie, Joseph Edward Semple, Hooshmand Sheshbaradaran
  • BLOCK COPOLYMERS FOR STABLE MICELLES
    Publication number: 20170253699
    Abstract: The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same. Compositions herein are useful for drug-delivery applications.
    Type: Application
    Filed: September 28, 2016
    Publication date: September 7, 2017
    Inventors: Kevin Sill, Adam Carie
  • Block copolymers for stable micelles
    Patent number: 9499665
    Abstract: The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same. Compositions herein are useful for drug-delivery applications.
    Type: Grant
    Filed: April 23, 2015
    Date of Patent: November 22, 2016
    Assignee: Intezyne Technologies, Inc.
    Inventors: Kevin Sill, Tomas Vojkovsky, Adam Carie
  • BLOCK COPOLYMERS FOR STABLE MICELLES
    Publication number: 20160264732
    Abstract: The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same. Compositions herein are useful for drug-delivery applications.
    Type: Application
    Filed: March 10, 2016
    Publication date: September 15, 2016
    Inventors: Kevin Sill, Tomas Vojkovsky, Adam Carie, Joseph Edward Semple, Hooshmand Sheshbaradaran
  • Block copolymers for stable micelles
    Patent number: 9078930
    Abstract: The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same. Compositions herein are useful for drug-delivery applications.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: July 14, 2015
    Assignee: Intezyne Technologies, Inc.
    Inventors: Kevin Sill, Tomas Vojkovsky, Adam Carie
  • BLOCK COPOLYMERS FOR STABLE MICELLES
    Publication number: 20140113879
    Abstract: The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same. Compositions herein are useful for drug-delivery applications.
    Type: Application
    Filed: September 16, 2013
    Publication date: April 24, 2014
    Applicant: Intezyne Technologies, Inc.
    Inventors: Adam Carie, Kevin Sill
  • COMPOUNDS AND METHODS FOR INDUCING APOPTOSIS IN CANCER CELLS USING A BH3 ALPHA-HELICAL MIMETIC
    Publication number: 20130295185
    Abstract: A novel BH3 ?-helical mimetic, BH3-M6, which binds to Bcl-XL and prevents its binding to fluorescently-labeled Bak-BH3 peptide in vitro with an IC50 value of 734 nM is presented herein. BH3-M6 is a pan-Bcl-2 antagonist that inhibits the binding of Bcl-XL, Bcl-2 and Mcl-1 to multi-domain Bax or Bak, or BH3-only Bim or Bad in a cell-free system and in intact human cancer cells, freeing up pro-apoptotic proteins to induce apoptosis. BH3-M6-induced apoptosis is caspase- and Bax-dependent. Furthermore, human cancer cells with high Bcl-2 or Bcl-XL levels are more sensitive to BH3-M6-induced cell death, suggesting that this compound can overcome drug resistance due to Bcl-2 or Bcl-XL overexpression. The pan-Bcl-2 inhibitor BH3-M6 may be encapsulated in a micelle to provide a more bioavailable therapeutic agent. Specifically, the BH3-M6 compound may be encapsulated within a micelle comprising a multiblock copolymer according to the methods described herein.
    Type: Application
    Filed: July 12, 2013
    Publication date: November 7, 2013
    Inventors: Said M. Sebti, Andrew D. Hamilton, Kevin Sill, Adam Carie
  • BLOCK COPOLYMERS FOR STABLE MICELLES
    Publication number: 20130280306
    Abstract: The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same. Compositions herein are useful for drug-delivery applications.
    Type: Application
    Filed: March 15, 2013
    Publication date: October 24, 2013
    Inventors: Kevin Sill, Tomas Vojkovsky, Adam Carie
  • POLYMER MICELLES CONTAINING SN-38 FOR THE TREATMENT OF CANCER
    Publication number: 20100278932
    Abstract: The present invention provides micelles having SN-38 encapsulated therein.
    Type: Application
    Filed: May 4, 2010
    Publication date: November 4, 2010
    Applicant: Intezyne Technologies, Incorporated
    Inventors: Kevin N. Sill, Habib Skaff, Adam Carie, Jonathan Rios-Doria, Richard Slama, Gregoire Cardoen