Patents by Inventor Adam D. Douglass
Adam D. Douglass has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10352945Abstract: The invention provides methods, cells and constructs for optical measurement of membrane potential. These methods can be used in cells that are not accessible to presently available methods using electrodes. The methods can be directed to, for example, high-throughput drug screening assays to determine agents that can affect membrane potential of a target cell.Type: GrantFiled: October 13, 2017Date of Patent: July 16, 2019Assignee: President and Fellows of Harvard CollegeInventors: Adam Ezra Cohen, Joel Kralj, Adam D. Douglass
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Patent number: 10161937Abstract: The invention provides methods for characterizing cellular physiology by incorporating into an electrically excitable cell an optical reporter of, and an optical actuator of, electrical activity. A signal is obtained from the optical reporter in response to a stimulation of the cell. Either or both of the optical reporter and actuator may be based on genetically-encoded rhodopsins incorporated into the cell. The invention provides all optical methods that may be used instead of, or as a complement to, traditional patch clamp technologies and that can provide rapid, accurate, and flexible assays of cellular physiology.Type: GrantFiled: July 10, 2017Date of Patent: December 25, 2018Assignee: President and Fellows of Harvard CollegeInventors: Adam Ezra Cohen, Joel Kralj, Adam D. Douglass, Daniel Hochbaum
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Publication number: 20180031553Abstract: The invention provides methods for characterizing cellular physiology by incorporating into an electrically excitable cell an optical reporter of, and an optical actuator of, electrical activity. A signal is obtained from the optical reporter in response to a stimulation of the cell. Either or both of the optical reporter and actuator may be based on genetically-encoded rhodopsins incorporated into the cell. The invention provides all optical methods that may be used instead of, or as a complement to, traditional patch clamp technologies and that can provide rapid, accurate, and flexible assays of cellular physiology.Type: ApplicationFiled: July 10, 2017Publication date: February 1, 2018Applicant: President and Fellows of Harvard CollegeInventors: Adam Ezra Cohen, Joel Kralj, Adam D. Douglass, Daniel Hochbaum
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Publication number: 20180031572Abstract: The invention provides methods, cells and constructs for optical measurement of membrane potential. These methods can be used in cells that are not accessible to presently available methods using electrodes. The methods can be directed to, for example, high-throughput drug screening assays to determine agents that can affect membrane potential of a target cell.Type: ApplicationFiled: October 13, 2017Publication date: February 1, 2018Applicant: President and Fellows of Harvard CollegeInventors: Adam Ezra Cohen, Joel Kralj, Adam D. Douglass
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Patent number: 9791455Abstract: The invention provides methods, cells and constructs for optical measurement of membrane potential. These methods can be used in cells that are not accessible to presently available methods using electrodes. The methods can be directed to, for example, high-throughput drug screening assays to determine agents that can affect membrane potential of a target cell.Type: GrantFiled: June 15, 2015Date of Patent: October 17, 2017Assignee: President and Fellows of Harvard CollegeInventors: Adam E. Cohen, Joel Kralj, Adam D. Douglass
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Patent number: 9702874Abstract: The invention provides methods for characterizing cellular physiology by incorporating into an electrically excitable cell an optical reporter of, and an optical actuator of, electrical activity. A signal is obtained from the optical reporter in response to a stimulation of the cell. Either or both of the optical reporter and actuator may be based on genetically-encoded rhodopsins incorporated into the cell. The invention provides all optical methods that may be used instead of, or as a complement to, traditional patch clamp technologies and that can provide rapid, accurate, and flexible assays of cellular physiology.Type: GrantFiled: November 16, 2015Date of Patent: July 11, 2017Assignee: President and Fellows of Harvard CollegeInventors: Adam E. Cohen, Joel Kralj, Adam D. Douglass, Daniel Hochbaum
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Publication number: 20160069876Abstract: The invention provides methods for characterizing cellular physiology by incorporating into an electrically excitable cell an optical reporter of, and an optical actuator of, electrical activity. A signal is obtained from the optical reporter in response to a stimulation of the cell. Either or both of the optical reporter and actuator may be based on genetically-encoded rhodopsins incorporated into the cell. The invention provides all optical methods that may be used instead of, or as a complement to, traditional patch clamp technologies and that can provide rapid, accurate, and flexible assays of cellular physiology.Type: ApplicationFiled: November 16, 2015Publication date: March 10, 2016Applicant: President and Fellows of Harvard CollegeInventors: Adam E. Cohen, Joel Kralj, Adam D. Douglass, Daniel Hochbaum
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Patent number: 9207237Abstract: The invention provides methods for characterizing cellular physiology by incorporating into an electrically excitable cell an optical reporter of, and an optical actuator of, electrical activity. A signal is obtained from the optical reporter in response to a stimulation of the cell. Either or both of the optical reporter and actuator may be based on genetically-encoded rhodopsins incorporated into the cell. The invention provides all optical methods that may be used instead of, or as a complement to, traditional patch clamp technologies and that can provide rapid, accurate, and flexible assays of cellular physiology.Type: GrantFiled: June 12, 2014Date of Patent: December 8, 2015Assignee: President and Fellows of Harvard CollegeInventors: Adam E. Cohen, Joel Kralj, Adam D. Douglass, Daniel Hochbaum
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Publication number: 20150285820Abstract: The invention provides methods, cells and constructs for optical measurement of membrane potential. These methods can be used in cells that are not accessible to presently available methods using electrodes. The methods can be directed to, for example, high-throughput drug screening assays to determine agents that can affect membrane potential of a target cell.Type: ApplicationFiled: June 15, 2015Publication date: October 8, 2015Applicant: President and Fellows of Harvard CollegeInventors: Adam E. Cohen, Joel Kralj, Adam D. Douglass
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Patent number: 9057734Abstract: The invention provides methods, cells and constructs for optical measurement of membrane potential. These methods can be used in cells that are not accessible to presently available methods using electrodes. The methods can be directed to, for example, high-throughput drug screening assays to determine agents that can affect membrane potential of a target cell.Type: GrantFiled: August 23, 2011Date of Patent: June 16, 2015Assignee: President and Fellows of Harvard CollegeInventors: Adam E. Cohen, Joel M. Kralj, Adam D. Douglass
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Publication number: 20140295413Abstract: The invention provides methods for characterizing cellular physiology by incorporating into an electrically excitable cell an optical reporter of, and an optical actuator of, electrical activity. A signal is obtained from the optical reporter in response to a stimulation of the cell. Either or both of the optical reporter and actuator may be based on genetically-encoded rhodopsins incorporated into the cell. The invention provides all optical methods that may be used instead of, or as a complement to, traditional patch clamp technologies and that can provide rapid, accurate, and flexible assays of cellular physiology.Type: ApplicationFiled: June 12, 2014Publication date: October 2, 2014Inventors: Adam E. Cohen, Joel Kralj, Adam D. Douglass, Daniel Hochbaum
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Publication number: 20130224756Abstract: The invention provides methods, cells and constructs for optical measurement of membrane potential. These methods can be used in cells that are not accessible to presently available methods using electrodes. The methods can be directed to, for example, high-throughput drug screening assays to determine agents that can affect membrane potential of a target cell.Type: ApplicationFiled: August 23, 2011Publication date: August 29, 2013Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Adam E. Cohen, Joel M. Kralj, Adam D. Douglass