Abstract: Method and apparatus for predicting beneficial clinical trials for patients. Embodiments include receiving one or more attributes of a first patient. Embodiments include selecting a potential clinical trial for the first patient, based on the one or more attributes. Embodiments include identifying a cohort of patients that are clinically similar to the first patient, based on the one or more attributes, wherein each patient in the cohort has undergone a respective trial that is either (i) the potential clinical trial, or (ii) a clinically similar clinical trial. Embodiments include determining, for each respective patient in the cohort, a respective outcome of the respective trial. Embodiments include generating a predicted outcome for the first patient, based on the respective outcomes for each patient in the cohort. Embodiments include refraining from recommending the potential clinical trial for the first patient, based on the predicted outcome.

Abstract: Techniques for cognitive analysis of documents are provided. A document corresponding to a clinical trial is received. Criteria are identified for the clinical trial based on processing the electronic document using natural language processing (NLP) techniques, where the criteria specify attributes of individuals that are eligible for the trial. Further, the criteria are analyzed using NLP techniques to determine a respective confidence level for each respective criterion, where the confidence level indicates a degree of certainty that the criterion is applicable to the trial. A knowledge graph is generated based at least in part on the clinical trial, where the confidence level assigned to each criterion is included in the knowledge graph for subsequent use. Finally, one or more therapies in the knowledge graph are selected to be recommended, based on a patient profile and the confidence level assigned to each of the criteria.

Abstract: Techniques for granular analysis of a knowledge graph are provided. A profile comprising a plurality of attributes is received, and a knowledge graph is analyzed to identify a plurality of therapies, based on the plurality of attributes. A document that is relevant to a first therapy of the plurality of therapies is identified, and a criterion stated in the document is determined. Further, an aggregate value is determined for the criterion, based on a plurality of participants associated with the document, wherein the first aggregate value represents attributes of the plurality of participants. A weight is generated for the document, based at least in part on the plurality of attributes and the aggregate value. A score is generated for the first therapy, based at least in part on the weight, and an optimal therapy is determined, from the plurality of therapies, based in part on the score.

Abstract: Techniques for unbounded therapy evaluation are provided. A request to suggest a potential therapy based on a patient profile is received. A plurality of accepted therapies is determined based on the patient profile, where the plurality of accepted therapies is based on stored definitions obtained from one or more subject matter experts. Next, a plurality of therapy components is identified based on the plurality of accepted therapies. A plurality of potential therapies is then identified based on the plurality of therapy components, where none of the plurality of potential therapies are included in the plurality of accepted therapies. A score is generated for a potential therapy of the plurality of potential therapies based on analyzing a knowledge graph, where the score indicates a suitability of the potential therapy for a patient associated with the patient profile. Finally, the potential therapy is provided, along with an indication of the score.

Abstract: Techniques for identifying missing evidence are provided. A plurality of documents, each comprising digitally encoded natural language text data, is received. The plurality of documents is processed to determine a plurality of pair-wise comparisons between a plurality of therapies, where each of the plurality of pair-wise comparisons indicate a relative efficacy of at least one therapy in the plurality of therapies, as compared to at least one other therapy in the plurality of therapies. A knowledge graph is generated based at least in part on aggregating the plurality of pair-wise comparisons, and the knowledge graph is analyzed to identify one or more knowledge gaps within the knowledge graph. Finally, at least an indication of the identified one or more knowledge gaps is output.

Abstract: Cognitive solutions are provided for detection of, and optimization based on, cohorts, arms, and phases in clinical trials. In various embodiments, a first datastore is accessed. The first datastore comprises a clinical trial description. The clinical trial description includes a reference to a cohort, arm, or phase of a clinical study. The clinical trial description is analyzed to identify an entity type. The entity type is a cohort, arm or phase reference. A clinical attribute associated with the entity type is determined within the clinical trial description. A screening criterion associated with the clinical attribute is determined. A second datastore is accessed. The second datastore comprises a medical record of a patient. The medical record is screened against the screening criterion.

Abstract: The present disclosure provides methods and systems for providing a validated drug to an end-user or distributing business. Also provided herein are methods and systems for providing a certificate of analysis for a drug to provide more information to a user.

Abstract: A luminaire including a housing made of thermally conductive material having a top, a bottom and two opposite sides connecting the top to the bottom, each side having plurality of external, vertically spaced, substantially parallel cooling fins that extend longitudinally and project laterally outwardly of the housing, preferably at a shallow downward and outward angle. The housing configuration provides a large surface area per unit of housing length to optimize heat dissipation. A configurable, cartridge-like LED bezel assembly—readily replaceable in the field—is supported on the bottom of the housing. A driver for the LED assembly—also readily replaceable in the field—is located within the housing.

Abstract: Methods and systems are provided for cooling systems for imaging systems. In one embodiment, a manifold assembly for an imaging system comprises: an intake manifold and a return manifold formed by a plurality of unitary sections, the intake manifold and return manifold positioned adjacent to each other and separated by a shared wall; and a plurality of nozzles, with each nozzle of the plurality of nozzles formed by a corresponding section of the plurality of unitary sections. In this way, an assembly difficulty, expense, and/or manufacturing time of the manifold assembly may be decreased.

Abstract: A system, method, and computer program product are provided for allocating processor resources to process compute workloads and graphics workloads substantially simultaneously. The method includes the steps of allocating a plurality of processing units to process tasks associated with a graphics pipeline, receiving a request to allocate at least one processing unit in the plurality of processing units to process tasks associated with a compute pipeline, and reallocating the at least one processing unit to process tasks associated with the compute pipeline.

Abstract: A system and method for managing operating modes within a semiconductor chip for optimal power and performance while meeting a reliability target are described. A semiconductor chip includes a functional unit and a corresponding reliability monitor. The functional unit provides actual usage values to the reliability monitor. The reliability monitor determines expected usage values based on a reliability target and the age of the semiconductor chip. The reliability monitor compares the actual usage values and the expected usage values. The result of this comparison is used to increase or decrease current operational parameters.

Abstract: The present disclosure relates to correcting misalignment of image data within an overlap region in acquired scan data. By way of example, systems and methods for applying a post-reconstruction interpolation are described to correct mis-registration of features within overlap regions in either sequentially acquired axial scans or single scan acquisitions.

Abstract: A positron emission tomography (PET) detector assembly is provided. The PET detector assembly includes a plate having a first side and an opposite second side, the plate being fabricated from a thermally conductive material. The PET detector assembly also includes multiple PET detector units coupled to the first side of the plate. The PET detector assembly further includes a readout electronics section coupled to the second side of the plate, wherein, during operation, the readout electronics section generates heat that is transferred to the plate. The plate comprises a heat pipe disposed within the plate and configured to extract the heat from the plate and to transfer the heat away from the plate.

Abstract: A system and method for managing operating modes within a semiconductor chip for optimal power and performance while meeting a reliability target are described. A semiconductor chip includes a functional unit and a corresponding reliability monitor. The functional unit provides actual usage values to the reliability monitor. The reliability monitor determines expected usage values based on a reliability target and the age of the semiconductor chip. The reliability monitor compares the actual usage values and the expected usage values. The result of this comparison is used to increase or decrease current operational parameters.

Abstract: An apparatus is described herein. The apparatus comprises a first modality unit and a second modality unit. The first modality unit is located within a gantry. The second modality unit within the gantry is moveable along an examination axis to be concentric about with the first modality unit such that a field of view of the first modality unit and a field of view of the second modality unit are centered about a single point of interest.

Abstract: A system and method for efficient management of operating modes within an integrated circuit (IC) for optimal power and performance targets. A semiconductor chip includes processing units each of which operates with respective operating parameters. Temperature sensors are included to measure a temperature of the one or more processing units during operation. A power manager determines a calculated power value independent of thermal conditions and current draw. The power manager reads each of a first thermal design power (TDP) value for the processing units and a second TDP value for a platform housing the semiconductor chip. The power manager determines a ratio of the first TDP value to the second TDP value. Additionally, the power manager determines another ratio of the first TDP value to the calculated power value. Using the measured temperature, the ratios and the calculated power value, the power manager determines a manner to adjust the operating parameters.

Abstract: A patient support system is provided. The patient support system includes a support table including a first end and a second end. The patient support system also includes a patient support coupled to the support table and configured to support a subject during an imaging procedure, wherein a top surface of the patient support is angled relative to a bottom surface of the patient support to position a portion of the subject to be imaged to be orthogonal to an imaging scan plane while the patient support is extended from the second end.

Abstract: A luminaire including a housing made of thermally conductive material having a top, a bottom and two opposite sides connecting the top to the bottom, each side having plurality of external, vertically spaced, substantially parallel cooling fins that extend longitudinally and project laterally outwardly of the housing, preferably at a shallow downward and outward angle. The housing configuration provides a large surface area per unit of housing length to optimize heat dissipation. A configurable, cartridge-like LED bezel assembly—readily replaceable in the field—is supported on the bottom of the housing. A driver for the LED assembly—also readily replaceable in the field—is located within the housing.

Abstract: A system and method for reducing vibration of a cantilevered patient support surface are provided herein. A system includes a spring and roller coupled with the spring. The spring creates an upwards spring bias on the patient support surface. The roller is coupled with the spring via a roller lever arm. A frictional resistance at the roller arm and an upward directed spring bias enables the roller to maintain constant contact with the patient support surface.