Abstract: Systems and methods for treatment of an aortic tear or dissection (such as in the thoracic aortic region) are provided. Some methods disclosed herein include inserting an endoprosthesis near an inlet flap of an aortic tear or dissection, inserting an infusion catheter near the inlet flap of the aortic tear or dissection, positioning said infusion catheter between an outer surface of the endoprosthesis and an aortic wall, expanding the endoprosthesis so that the infusion catheter is in contact with aortic tissue near the inlet flap, infusing a stabilization treatment compound through the infusion catheter, wherein the stabilization treatment compound comprises a contrast media agent, a stabilizing agent, and one or more excipients, and removing the infusion catheter.