Patents by Inventor Adam Cockrell
Adam Cockrell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11980774Abstract: Devices and related methods for impinging light on tissue to induce one or more biological effects, and more particularly illumination devices and related methods for phototherapeutic light treatments in the presence of vitamins are disclosed. Biological effects may include at least one of inactivating and inhibiting growth of one or more combinations of microorganisms and pathogens, including but not limited to viruses. Phototherapeutic light treatments in the presence of vitamins may involve providing one or more vitamins in the form of a coating or film on a surface of a target tissue and irradiating the target tissue with light. By performing the phototherapeutic light treatment in the presence of vitamins, efficacy of the light treatment may be improved, thereby reducing viral loads and/or reducing doses of light received by the target tissue.Type: GrantFiled: August 5, 2021Date of Patent: May 14, 2024Assignee: KNOW Bio, LLCInventors: Adam Cockrell, Nathan Stasko, Jacob Kocher
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Publication number: 20240075312Abstract: Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an anti-inflammatory effect. Biological effects may include upregulating and downregulating inflammatory immune response molecules within a target tissue. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths.Type: ApplicationFiled: November 14, 2023Publication date: March 7, 2024Inventors: Adam Cockrell, Jacob Kocher, David T. Emerson, Michael John Bergmann, Thomas Matthew Womble, Antony Paul van de Ven, Nathan Stasko, F. Neal Hunter, Rebecca McDonald
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Publication number: 20240024699Abstract: Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and tissues with increased efficacy and reduced cytotoxicity.Type: ApplicationFiled: October 4, 2023Publication date: January 25, 2024Inventors: David T. Emerson, Michael John Bergmann, Thomas Matthew Womble, Antony Paul van de Ven, Nathan Stasko, F. Neal Hunter, Adam Cockrell, Rebecca McDonald, James Michael Lay
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Publication number: 20230302293Abstract: Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an antiinflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and tissues with increased efficacy and reduced cytotoxicity.Type: ApplicationFiled: May 23, 2023Publication date: September 28, 2023Inventors: David T. Emerson, Michael John Bergmann, Thomas Matthew Womble, Antony Paul van de Ven, Nathan Stasko, F. Neal Hunter, Adam Cockrell, Rebecca McDonald, James Michael Lay
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Patent number: 11752359Abstract: Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and tissues with increased efficacy and reduced cytotoxicity.Type: GrantFiled: August 24, 2021Date of Patent: September 12, 2023Assignee: KNOW Bio, LLCInventors: David T. Emerson, Michael John Bergmann, Thomas Matthew Womble, Antony Paul van de Ven, Nathan Stasko, F. Neal Hunter, Adam Cockrell, Rebecca McDonald, James Michael Lay
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Patent number: 11712578Abstract: Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and tissues with increased efficacy and reduced cytotoxicity.Type: GrantFiled: August 24, 2021Date of Patent: August 1, 2023Assignee: KNOW Bio, LLCInventors: David T. Emerson, Michael John Bergmann, Thomas Matthew Womble, Antony Paul van de Ven, Nathan Stasko, F. Neal Hunter, Adam Cockrell, Rebecca McDonald, James Michael Lay
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Patent number: 11684798Abstract: Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and tissues with increased efficacy and reduced cytotoxicity.Type: GrantFiled: August 24, 2021Date of Patent: June 27, 2023Assignee: KNOW Bio, LLCInventors: David T. Emerson, Michael John Bergmann, Thomas Matthew Womble, Antony Paul van de Ven, Nathan Stasko, F. Neal Hunter, Adam Cockrell, Rebecca McDonald, James Michael Lay
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Publication number: 20230043538Abstract: Devices and related methods for impinging light on tissue to induce one or more biological effects, and more particularly illumination devices and related methods for phototherapeutic light treatments in the presence of vitamins are disclosed. Biological effects may include at least one of inactivating and inhibiting growth of one or more combinations of microorganisms and pathogens, including but not limited to viruses. Phototherapeutic light treatments in the presence of vitamins may involve providing one or more vitamins in the form of a coating or film on a surface of a target tissue and irradiating the target tissue with light. By performing the phototherapeutic light treatment in the presence of vitamins, efficacy of the light treatment may be improved, thereby reducing viral loads and/or reducing doses of light received by the target tissue.Type: ApplicationFiled: August 5, 2021Publication date: February 9, 2023Inventors: Adam Cockrell, Nathan Stasko, Jacob Kocher
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Publication number: 20220189342Abstract: Devices and methods for impinging light on tissue to induce one or more biological effects, and more particularly enhanced testing and characterization techniques for phototherapeutic light treatments are disclosed. Such testing and characterization techniques may be particularly useful in the evaluation and development of light-based treatments for various infectious diseases, including multiple variants of SARS-CoV-2. In particular aspects, testing and characterization techniques are related to the direct testing of differentiated tissue models of human airway epithelia that have been exposed to various pathogens. Phototherapeutic light treatments and corresponding treatment protocols for light are also described that not only inactivate SARS-COV-2 variants in cell-free suspensions, but also inhibit SARS-CoV-2 infections at multiple stages of infection in tissue models of human airway epithelia in a variant-agnostic manner.Type: ApplicationFiled: November 1, 2021Publication date: June 16, 2022Inventors: David T. Emerson, Nathan Stasko, Jacob Kocher, Adam Cockrell
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Publication number: 20220023660Abstract: Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and tissues with increased efficacy and reduced cytotoxicity.Type: ApplicationFiled: August 24, 2021Publication date: January 27, 2022Inventors: David T. Emerson, Michael John Bergmann, Thomas Matthew Womble, Antony Paul van de Ven, Nathan Stasko, F. Neal Hunter, Adam Cockrell, Rebecca McDonald
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Publication number: 20210379400Abstract: Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and tissues with increased efficacy and reduced cytotoxicity.Type: ApplicationFiled: August 24, 2021Publication date: December 9, 2021Inventors: David T. Emerson, Michael John Bergmann, Thomas Matthew Womble, Antony Paul van de Ven, Nathan Stasko, F. Neal Hunter, Adam Cockrell, Rebecca McDonald
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Patent number: 11147984Abstract: Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and tissues with increased efficacy and reduced cytotoxicity.Type: GrantFiled: December 10, 2020Date of Patent: October 19, 2021Assignee: KNOW Bio, LLCInventors: David T. Emerson, Michael John Bergmann, Thomas Matthew Womble, Antony Paul van de Ven, Nathan Stasko, F. Neal Hunter, Adam Cockrell, Rebecca McDonald
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Publication number: 20210290971Abstract: Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an anti-inflammatory effect. Biological effects may include upregulating and downregulating inflammatory immune response molecules within a target tissue. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths.Type: ApplicationFiled: February 11, 2021Publication date: September 23, 2021Inventors: Adam Cockrell, Jacob Kocher, David T. Emerson, Michael John Bergmann, Thomas Matthew Womble, Antony Paul van de Ven, Nathan Stasko, F. Neal Hunter, Rebecca McDonald
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Publication number: 20210290974Abstract: Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and tissues with increased efficacy and reduced cytotoxicity.Type: ApplicationFiled: December 10, 2020Publication date: September 23, 2021Inventors: David T. Emerson, Michael John Bergmann, Thomas Matthew Womble, Antony Paul van de Ven, Nathan Stasko, F. Neal Hunter, Adam Cockrell, Rebecca McDonald
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Publication number: 20210290970Abstract: Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and tissues with increased efficacy and reduced cytotoxicity.Type: ApplicationFiled: January 29, 2021Publication date: September 23, 2021Inventors: F. Neal Hunter, Antony Paul van de Ven, Nathan Stasko, David T. Emerson, Michael John Bergmann, Thomas Matthew Womble, Adam Cockrell, Rebecca McDonald
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Publication number: 20210290975Abstract: Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and tissues with increased efficacy and reduced cytotoxicity.Type: ApplicationFiled: January 29, 2021Publication date: September 23, 2021Inventors: F. Neal Hunter, Antony Paul van de Ven, Nathan Stasko, David T. Emerson, Michael John Bergmann, Thomas Matthew Womble, Adam Cockrell, Rebecca McDonald
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Publication number: 20210138259Abstract: Methods and related devices for impinging light on tissue, for example within a body of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, stimulating enzymatic generation of nitric oxide to increase endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores of nitric oxide, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices and methods for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and targeted tissues with increased efficacy and reduced cytotoxicity.Type: ApplicationFiled: January 13, 2021Publication date: May 13, 2021Inventors: Nathan Stasko, David T. Emerson, Adam Cockrell, F. Neal Hunter, Michael John Bergmann, Rebecca McDonald, Nicholas William Medendorp, JR., Gerald H. Negley, Katelyn P. Reighard
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Publication number: 20210128937Abstract: Methods and related devices for impinging light on tissue, for example within a body of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, stimulating enzymatic generation of nitric oxide to increase endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores of nitric oxide, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices and methods for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and targeted tissues with increased efficacy and reduced cytotoxicity.Type: ApplicationFiled: January 13, 2021Publication date: May 6, 2021Inventors: Nathan Stasko, David T. Emerson, Adam Cockrell, F. Neal Hunter, Michael John Bergmann, Rebecca McDonald, Nicholas William Medendorp, JR., Gerald H. Negley, Katelyn P. Reighard
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Publication number: 20210128936Abstract: Methods and related devices for impinging light on tissue, for example within a body of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, stimulating enzymatic generation of nitric oxide to increase endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores of nitric oxide, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices and methods for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and targeted tissues with increased efficacy and reduced cytotoxicity.Type: ApplicationFiled: January 13, 2021Publication date: May 6, 2021Inventors: Nathan Stasko, David T. Emerson, Adam Cockrell, F. Neal Hunter, Michael John Bergmann, Rebecca McDonald, Nicholas William Medendorp, JR., Gerald H. Negley, Katelyn P. Reighard
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Publication number: 20210128938Abstract: Methods and related devices for impinging light on tissue, for example within a body of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, stimulating enzymatic generation of nitric oxide to increase endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores of nitric oxide, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices and methods for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and targeted tissues with increased efficacy and reduced cytotoxicity.Type: ApplicationFiled: January 13, 2021Publication date: May 6, 2021Inventors: Nathan Stasko, David T. Emerson, Adam Cockrell, F. Neal Hunter, Michael John Bergmann, Rebecca McDonald, Nicholas William Medendorp, JR., Gerald H. Negley, Katelyn P. Reighard