Abstract: The invention relates to methods of adding identifier sequences to polynucleotides of an array. The identifier sequences comprise a plurality of nucleotide blocks. Also provided are arrays of polynucleotides having identifier sequences, microparticles comprising said arrays, a plurality of 5 said microparticles, surfaces comprising said arrays, kits and methods for generating libraries using the array, methods for determining the accuracy of sequencing or amplification an array, and methods of analysing said libraries.

Abstract: The invention relates to micro-particles in which polynucleotides are joined to a bead at the 3? end and include a linker that can be cleaved to separate the polynucleotides from the bead and provide free 3? hydroxyl groups. Also provided are arrays of polynucleotides, pluralities of micro-particles, fluidic compartments comprising micro-particles, methods of synthesising the arrays and methods of generating libraries using the array.

Abstract: A method of determining the pre-eclampsia status of a pregnant subject, comprising providing a biological sample obtained from the subject; and determining the presence or absence, and/or level, of one or more of Type XVII collagen alpha 1, leptin, neprilysin, Filamin B and Scavenger receptor class B member 1 in the biological sample, and preferably comparing the level determined with a control.