Abstract: A luminaire including a housing made of thermally conductive material having a top, a bottom and two opposite sides connecting the top to the bottom, each side having plurality of external, vertically spaced, substantially parallel cooling fins that extend longitudinally and project laterally outwardly of the housing, preferably at a shallow downward and outward angle. The housing configuration provides a large surface area per unit of housing length to optimize heat dissipation. A configurable, cartridge-like LED bezel assembly—readily replaceable in the field—is supported on the bottom of the housing. A driver for the LED assembly—also readily replaceable in the field—is located within the housing.

Abstract: The present invention provides a polypeptide construct comprising a peptide or polypeptide signaling ligand linked to an antibody or antigen binding portion thereof which binds to a cell surface-associated antigen, wherein the ligand comprises at least one amino acid substitution or deletion which reduces its potency on cells lacking expression of said antigen.

Abstract: A system and method for reducing vibration of a cantilevered patient support surface are provided herein. A system includes a spring and roller coupled with the spring. The spring creates an upwards spring bias on the patient support surface. The roller is coupled with the spring via a roller lever arm. A frictional resistance at the roller arm and an upward directed spring bias enables the roller to maintain constant contact with the patient support surface.

Abstract: A positron emission tomography (PET) detector assembly is provided. The PET detector assembly includes a plate having a first side and an opposite second side, the plate being fabricated from a thermally conductive material. The PET detector assembly also includes multiple PET detector units coupled to the first side of the plate. The PET detector assembly further includes a readout electronics section coupled to the second side of the plate, wherein, during operation, the readout electronics section generates heat that is transferred to the plate. The plate comprises a heat pipe disposed within the plate and configured to extract the heat from the plate and to transfer the heat away from the plate.

Abstract: A waste storage device is provided comprising a waste storage compartment for storing waste and a lid. The device further comprises a dispenser for dispensing an agent inside the waste storage device and an actuator arranged to activate the dispenser. A waste cartridge is also provided comprising a relatively rigid upper portion and a relatively flexible lower portion. The relatively flexible lower portion is arranged for storing waste items and the relatively rigid upper portion is arranged to be folded about an axis in a direction substantially towards the relatively flexible lower portion of the waste cartridge.

Abstract: The present invention provides a polypeptide construct comprising a peptide or polypeptide signaling ligand linked to an antibody or antigen binding portion thereof which binds to a cell surface-associated antigen, wherein the ligand comprises at least one amino acid substitution or deletion which reduces its potency on cells lacking expression of said antigen.

Abstract: A system and method for reducing vibration of a cantilevered patient support surface are provided herein. A system includes a spring and roller coupled with the spring. The spring creates an upwards spring bias on the patient support surface. The roller is coupled with the spring via a roller lever arm. A frictional resistance at the roller arm and an upward directed spring bias enables the roller to maintain constant contact with the patient support surface.

Abstract: The disclosure provides TNF-like ligand 1a (TL1a)-binding proteins comprising an antigen binding domain of an antibody which binds specifically to TL1a and inhibits interaction of TL1a and Death Receptor 3 (DR3) and which does not inhibit the interaction of TL1a and Decoy Receptor 3 (DcR3). The disclosure also provides uses of the TL1a-binding proteins.

Abstract: Embodiments relate to systems, apparatuses, and methods for performing transaction signing utilizing asymmetric cryptography and a private ledger. A transaction data is signed by a user device using a private key, and may be utilized in an authorization request message without including a real credential of the user. A transaction verification and accounting module (TVAM) can verify the signed transaction data and can continue processing the transaction.

Abstract: A waste storage device is provided comprising a waste storage compartment for storing waste and a lid. The device further comprises a dispenser for dispensing an agent inside the waste storage device and an actuator arranged to activate the dispenser.

Abstract: An apparatus is described herein. The apparatus comprises a first modality unit and a second modality unit. The first modality unit is located within a gantry. The second modality unit within the gantry is moveable along an examination axis to be concentric about with the first modality unit such that a field of view of the first modality unit and a field of view of the second modality unit are centered about a single point of interest.

Abstract: A system and method for reducing vibration of a cantilevered patient support surface are provided herein. A system includes a spring and roller coupled with the spring. The spring creates an upwards spring bias on the patient support surface. The roller is coupled with the spring via a roller lever arm. A frictional resistance at the roller arm and an upward directed spring bias enables the roller to maintain constant contact with the patient support surface.

Abstract: The present invention provides a fusion polypeptide comprising a first domain and a second domain, wherein the first domain comprises a polypeptide ligand which binds to a cell surface-associated antigen and the second domain comprises aglycosylated interferon ? 2b (IFN?2b) having a sequence of SEQ ID NO: 1 or SEQ ID NO: 2. The aglycosylated IFN?2b further comprises one or more amino acid substitutions or deletions which attenuate the activity of the aglycosylated IFN?2b.

Abstract: Antibodies that specifically bind to CD38, as well as constructs comprising such antibodies fused to attenuated interferon alpha-2B proteins are provided. Anti-CD38-attenuated interferon alpha-2b fusion constructs may be used to inhibit proliferation in cancerous cells that express both CD38 and the receptor for IFN-alpha2b, as well as to induce apoptosis in such cells. Inhibition of proliferation and induction of apoptosis in cancerous cells may serve as the basis for the treatment of the underlying cancer.

Abstract: A system and method for efficient management of operating modes within an integrated circuit (IC) for optimal power and performance targets. A semiconductor chip includes processing units each of which operates with respective operating parameters. Temperature sensors are included to measure a temperature of the one or more processing units during operation. A power manager determines a calculated power value independent of thermal conditions and current draw. The power manager reads each of a first thermal design power (TDP) value for the processing units and a second TDP value for a platform housing the semiconductor chip. The power manager determines a ratio of the first TDP value to the second TDP value. Additionally, the power manager determines another ratio of the first TDP value to the calculated power value. Using the measured temperature, the ratios and the calculated power value, the power manager determines a manner to adjust the operating parameters.

Abstract: A system, method, and computer program product are provided for allocating processor resources to process compute workloads and graphics workloads substantially simultaneously. The method includes the steps of allocating a plurality of processing units to process tasks associated with a graphics pipeline, receiving a request to allocate at least one processing unit in the plurality of processing units to process tasks associated with a compute pipeline, and reallocating the at least one processing unit to process tasks associated with the compute pipeline.

Abstract: One embodiment of the present invention sets forth an architecture for advancing the Z-test operation prior to pixel shading whenever possible. The current rendering state, as maintained by the setup engine, determines whether advancing the Z-test function above the shader engine for “early” Z-testing is possible or whether the Z-test function should be deferred until after shading operations for “late” Z-testing. Data is dynamically routed to each processing engine in the pipeline, so that the appropriate data flow for either early Z or late Z is dynamically constructed, as determined by the current rendering state. The same functional units are utilized in both early Z and late Z configurations.

Abstract: A device and method of the present invention provides application of low-energy acoustic waves to indwelling surfaces of a catheter in order to remove and prevent microbial biofilm formation. The low-energy acoustic waves are generated by an electrically activated piezo element. The device can take the form of a luer connector configured to couple to the hub of the indwelling catheter or can take the form of a catheter insert. The characteristics of the acoustic waves can be varied in order to inhibit bacterial adhesion to the indwelling surfaces of the catheter. Moreover, the characteristics of the acoustic waves must also be in a range so as to not induce bacterial adhesion to the indwelling catheter surfaces.

Abstract: A tool for removing an interchangeable cooking insert from a grill has a handle end and an engagement end. A handle extends from the handle end toward the engagement end. A support arm extends from the handle toward the engagement end. The support arm has a first lateral edge defining a first lifting hook and a second lateral edge defining a second lifting hook. The first lifting hook and second lifting hook are configured to engage a portion of the cooking insert. A support pin extends across the support arm between the first lateral edge and the second lateral edge. A latch member is pivotally coupled to one of the support arm and the handle. The latch member includes a first end selectively engageable with a portion of the cooking insert and a second end extending through the handle for actuation of the latching member by a user.

Abstract: Isolated antibodies or antigen binding portions thereof that bind to CD1d. These antibodies and antigen binding portions thereof have application in treatment of conditions involving NKT cell effector function.